Results 111 to 120 of about 64,783 (272)

Prurigo Pigmentosa – an increasingly diagnosed dermatological condition associated with ketogenic diet

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
SUMMARY Prurigo pigmentosa (PP) is a rare inflammatory dermatosis, clinically characterized by intensely pruritic, erythematous papules and papulovesicles, with reticular hyperpigmentation upon healing. We herein report four cases in adults of different ethnic backgrounds, in which the disease was associated with ketogenic metabolic states due to ...
Antigona Aliu, Milan Vidakovic, Marcel Krauß, Julia Hyun, Frank Oellig, Thilo Gambichler, Valentina Laura Müller, Alexander Kreuter   +7 more
wiley   +1 more source

Efficacy, safety, and pharmacokinetics of isoniazid affected by NAT2 polymorphisms in patients with tuberculosis: A systematic review

Clinical and Translational Science
N‐acetyltransferase 2 (NAT2) genetic polymorphisms might alter isoniazid metabolism leading to toxicity. We reviewed the impact of NAT2 genotype status on the pharmacokinetics, efficacy, and safety of isoniazid, a treatment for tuberculosis (TB).
Thanakorn Surarak, Supatat Chumnumwat, Wichit Nosoongnoen, Pramote Tragulpiankit   +3 more
doaj   +1 more source

Expert Consensus on the Diagnosis and Monitoring of Paroxysmal Nocturnal Hemoglobinuria (PNH): An Algorithmic Approach in an Era of New Treatments

European Journal of Haematology, EarlyView.
ABSTRACT Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder caused by a defect of glycosylphosphatidyl‐anchored proteins, leading to an uncontrolled complement‐mediated hemolysis. The advent of complement inhibitors in clinical practice radically changed patients' outcomes and survival.
Bruno Fattizzo, Monia Marchetti, Elisa Cannizzo, Arianna Gatti, Massimo Geuna, Anna Paola Iori, Maddalena Raia, Simona Sica, Francesco Buccisano   +8 more
wiley   +1 more source

Perioperative Management in Persons With Haemophilia on Rebalancing Therapies: A Narrative Review

Haemophilia, EarlyView.
ABSTRACT Introduction Perioperative management in haemophilia often requires on‐demand use of clotting factor concentrates (CFC) and/or bypassing agents. Rebalancing agents (fitusiran, concizumab, marstacimab) offer a novel approach to prophylaxis by modulating endogenous anticoagulant pathways to restore haemostatic balance.
Amanda M. Henderson, Roy Khalife, Kelsey Uminski   +2 more
wiley   +1 more source

Feasibility and clinical outcomes of routine point‐of‐care screening for opportunistic infections among people with advanced HIV disease in Guyana

HIV Medicine, EarlyView.
Abstract Objectives We evaluated the feasibility and outcomes of implementing comprehensive Point‐of‐care (POC) opportunistic infections (OIs) screening among people with Advanced HIV disease (AHD) in Guyana. Methods We conducted a prospective multicentre cohort study across seven sites between February 2024 and March 2025.
Antonio Camiro‐Zúñiga, Tariq Jagnarine, Divya Shivdas, Lakshmi Narain, Kwesi Vanccoten, Kampta Prashad, Abiola Jacobs, Quacy Grant, Mallika Mootoo, Narissa Lawerence, Suzanne Siebs, Escalada Rainier, Omar Sued, Freddy Perez   +13 more
wiley   +1 more source

Crystal and Molecular Structure and Stability of Isoniazid Cocrystals with Selected Carboxylic Acids

, 2016
Reaction of isoniazid with benzoic acid, sebacic acid, suberic acid, and cinnamic acid results in formation of cocrystals. Two polymorphs of isoniazid–suberic acid and two polymorphs of isoniazid–cinnamic acid cocrystals were isolated.
Sergey Belyakov (1984501), Inese Sarcevica (1984489), Liana Orola (1984498), Anton Podjava (1984492), Mikelis V Veidis (1984495)   +4 more
core   +1 more source

Single‐centre analysis of severe Coombs‐positive autoimmune haemolytic anaemia in an HIV‐endemic population

HIV Medicine, EarlyView.
Abstract Introduction Human immunodeficiency virus (HIV) is a rare cause of autoimmune haemolytic anaemia (AIHA) which requires prompt diagnosis and treatment. We compared clinical and laboratory findings in AIHA patients with and without HIV. Methods We included adults with severe AIHA (haemoglobin ≤8 g/dL) diagnosed at a tertiary academic centre ...
Kathleen O. De John, Karryn Brown, Jenna Bailey, Estelle R. Verburgh, Jessica J. Opie   +4 more
wiley   +1 more source

Isoniazid Allergy [PDF]

BMJ, 1957
openaire   +2 more sources

Withdrawing State? Spatiotemporal Geography of State Employment in Finland

Tijdschrift voor Economische en Sociale Geografie, EarlyView.
Abstract Using a novel dataset, we examine whether state jobs have centralised away from rural municipalities to larger cities in Finland, and how this process has affected regional disparities. Additionally, we test whether the centralisation of state jobs reflects state withdrawal or an adaptation to population decline.
Simo Rautiainen, Olli Lehtonen, Teemu Makkonen   +2 more
wiley   +1 more source

Patterns of Drug Resistance, Drug Resistance Conferring Mutations and Genomic DNA Methylation Revealed in Mycobacterium tuberculosis From South Africa

Tropical Medicine &International Health, EarlyView.
ABSTRACT Tuberculosis remains a major public health threat globally, with drug‐resistant strains undermining treatment efficacy. We analyzed 126 Mycobacterium tuberculosis (M. tuberculosis) isolates with diverse drug resistance spectra and selected 35 for whole genome sequencing (WGS) using Illumina NextSeq, SMRT PacBio Onso and SMRT PacBio Revio ...
Unarine Matodzi, Awelani Mutshembele, Eric Mensah, Dillon Muzondiwa, Ndivhuho A. Makhado, Oleg N. Reva   +5 more
wiley   +1 more source