Molecules, 2020 Cardiac hypertrophy is an independent risk factor of many cardiovascular diseases. Several cardiovascular protective properties of Cymbopogon proximus have been reported. However, no reports investigating the direct effect of C. proximus essential oil on
Hassan N. Althurwi +4 more
doaj +1 more source
Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model
PLoS Genetics, 2016 We aimed to understand the genetic control of cardiac remodeling using an isoproterenol-induced heart failure model in mice, which allowed control of confounding factors in an experimental setting.
Jessica J Wang +8 more
semanticscholar +1 more source
Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of G(i)- and G(q)-mediated signaling [PDF]
, 1999 RGS proteins (Regulators of G protein Signaling) are a recently discovered family of proteins that accelerate the GTPase activity of heterotrimeric G protein α subunits of the i, q, and 12 classes.
Backlund, Peter S. +5 more
core +1 more source
Monitoring mitochondrial calcium and metabolism in the beating MCU-KO heart
Cell Reports, 2021 Summary: Optical methods for measuring intracellular ions including Ca2+ revolutionized our understanding of signal transduction. However, these methods are not extensively applied to intact organs due to issues including inner filter effects, motion ...
Anna Kosmach +8 more
doaj +1 more source
Ventricular Action Potential Adaptation to Regular Exercise: Role of β-adrenergic and K\u3csub\u3eATP\u3c/sub\u3e Channel Function [PDF]
, 2017 Regular exercise training is known to affect the action potential duration (APD) and improve heart function, but involvement of β-adrenergic receptor (β-AR) subtypes and/or the ATP-sensitive K+ (KATP) channel is unknown.
Fitts, Robert H., Wang, Xinrui
core +2 more sources
Intra-Operative Lidocaine Management in the Setting of Ventricular Tachycardia Storm: A Case Report. [PDF]
Clin Case RepABSTRACT Effective management of VT storm during catheter ablation involves discontinuation of antiarrhythmic agents to facilitate VT induction for mapping of the critical isthmus. Lidocaine is an ideal agent since arrhythmias remain inducible after its discontinuation.
Williams C +4 more
europepmc +2 more sources
Anti-adrenergic effects of endothelin on human atrial action potentials are potentially anti-arrhythmic [PDF]
, 2006 Endothelin-1 (ET-1) is elevated in patients with atrial fibrillation (AF) and heart failure. We investigated effects of ET-1 on human atrial cellular electrophysiological measurements expected to influence the genesis and maintenance of AF.
Kane, K.A. +3 more
core +1 more source
Reciprocal regulation of PKA and rac signaling [PDF]
, 2013 Activated G protein-coupled receptors (GPCRs) and receptor tyrosine kinases relay extracellular signals through spatial and temporal controlled kinase and GTPase entities.
A. Riml +47 more
core +1 more source
β2-adrenergic agonists modulate TNF-α induced astrocytic inflammatory gene expression and brain inflammatory cell populations [PDF]
, 2014 Background: The NF-kappa B signaling pathway orchestrates many of the intricate aspects of neuroinflammation. Astrocytic beta(2)-adrenergic receptors have emerged as potential regulators in central nervous system inflammation and are potential targets ...
Aerts, Joeri L +5 more
core +3 more sources
Alterations of medial prefrontal cortex bioelectrical activity in experimental model of isoprenaline-induced myocardial infarction [PDF]
, 2020 Background Clinical and animal studies have found that anxiety and depression are significantly more common after acute myocardial infarction (AMI).
Hrnčić, Dragan +7 more
core +1 more source