Results 301 to 310 of about 254,991 (338)

Chemoprevention by isothiocyanates

Journal of Cellular Biochemistry, 1995
Naturally occurring and synthetic isothiocyanates are among the most effective chemopreventive agents known. A wide variety of isothiocyanates prevents cancer in the rat lung, mammary gland, esophagus, liver, small intestine, colon, and bladder. Mechanistic studies have shown that this chemopreventive activity is due to favorable modification of phase ...
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The reaction of fluorescein isothiocyanate with thiols: A method for assay of isothiocyanates

Analytical Biochemistry, 1983
The reversible formation of dithiourethanes from fluorescein isothiocyanate and mercaptoethanol or mercaptoethylamine has been studied. It is shown that it is possible to use the reaction as the basis for a spectrophotometric titration of a number of isothiocyanates with mercaptoethanol.
A F, Wilderspin, N M, Green
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Chemopreventive Functions of Isothiocyanates

Drug News & Perspectives, 2005
Numerous animal and epidemiological studies have demonstrated that consumption of cruciferous vegetables is inversely correlated with the cancer incidence. Strong anticarcinogenic activities of cruciferous vegetables are attributed to the high abundance of glucosinolates.
Young-Sam, Keum, Woo-Sik, Jeong, Ah-Ng Tony, Kong   +2 more
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The clastogenic effects of isothiocyanates

Mutation Research/Genetic Toxicology, 1993
Four isothiocyanates (ITCs), three of which are commonly found in the human diet, were tested for the ability to induce chromosome aberrations in an SV40-transformed Indian muntjac cell line. Whilst allyl ITC was found to be inactive the other three (benzyl ITC, phenethyl ITC and phenyl ITC) were found to be significant inducers of chromosome damage in
S R, Musk, I T, Johnson
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Isothiocyanates and Xenobiotic Detoxification

Molecular Nutrition & Food Research, 2018
AbstractThe potential of isothiocyanates to antagonize the carcinogenicity of structurally diverse chemicals has been established in animals. A feasible mechanism of action involves protecting DNA by reducing the availability of the genotoxic metabolites of chemical carcinogens by either inhibiting their generation and/or stimulating their ...
Ahmad Faizal, Abdull Razis, Nattaya, Konsue, Costas, Ioannides   +2 more
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Synthesis of Isothiocyanates: An Update

Synthesis, 2019
Isothiocyanates (ICTs) are a group of molecules that can be used for many different purposes, they exhibit anticancer, antimicrobial, antibiotic, and anti-inflammatory properties. The synthesis of isothiocyanates has been a focus of many researchers for nearly the past 100 years.
Kayla Eschliman, Stefan Bossmann
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Isothiocyanates in Cancer Prevention

Drug Metabolism Reviews, 2004
Isothiocyanates are sulfur-containing compounds which are largely responsible for the typical flavor of cruciferous vegetables. In animals and humans they are conjugated with glutathione; the first product of this reaction is a dithiocarbamate, which can be ultimately metabolized to the corresponding mercapturic acid, excreted in urine.
Franca, Bianchini, Harri, Vainio
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Biological targets of isothiocyanates

Biochimica et Biophysica Acta (BBA) - General Subjects, 2011
Isothiocyanates are phytochemicals with a broad array of effects in biological systems. Bioactivity includes the stimulation of cellular antioxidant systems, induction of apoptosis and interference with cytokine production and activity. Epidemiological evidence and experimental studies indicate that naturally occurring isothiocyanates and synthetic ...
Kristin K, Brown, Mark B, Hampton
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Tetraalkylammonium Uranyl Isothiocyanates

Inorganic Chemistry, 2012
Three tetraalkylammonium uranyl isothiocyanates, [(CH(3))(4)N](3)UO(2)(NCS)(5) (1), [(C(2)H(5))(4)N](3)UO(2)(NCS)(5) (2), and [(C(3)H(7))(4)N](3)UO(2)(NCS)(5) (3), have been synthesized from aqueous solution and their structures determined by single-crystal X-ray diffraction. All of the compounds consist of the uranyl cation equatorially coordinated to
Clare E, Rowland, Mercouri G, Kanatzidis, L, Soderholm   +2 more
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Structure of isothiocyanate methemoglobin

Journal of Molecular Biology, 1981
Abstract The structure of the complex of the ambidentate ligand thiocyanate with horse methemoglobin was compared with that of acid methemoglobin and azide methemoglobin by X-ray difference Fourier techniques. Thiocyanate is co-ordinated to iron exclusively by its nitrogen atom, and thus forms the isothiocyanate complex.
Z R, Korszun, K, Moffat
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