Results 221 to 230 of about 183,701 (312)

Octreotide Counteracts IFN-γ-Induced Endothelial Inflammation. [PDF]

open access: yesJ Biochem Mol Toxicol
Fakir S   +3 more
europepmc   +1 more source

LncRNA NORAD Enhances Inflammatory Injury in Sepsis‐Associated Acute Lung Damage Through miR‐150‐5p/STAT1‐Dependent NF‐κB Activation

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Acute lung injury (ALI) is a severe complication of sepsis, yet the role of lncRNA NORAD in its pathogenesis remains unclear. Using LPS‐stimulated BEAS‐2B and HBEC3‐KT cells as well as cecal ligation and puncture (CLP)‐induced ALI models in C57BL/6 mice, we found that NORAD expression was markedly upregulated and promoted cell injury ...
Han Liu   +4 more
wiley   +1 more source

On the Assembly of Actin Polymerization‐Powered Motors

open access: yesMacromolecular Rapid Communications, EarlyView.
Actin polymerization‐powered motors have the highest speed when the actin recruiting‐polymerizing proteins are immobilized in polymer brushes on their surface. These motors orbit around larger tracer particles at pH above the isoelectric point of ActA but dock onto the tracer particles’ surface at lower pH. ABSTRACT Nano‐ and micromotors are a class of
Miguel A. Ramos Docampo   +2 more
wiley   +1 more source

Coumarin-Thiourea Hybrids: Structural Features Governing CA Inhibition and Antiproliferative Effects. [PDF]

open access: yesInt J Mol Sci
Fuentes-Aguilar A   +12 more
europepmc   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

open access: yesPortal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao   +4 more
wiley   +1 more source

Interplay of Ser273 Phosphorylation and K268 and K293 Acetylation in PPARγ: Implications for PPARγ Activation

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) play a critical role in regulating the transcriptional activity of PPARγ, a nuclear receptor central to glucose and lipid homeostasis. Among these, lysine acetylation at K268 and K293 and phosphorylation at S273 are particularly relevant to insulin sensitivity.
Caique Camargo Malospirito   +6 more
wiley   +1 more source

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