Results 211 to 220 of about 172,529 (267)
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Chemoprevention by isothiocyanates
Journal of Cellular Biochemistry, 1995Naturally occurring and synthetic isothiocyanates are among the most effective chemopreventive agents known. A wide variety of isothiocyanates prevents cancer in the rat lung, mammary gland, esophagus, liver, small intestine, colon, and bladder. Mechanistic studies have shown that this chemopreventive activity is due to favorable modification of phase ...
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The reaction of fluorescein isothiocyanate with thiols: A method for assay of isothiocyanates
Analytical Biochemistry, 1983The reversible formation of dithiourethanes from fluorescein isothiocyanate and mercaptoethanol or mercaptoethylamine has been studied. It is shown that it is possible to use the reaction as the basis for a spectrophotometric titration of a number of isothiocyanates with mercaptoethanol.
A F, Wilderspin, N M, Green
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Synthesis of Isothiocyanates: An Update
Synthesis, 2019Isothiocyanates (ICTs) are a group of molecules that can be used for many different purposes, they exhibit anticancer, antimicrobial, antibiotic, and anti-inflammatory properties. The synthesis of isothiocyanates has been a focus of many researchers for nearly the past 100 years.
Kayla Eschliman, Stefan Bossmann
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Isothiocyanates and Xenobiotic Detoxification
Molecular Nutrition & Food Research, 2018AbstractThe potential of isothiocyanates to antagonize the carcinogenicity of structurally diverse chemicals has been established in animals. A feasible mechanism of action involves protecting DNA by reducing the availability of the genotoxic metabolites of chemical carcinogens by either inhibiting their generation and/or stimulating their ...
Abdull Razis, Ahmad Faizal +2 more
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Organic & Biomolecular Chemistry, 2023
The conjugate isothiocyanation of enones with trimethylsilyl isothioyanate provides excellent yields of β-isocyanato ketones under mild conditions, through a thermodynamically-controlled addition of the thiocyanate anion on the protonated enone.
Yanmei Li +5 more
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The conjugate isothiocyanation of enones with trimethylsilyl isothioyanate provides excellent yields of β-isocyanato ketones under mild conditions, through a thermodynamically-controlled addition of the thiocyanate anion on the protonated enone.
Yanmei Li +5 more
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Chemopreventive Functions of Isothiocyanates
Drug News & Perspectives, 2005Numerous animal and epidemiological studies have demonstrated that consumption of cruciferous vegetables is inversely correlated with the cancer incidence. Strong anticarcinogenic activities of cruciferous vegetables are attributed to the high abundance of glucosinolates.
Young-Sam, Keum +2 more
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Isothiocyanates in Cancer Prevention
Drug Metabolism Reviews, 2004Isothiocyanates are sulfur-containing compounds which are largely responsible for the typical flavor of cruciferous vegetables. In animals and humans they are conjugated with glutathione; the first product of this reaction is a dithiocarbamate, which can be ultimately metabolized to the corresponding mercapturic acid, excreted in urine.
Franca, Bianchini, Harri, Vainio
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Pharmacokinetics and pharmacodynamics of isothiocyanates
Drug Metabolism Reviews, 2011Isothiocyanates from Brassica vegetables are of great interest for use in the cure of bacterial infections, as is their potential application in the prevention and treatment of cancer. Although much information is available on their mode of action within the cell, when it comes to the question of whether the necessary pharmacologic concentration has ...
Lamy, Evelyn +3 more
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The clastogenic effects of isothiocyanates
Mutation Research/Genetic Toxicology, 1993Four isothiocyanates (ITCs), three of which are commonly found in the human diet, were tested for the ability to induce chromosome aberrations in an SV40-transformed Indian muntjac cell line. Whilst allyl ITC was found to be inactive the other three (benzyl ITC, phenethyl ITC and phenyl ITC) were found to be significant inducers of chromosome damage in
S R, Musk, I T, Johnson
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Biological targets of isothiocyanates
Biochimica et Biophysica Acta (BBA) - General Subjects, 2011Isothiocyanates are phytochemicals with a broad array of effects in biological systems. Bioactivity includes the stimulation of cellular antioxidant systems, induction of apoptosis and interference with cytokine production and activity. Epidemiological evidence and experimental studies indicate that naturally occurring isothiocyanates and synthetic ...
Kristin K, Brown, Mark B, Hampton
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