Results 71 to 80 of about 2,755,321 (217)

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Case series: Kikuchi‐Fujimoto disease with diagnostic overlap

Rheumatology &Autoimmunity, EarlyView.
Kikuchi‐Fujimoto disease (KFD) is a rare, self‐limiting necrotizing lymphadenitis that poses significant diagnostic challenges due to its overlap with tuberculosis, systemic lupus erythematosus (SLE), and malignancy. We present four cases highlighting distinct diagnostic complexities: KFD mimicking tuberculosis with concomitant latent TB infection and ...
Ecem Kalemoglu, Ming Zheng, Danny Arias, Andreina M. Paulino, Aisha Niaz, James Devlin, Valentin Marian   +6 more
wiley   +1 more source

Infection risk in rheumatoid arthritis patients treated with biologic and targeted therapies

Rheumatology &Autoimmunity, EarlyView.
In this context, infections associated with each biologic and targeted drug are summarized to inform the stratification of RA patients, including the characteristics of the susceptible patients and their concomitant therapy. We aim to provide a benefit‐risk analysis for clinical decision, and vital indications for the prevention of highly correlated ...
Lujing Wang, Jieshi Lin, Jie Qian
wiley   +1 more source

Uptake of tuberculosis prevention therapy in people living with HIV/AIDS in northern Nigeria: a programme to increase use of isoniazid preventive therapy

The Lancet Global Health, 2020
Background: Tuberculosis is a main cause of death in people living with HIV and results in around 39 000 deaths every year in Nigeria. Isoniazid preventive therapy (IPT), the standard tuberculosis preventive therapy used in Nigeria, has been shown to ...
Fadimatu Yunusa, MPH, Maryam Bello, BSc, Gbenga A Kayode, PhD, Adeoye Adegboye, MPH, Geraldine Abone, MBBS, Fati Murtala-Ibrahim, B Pharm, Martha Okposo, MSc, Atinuke Anjorin, MBBS, Saswata Dutt, MBBS, Oche Yusuf, MHM, Nadia Sam-Agudu, Patrick Dakum, MPH   +11 more
doaj   +1 more source

The pooled estimates of isoniazid preventive therapy effect on confirmed Tuberculosis.

, 2015
* Random effect model**Prediction interval can only be estimated for more than two studiesCI: Confidence interval; IPT: Isoniazid preventive therapy; PI: Prediction interval; RR: Relative Risk; TST: Tuberculin Skin TestThe pooled estimates of isoniazid ...
Henok Tadesse Ayele (823954), Thomas P. A. Debray (401148), Marc J. M. Bonten (109524), Maaike S. M. van Mourik (112754)   +3 more
core   +1 more source

White light emitting molecular logic gates

Smart Molecules, EarlyView.
White light emitting smart molecules with Boolean logic computing ability are surveyed. Abstract White light emitting (WLE) materials are of considerable interest with commercial and societal applications in video displays and lighting devices. A characteristic property of WLE materials is the luminescence profile spanning from 380 to 700 nm.
Davide Benedetto Tiz, Massimo Catania, David C. Magri   +2 more
wiley   +1 more source

Real‐World Safety and Effectiveness of Icatibant in Patients With Hereditary Angioedema (HAE): Post‐Marketing Surveillance in Japan

The Journal of Dermatology, EarlyView.
ABSTRACT Hereditary angioedema (HAE) is a rare, autosomal dominant, life‐threatening disease characterized by recurrent attacks of swelling of the face, upper airway, gastrointestinal tract, limbs, and/or genitalia. Genetic mutations of the SERPING1 gene encoding the C1‐inhibitor (C1‐INH) plasma protein are associated with HAE‐C1INH.
Kumiko Hosono, Miyako Hoshino
wiley   +1 more source

WHO recommended collaborative TB/HIV activities: evaluation of implementation and performance in a rural district hospital in Cameroon

The Pan African Medical Journal, 2011
2% (n=77) respectively regarding HIV testing among TB patients and antiretroviral therapy coverage in TB/HIV co-infected patients. Provision of isoniazid preventive therapy (IPT) was inexistent in this hospital due mainly to the lack of tuberculin skin ...
Habakkuk Azinyui Yumo, Christopher Kuaban, Florian Neuhann   +2 more
doaj   +1 more source

Tuberculosis infection risk, preventive therapy care cascade and incidence of tuberculosis disease in healthcare workers at Maputo Central Hospital

BMC Infectious Diseases, 2019
Background Mozambican healthcare workers have high rates of latent and active tuberculosis, but occupational screening for tuberculosis is not routine in this setting.
Susannah K. Graves, Orvalho Augusto, Sofia Omar Viegas, Philip Lederer, Catarina David, Kristen Lee, Anila Hassane, Anilsa Cossa, Salma Amade, Susete Peleve, Pereira Zindoga, Leguesse Massawo, Francesca J. Torriani, Elizabete A. Nunes   +13 more
doaj   +1 more source

Isoniazid Preventive Therapy Added to ART to Prevent TB: An Individual Participant Data Meta-Analysis

, 2021
Background: Isoniazid preventive therapy prevents active tuberculosis in people with HIV, but previous studies have found no evidence of benefit in people with HIV who had a negative tuberculin skin test, and a non-significant effect on mortality.
Williams, BG, Eholie, S, Anglaret, X, Rangaka, M, Shapiro, A, Gabillard, D, Ford, N, Ross, JM, Wilkinson, RJ, Golub, J, Barnabas, R, Walker, A, Maartens, G, Boulle, A, Thomas, K, Badje, A   +15 more
core