Results 121 to 130 of about 63,752 (305)

An Artificial Antibody‐Based Toolbox Accelerates Validation of Hidden Microproteins Encoded by the Dark Genome

Advanced Science, EarlyView.
Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He, Anqi Zhang, Zhanchen Guo, Qi Li, Song Gao, Wenyan Guan, Ying Li, Jingran Chen, Sijia Sun, Jian He, Zhen Liu   +10 more
wiley   +1 more source

Strand displacement amplification—an isothermal,in vitroDNA amplification technique

Nucleic Acids Research, 1992
Strand Displacement Amplification (SDA) is an isothermal, in vitro nucleic acid amplification technique based upon the ability of HincII to nick the unmodified strand of a hemiphosphorothioate form of its recognition site, and the ability of exonuclease deficient klenow (exo- klenow) to extend the 3'-end at the nick and displace the downstream DNA ...
G T, Walker, M S, Fraiser, J L, Schram, M C, Little, J G, Nadeau, D P, Malinowski   +5 more
openaire   +3 more sources

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

One-step loop-mediated isothermal amplification system for Mycobacterium marinum detection

Microbiology Spectrum
Mycobacterium marinum is the etiological agent of cutaneous nontuberculous mycobacteriosis, inducing granuloma formation in human skin. Other mycobacterial species, including Mycobacterium ulcerans, Mycobacterium chelonae, and Mycobacterium fortuitum ...
Kayo Okumura, Yuji Miyamoto, Satoshi Mitarai, Manabu Ato   +3 more
doaj   +1 more source

Solid phase isothermal amplification

, 2019
The present invention relates to an amplification technology for multiple, rapid, sensitive, specific detection of nucleic acids in samples originating from the environment, water, food, animals, plants, microorganisms, cell cultures, or humans. In particular, the present invention relates to isothermal amplification and detection of nucleic acids ...
Wolff, Anders, Bang, Dang, Quyen, Than, Golabi, Mohsen, Dave, Vivek   +4 more
openaire   +1 more source

Rotation of Crystal Seed During Early Stages of Growth Reveals the Anisotropy of Glass Matrix

Advanced Science, EarlyView.
Molecular dynamics simulations reveal that crystal seeds can spontaneously rotate within glass at high temperatures due to anisotropic forces at the glass‐crystal interface. This rotation challenges the long‐held view of glass as an isotropic solid and highlights how atomic‐scale inhomogeneities can influence crystal growth and microstructure of LiNbO3‐
R. Thapa, E. J. Musterman, H. Jain, V. Dierolf, M. E. McKenzie   +4 more
wiley   +1 more source

Isothermal Multiple Displacement Amplification [PDF]

The Journal of Molecular Diagnostics, 2004
Rajyalakshmi Luthra, L. Jeffrey Medeiros
openaire   +1 more source

The stability of late-type stars close to the Eddington limit [PDF]

, 1997
Super-Eddington luminosities in hydrostatic model atmospheres manifest themselves by the presence of gas pressure inversions. Such inversions are not an artifact of the assumption of hydrostatic equilibrium but can also be present in hydrodynamical model
Asplund, Martin
core   +3 more sources

Dynamics of the Disks of Nearby Galaxies

, 2008
I describe how the dynamics of galactic disks can be inferred by imaging and spectroscopy. Next I demonstrate that the decomposition of the rotation curves of spiral galaxies into the contributions by the various components of the galaxies is highly ...
Arifyanto, Athanassoula, Bell, Bottema, de Blok, de Blok, Freeman, Fuchs, Fuchs, Fuchs, Gerssen, Gerssen, Hockney, Lee, Lindblad, Navarro, Prugniel, Rubin, Toomre, van Albada, Verheijen, Weidner   +21 more
core   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source