Results 11 to 20 of about 254,991 (338)

Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse model [PDF]

, 2012
Ovarian cancer is the leading cause of cancer related deaths in women. Genetic alterations including overexpression of EGFR play a crucial role in ovarian carcinogenesis.
Joseph Alan Bauer, Parul Gupta, Prabodh K. Kandala, Sanjay K. Srivastava, Sivakumar Loganathan   +4 more
core   +13 more sources

Optimization of Germination Process of Isothiocyanate Enrichment in Broccoli Sprouts by Response Surface Methodology

Shipin gongye ke-ji, 2022
The accumulation of isothiocyanate in germinated broccoli under ZnSO4-melatonin treatment was optimized. The isothiocyanate content, bud length and fresh weight of broccoli during germination were used as indices to study the effects of germination ...
Minglang GU, Yingqi GUO, Yongqi YIN, Xudong HE   +3 more
doaj   +1 more source

Anti‐pruritic effect of isothiocyanates: Potential involvement of toll‐like receptor 3 signaling

Pharmacology Research & Perspectives, 2022
The innate immune system has an emerging role as a mediator of neuro‐immune communication and a therapeutic target for itch. Toll‐like receptor 3 (TLR3) plays an important role in itch, as shown in TLR3 knock‐out mice.
Masaki Moriyama, Mitsuhiro Konno, Kanako Serizawa, Natsumi Yuzawa, Yuki Majima, Ikuo Hayashi, Tomohiko Suzuki, Mie Kainoh   +7 more
doaj   +1 more source

Apoptotic Potential of Glucomoringin Isothiocyanate (GMG-ITC) Isolated from Moringa oleifera Lam Seeds on Human Prostate Cancer Cells (PC-3)

Molecules, 2023
Inhibition of several protein pathways involved in cancer cell regulation is a necessary key in the discovery of cancer chemotherapy. Moringa oleifera Lam is often used in traditional medicine for the treatment of various illnesses.
Nurul Ashikin Abd Karim, Aziza Hussein Bakheit Adam, Mohammed Sani Jaafaru, Yaya Rukayadi, Ahmad Faizal Abdull Razis   +4 more
doaj   +1 more source

Synthetic and mechanistic study on the conjugate isothiocyanation of enones with trimethylsilyl isothiocyanate

Organic & Biomolecular Chemistry, 2023
The conjugate isothiocyanation of enones with trimethylsilyl isothioyanate provides excellent yields of β-isocyanato ketones under mild conditions, through a thermodynamically-controlled addition of the thiocyanate anion on the protonated enone.
Diana Marlén Castaneda Bagatella, Pier Alexandre Champagne   +1 more
openalex   +3 more sources

Enantiopure (S)-butan-2-yl N-(4-x-phenyl)thiocarbamates, x = NO2, OCH3, F, and Cl

Acta Crystallographica Section E: Crystallographic Communications, 2023
The structures of (S)-butan-2-yl N-(4-nitrophenyl)thiocarbamate, C11H14N2O3S, (I), (S)-butan-2-yl N-(4-methoxyphenyl)thiocarbamate, C12H17NO2S, (II), (S)-butan-2-yl N-(4-fluorophenyl)thiocarbamate, C11H14FNOS, (III), and (S)-butan-2-yl N-(4-chlorophenyl ...
Werner Kaminsky, Max Kaganyuk
doaj   +1 more source

Isothiocyanate From Moringa oleifera Seeds Inhibits the Growth and Migration of Renal Cancer Cells by Regulating the PTP1B-dependent Src/Ras/Raf/ERK Signaling Pathway

Frontiers in Cell and Developmental Biology, 2022
Moringa oleifera Lam. is a tropical and subtropical plant that has been used for centuries as both food and traditional medicine. 4-[(α-L-Rhamnosyloxy) benzyl] isothiocyanate (MIC-1) is an active substance in M.
Jing Xie, Jing Xie, Jing Xie, Ying-Yan Qian, Yang Yang, Lin-Jie Peng, Jia-Ying Mao, Ming-Rong Yang, Yang Tian, Yang Tian, Yang Tian, Jun Sheng   +11 more
doaj   +1 more source

Antibacterial Activity of Glucomoringin Bioactivated with Myrosinase against Two Important Pathogens Affecting the Health of Long-Term Patients in Hospitals

Molecules, 2013
Glucosinolates (GLs) are natural compounds present in species of the order Brassicales and precursors of bioactive isothiocyanates (ITCs). In the recent years, they have been studied mainly for their chemopreventive as well as novel chemotherapeutics ...
Maria Galuppo, Gina Rosalinda De Nicola, Renato Iori, Pia Dell'Utri, Placido Bramanti, Emanuela Mazzon   +5 more
doaj   +1 more source

Sulforaphane reduces obesity by reversing leptin resistance

eLife, 2022
The ascending prevalence of obesity in recent decades is commonly associated with soaring morbidity and mortality rates, resulting in increased health-care costs and decreased quality of life.
Işın Çakır, Pauline Lining Pan, Colleen K Hadley, Abdulrahman El-Gamal, Amina Fadel, Dina Elsayegh, Omnia Mohamed, Nasser M Rizk, Masoud Ghamari-Langroudi   +8 more
doaj   +1 more source

Comparative Analysis of Volatile Flavor Compounds in Seven Mustard Pastes via HS-SPME–GC–MS

Molecules, 2023
To identify the volatile flavor components in mustard paste (MP), the volatile compounds in seven MPs available on the market were isolated and analyzed by headspace solid-phase microextraction combined with gas chromatography–mass spectrometry.
Miao Liang, Rui Wang, Yajian Wu, Runhu Xin, Wei Guan, Yuping Liu   +5 more
doaj   +1 more source