Results 21 to 30 of about 648 (166)

Pharmacological targeting of the NLRP3 LRR domain with isothiazolinones overcomes CRID3-resistant inflammation [PDF]

EMBO Molecular Medicine
The NLRP3 inflammasome is a key driver in inflammatory, infectious, metabolic, and neurodegenerative diseases. Although the NLRP3 inhibitor CRID3 (also known as MCC950) exhibits potent activity, it cannot inhibit several hyperactive NLRP3 mutations ...
Hawon Woo, Yeonseo Jang, Soyeon Kim, Wonyoung Kim, Fenfen Zhang, Raghvendra Mall, Chirag N Patel, Melan Kurera, Chinh Ngo, Simon H Jiang, Asia Nicotra, Bénédicte F Py, Min Zheng, Si Ming Man, Rajendra Karki   +14 more
doaj   +2 more sources

Cosmetic Interventions for Skin Microbiome Modulation: Current Strategies and Future Directions. [PDF]

Skin Res Technol
ABSTRACT Background Human skin harbors a highly diverse and dynamic microbiome that maintains barrier function and homeostasis, while endogenous/exogenous factors and cosmetic products modulate microbial balance. Dysbiosis contributes to inflammatory diseases like atopic dermatitis and acne; however, evidence for microbiome‐targeted cosmetics remains ...
Taléns-Visconti R, Diez-Sales O, Nácher A.   +2 more
europepmc   +2 more sources

Isothiazolinone derivatives and allergic contact dermatitis: a review and update

Journal of the European Academy of Dermatology and Venereology, 2019
Allergic contact dermatitis (ACD) from isothiazolinones has frequently been described in the literature. Following an epidemic of sensitization to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) in the 1980s, and more recently to MI, the ...
de Montjoye, L., Herman, Anne, Baeck, Marie, A. Herman, M. Baeck, Tromme, I., Aerts, Olivier, O. Aerts, L. de Montjoye, de Montjoye, Laurence, Baeck, M., Aerts, O., Goossens, An, Goossens, A., Herman, A., A. Goossens, Tromme, Isabelle, Goossens, Annie, I. Tromme   +18 more
core   +4 more sources

Isothiazolinones: from their domestic uses to their release into the environment

, 2022
International audienceIsothiazolinones are ubiquitous in our daily life; they are used as preservatives in cosmetics, household products and in building materials.
Bressy, A, Martinache, Pierre, Moilleron, Régis, Tedoldi, Damien, Paijens, Claudia, Bonnaud, Bertille   +5 more
core   +8 more sources

Isothiazolinones

, 2018
Jakob Ferløv Schwensen, Jeanne Duus Johansen   +1 more
core   +2 more sources

Isothiazolinone dysregulates the pattern of miRNA secretion: Endocrine implications for neurogenesis

Environment International, 2023
Isothiazolinones are extensively used as preservatives and disinfectants in personal care products and household items. The unintended exposure of humans and animals to isothiazolinones has led to increasing concerns about their health hazards.
Lizhu Tang, Jing Li, Chenyan Hu, Bingsheng Zhou, Paul K.S. Lam, Lianguo Chen   +5 more
doaj   +1 more source

Development of image analysis tool to evaluate Langerhans cell migration after exposure to isothiazolinones. [PDF]

Arch Toxicol
Incidence of allergic contact dermatitis (ACD) is rising worldwide as a consequence of raising chemical exposure, especially from biocides present in common water-based products such as cosmetics and household products.
Oltramare C, Burri O, Hopf NB, Jaccoud S, Seitz A, Applegate LA, Hirt-Burri N, Berthet A.   +7 more
europepmc   +2 more sources

Simultaneous Determination of Isothiazolinones and Parabens in Cosmetic Products Using Solid-Phase Extraction and Ultra-High Performance Liquid Chromatography/Diode Array Detector

Pharmaceuticals, 2020
Isothiazolinones methylisothiazolinone (MI) and methylchloroisothiazolinone (MCI), and parabens methylparaben (MP), ethylparaben (EP), propylparaben (PP) and butylparaben (BP) are the most common synthetic preservatives.
Hazim Mohammed Ali, Ibrahim Hotan Alsohaimi, Mohammad Rizwan Khan, Mohammad Azam   +3 more
doaj   +1 more source

Efficiency of Cu, Ag, and Fe Nanoparticles As Detergents Preservatives Against E. coli and S. aureus [PDF]

Nanochemistry Research, 2020
In this study, Cu, Ag, and Fe nanoparticles (NPs) are used in shampoo, hand washing liquid (HWL) and dish washing liquid (DWL) instead of the conventional synthetic preservatives such as isothiazolinones; since the latter often act as potent sensitizers ...
Marzieh Miranzadeh, Mohammad Kassaee, Fahimeh Afshari   +2 more
doaj   +1 more source

Sensitization to isothiazolinones in the Spanish Contact Dermatitis Registry (REIDAC). 2019-2021 epidemiological situation [PDF]

, 2022
Background: current frequency and risk factors for sensitization to methylisothiazolinone (MI), methylchloroisothiazolinone/methylisothiazolinone (MCI/MI), benzisothiazolinone (BIT) and octylisothiazolinone (OIT) in Spain are not well known.
Hernández Fernández, Carlos Pelayo, García-Doval, Ignacio, Giménez Arnau, Anna Maria   +2 more
core   +2 more sources