Results 111 to 120 of about 63,752 (305)

Unlocking the Potential of MXene‐Based Electrochemical Biosensors: A Review of Biofunctionalization Strategies and Biosensing Principles

Advanced Materials Technologies, EarlyView.
ABSTRACT Electrochemical biosensors enable the accurate and timely detection of clinical biomarkers, improving healthcare and precision medicine. MXene nanosheets, a class of 2D transition metal carbides, nitrides, and carbonitrides, are promising materials for developing next‐generation electrochemical biosensors due to their unique physicochemical ...
Muhsin Ali, Sharat Chandra Barman, Isobel Steer, Aya H. Alshareef, Dana Alsulaiman   +4 more
wiley   +1 more source

Isothermal amplification using a chemical heating device for point-of-care detection of HIV-1.

PLoS ONE, 2012
BackgroundTo date, the use of traditional nucleic acid amplification tests (NAAT) for detection of HIV-1 DNA or RNA has been restricted to laboratory settings due to time, equipment, and technical expertise requirements.
Kelly A Curtis, Donna L Rudolph, Irene Nejad, Jered Singleton, Andy Beddoe, Bernhard Weigl, Paul LaBarre, S Michele Owen   +7 more
doaj   +1 more source

Isothermal Amplification of Nucleic Acids

, 2021
Nucleic acid amplification technologies (NAATs) have become fundamental tools in molecular diagnostics, due to their ability to detect small amounts of target molecules. Since its development, Polymerase Chain Reaction (PCR) has been the most exploited method, being stablished as the “gold standard” technique for DNA amplification.
Oliveira, Beatriz B., Veigas, Bruno, Baptista, Pedro Viana   +2 more
openaire   +1 more source

Smartphone-based pathogen diagnosis in urinary sepsis patients. [PDF]

, 2018
BackgroundThere is an urgent need for rapid, sensitive, and affordable diagnostics for microbial infections at the point-of-care. Although a number of innovative systems have been reported that transform mobile phones into potential diagnostic tools, the
Barnes, Lucien, Choe, Jane, Fitzgibbons, Lynn N, Fox, Gary N, Fried, Jeffrey C, Heithoff, Douglas M, Mahan, Michael J, Mahan, Scott P, Marth, Jamey D, Soh, H Tom, Zambrano, Andrea   +10 more
core  

Galaxies in box: A simulated view of the interstellar medium

, 2012
We review progress in the development of physically realistic three dimensional simulated models of the galaxy.We consider the scales from star forming molecular clouds to the full spiral disc.
A. Rosen, A.D. Slyz, D. Ryu, D.S. Balsara, Frederick A. Gent, J.C. Raymond, K. Kuijken, K. Tomisaka, K.M. Ferrière, M. Hanasz, M.A. de Avillez, M.G. Wolfire, M.J. Korpi, M.K.R. Joung, M.M. Mac Low, O. Gressel, R.A. Piontek   +16 more
core   +1 more source

Nanomolecular detection of human influenza virus type A using reverse transcription loop-mediated isothermal amplification assisted with rod-shaped gold nanoparticles [PDF]

, 2014
Reverse transcription loop-mediated isothermal amplification (RT-LAMP) and rod-shaped gold nanoparticles (gold nanorods; GNRs) were employed for nanomolecular detection of human influenza virus type A RNA.
Gill, P., Niazi, A., Nikbakht, H., Tabarraei, A.   +3 more
core   +1 more source

Advances in Electroactive Liquid Crystal Elastomers for Intelligent Robotics and Electronics

Advanced Robotics Research, EarlyView.
Electroactive liquid crystal elastomers (eLCEs) integrate molecular anisotropy with electrical functionality to enable programmable actuation and reconfigurable electronics. This review classifies eLCEs into robotic actuators and adaptive electronics, summarizes key actuation mechanisms, and highlights fabrication strategies that bridge materials to ...
Kavita Ramesh Rathod, Sena Chon, Jae Hyuk Hwang, Sung Hyuk Park, Woohwa Lee, Joonmyung Choi, Shi Hyeong Kim, Seung Hwan Ko, Changsoon Choi, Seon Jeong Kim, Dong‐Gyun Kim, Habeom Lee, Kyung Gook Cho, Woon‐Hong Yeo, Hyun Kim   +14 more
wiley   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Gravitational Lenses

, 1999
The purpose of these lecture notes is to describe the gravitational lens effects in different astrophysical contexts. These notes are voluntarily focused on the fundamental mechanisms and the basic concepts that are useful to describe these effects.
Bernardeau, F.
core   +2 more sources