Results 91 to 100 of about 46,386 (217)

Unravelling the initiator‐only stage in alginate grafting: Radical‐induced depolymerization and its impact on acrylamide grafting efficiency

The Canadian Journal of Chemical Engineering, Volume 104, Issue 8, Page 3996-4006, August 2026.
Abstract Free‐radical grafting of natural polymers often assumes that initiators only create active sites before monomer addition. We tested this by exposing sodium alginate to potassium persulphate (KPS) under typical grafting conditions without monomer (acrylamide).
Gustavo P. Zago, João B. P. Soares
wiley   +1 more source

Multifaceted Roles of Chloroquines in Gastrointestinal Disorders and Beyond

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Chloroquine (CQ) and hydroxychloroquine (HCQ) modulate lysosomal activity and autophagy, suppressing gastrointestinal inflammation and reshaping pathogenic microbiota. These mechanisms alleviate inflammatory bowel disease, inhibit associated tumor growth, and provide benefits in certain autoimmune and viral conditions.
Sihyun Jeong, Eunsoo Kim, Yong Sung Kim, Eunok Im   +3 more
wiley   +1 more source

Biomarker‐Based Prediction of OATP1B1 Activity in Clinical Routine—Investigating Coproporphyrins as Markers for Drug–Drug–Gene Interactions

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 492-500, August 2026.
Coproporphyrin I (CPI) is an established endogenous biomarker for detecting drug–drug interactions (DDIs) involving the hepatic uptake transporter Organic Anion Transporting Polypeptide 1B1 (OATP1B1, gene SLCO1B1). While CPI has been extensively studied in healthy volunteers using controlled pre‐ and post‐OATP1B1‐inhibitor sampling, its applicability ...
Leila Potzel, Anina Zumtaugwald, Anna Bollinger, Chiara Jeiziner, Kurt E. Hersberger, Florine Wiss, Markus L. Lampert, Samuel S. Allemann, Henriette E. Meyer zu Schwabedissen, Céline K. Stäuble   +9 more
wiley   +1 more source

Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 510-519, August 2026.
Genetic variation contributes substantially to interindividual and interpopulation differences in drug response, yet most pharmacogenomic studies remain biased toward European populations. Here, we systematically assessed pharmacogenomic variation across East Asians (EAS) and Europeans (EUR) using public genomic datasets and investigated the potential ...
Sihan Chen, Hongpu Chen, Shuhua Xu
wiley   +1 more source

Preserved Spermatogenesis and Hormonal Function in Men Receiving a Pretomanid Regimen (BPaMZ) for Pulmonary Drug‐Resistant Tuberculosis

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 501-509, August 2026.
Pretomanid is a component of the World Health Organization‐recommended treatment regimen for drug‐resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no corresponding effects were observed in nonhuman primates nor clinical hormone ...
Pauline Howell, Antonio Lombardi, William Brumskine, Lali Mikiashvili, Kim Boekelheide, Joanna Moreira, Alda Holsta, Matthew Betteridge, Lindsay Thompson, Angela Crook, Paul Bruinenberg, Maria Beumont, Eugene Sun, Francesca Conradie   +13 more
wiley   +1 more source

Fatal Isoniazid Poisoning [PDF]

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1995
Stewart, M F, Freemont, A J; id_orcid 0000-0002-9780-208X, Richardson, T   +2 more
openaire   +3 more sources

Design, Synthesis, and Biological Evaluation of Chiral Urea and Thiourea Derivatives as Multitarget‐Directed Anti‐Alzheimer Agents

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A series of novel chiral urea and thiourea compounds were designed as multitarget‐directed ligands for Alzheimer's disease and evaluated against hAChE, hBChE, and hMAO‐B, with exploratory assessment of HSD10. These chiral compounds were synthesized and fully characterized, and their enantiopurity was confirmed via HPLC.
Sule Erol Gunal, Senel Teke Tuncel, İlke Demir, İpek Baysal, Gökçen Telli, Safiye Sag Erdem, Gulberk Ucar, Michaela Hanzlova, Kamil Musilek, İlknur Dogan, Nesrin Gokhan Kelekci   +10 more
wiley   +1 more source

Integrated Phytochemical and Pharmacological Investigation of Mentha aquatica L.: Anti‐Inflammatory, Analgesic, and Safety Evidence From In Vivo Studies

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Mentha aquatica decocted extract contained mainly phenolic acids and showed a favorable oral safety profile in mice, with no significant subacute toxicity. Intraperitoneal administration caused dose‐dependent toxicity. The extract exhibited significant dose‐dependent anti‐inflammatory and analgesic activities in rodent models, supporting its potential ...
Meryem Tourabi, Khaoula Faiz, Rafik EL‐Mernissi, Bouchra Louasté, Mohammed Merzouki, Karima El‐Yagoubi, Layla Tahiri Elousrouti, Abdel‐Rhman Z. Gaafar, Mulugeta Tesemma, Esmael M. Alyami, Ohoud A. Alghamdi, Musa A. Said, Hina Ali, Badiaa Lyoussi, Elhoussine Derwich   +14 more
wiley   +1 more source

Consumed by Abdominal Distention

Arthritis Care &Research, Volume 78, Issue 8, Page 959-966, August 2026.
Abimbola Fadairo‐Azinge, James Grenert, Brian Haas, Mary Margaretten   +3 more
wiley   +1 more source

MetF‐Dependent Methionine Biosynthesis Is Required for Mycobacterium tuberculosis Survival and In Vivo Persistence

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
MetF is essential for both in vitro and in vivo growth of Mycobacterium tuberculosis, whereas MetE, previously considered essential in vitro, is dispensable in vivo. Given the importance of methionine and folate metabolism as drug targets, MetF represents a promising candidate, highlighting the need for in vivo validation.
Ikue Tosa, Tomoki Kitahara, Katsuki Takebe, Masaaki Nakayama, Yuko Ito, Akihito Nishiyama, Shintaro Seto, Hotaka Kawai, Hiharu Inoue, Yuki Fukada, Yuki Nishiya, Hitoshi Nagatsuka, Takayuki Wada, Manabu Ato, Sohkichi Matsumoto, Naoya Ohara   +15 more
wiley   +1 more source