Genetically Encoded Biosensors Reveal PKA Hyperphosphorylation on the Myofilaments in Rabbit Heart Failure [PDF]
, 2016 RATIONALE: In heart failure, myofilament proteins display abnormal phosphorylation, which contributes to contractile dysfunction. The mechanisms underlying the dysregulation of protein phosphorylation on myofilaments is not clear.
Barbagallo, Federica +15 more
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Case Reports in Endocrinology, 2018 Isoproterenol is known to cause insulin resistance and is often used to treat bradyarrhythmias from atrioventricular block. We report a case of isoproterenol induced diabetic ketoacidosis in a 77-year-old female patient treated with isoproterenol for ...
Ryan Hoff, Chung-Kay Koh
doaj +1 more source
Evaluation of the cytoprotective effects of thymoquinone on isoproterenol-induced rat aorta
Cukurova Medical Journal, 2022 Purpose: The aim of this study was to evaluate histologically and immunohistochemically the cytoprotective effects of thymoquinone (THQ) against isoproterenol (ISO)-induced aortic tissue damage.
Rifat Ozmen +2 more
doaj +1 more source
High-fat diet induces protein kinase A and G-protein receptor kinase phosphorylation of β2 -adrenergic receptor and impairs cardiac adrenergic reserve in animal hearts. [PDF]
, 2017 Key pointsPatients with diabetes show a blunted cardiac inotropic response to β-adrenergic stimulation despite normal cardiac contractile reserve. Acute insulin stimulation impairs β-adrenergically induced contractile function in isolated cardiomyocytes ...
Chiamvimonvat, Nipavan +8 more
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Jurnal Ilmu Kesehatan Indonesia, 2022 Background. Brain edema is swelling in the brain due to excessive accumulation of fluid in the brain. This condition is triggered by a decrease in cerebral blood flow (CBF) due to heart damage or isoproterenol administraion.
Muhammad Arief Ansyar +2 more
doaj +1 more source
Preventive effect of Agnucastoside C against Isoproterenol-induced myocardial injury
Scientific Reports, 2017 An iridoid glycoside, agnucastoside C (ACC) was isolated from the leaves of Moringa oliefera and its cardio protective potential was investigated in adult rats by examining the effects of this test compound, ACC at 30 mg/kg for 14 days in isoproterenol ...
S. Panda, A. Kar, S. Biswas
semanticscholar +1 more source
Journal of Medicine in Scientific Research, 2018 Aim and Background Congenital heart diseases constitute a major category of disorders associated with pulmonary hypertension in atrial septal defect there is tendency to repair essentially all large defect except some of those with severe obstructive ...
Amir S Michael
doaj +1 more source
ER/K linked GPCR-G protein fusions systematically modulate second messenger response in cells. [PDF]
, 2017 FRET and BRET approaches are well established for detecting ligand induced GPCR-G protein interactions in cells. Currently, FRET/BRET assays rely on co-expression of GPCR and G protein, and hence depend on the stoichiometry and expression levels of the ...
Dysthe, Matthew +4 more
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Ginsenoside Rg2 alleviates myocardial fibrosis by regulating TGF-β1/Smad signalling pathway
Pharmaceutical Biology, 2021 Context Panax ginseng C.A. Meyer (Araliaceae) has cardioprotective effects. Ginsenosides are responsible for most of the pharmacological activities of ginseng.
Quanwei Wang +5 more
doaj +1 more source
Metabolic and functional consequences of cytosolic 5′-nucleotidase-IA overexpression in neonatal rat cardiomyocytes [PDF]
, 2003 Adenosine exerts a spectrum of energy-preserving actions on the heart negative chronotropic effects. The pathways leading to adenosine formation have remained controversial.
Curto, Maria de Los Angeles +3 more
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