Results 231 to 240 of about 92,950 (293)

Comparative cranial biomechanics reveal macroevolutionary trends in theropod dinosaurs, with emphasis on Tyrannosauroidea

The Anatomical Record, EarlyView.
Abstract Tyrannosaurus is viewed as a model organism in vertebrate paleontology, with numerous studies analyzing its feeding biomechanics. Nonetheless, the evolution of this feeding performance has been under‐addressed in Tyrannosauroidea, especially in basal tyrannosauroids. Here we used muscle‐force reconstruction and finite element analysis (FEA) to
Evan Johnson‐Ransom, Paul Gignac, Daniel E. Barta, Ryan N. Felice, Eric Snively   +4 more
wiley   +1 more source

Elevated Temperature Effects on Protein Turnover Dynamics in Arabidopsis thaliana Seedlings Revealed by ¹⁵N-Stable Isotope Labeling and ProteinTurnover Algorithm. [PDF]

Int J Mol Sci
Fan KT, Xu Y, Hegeman AD.
europepmc   +1 more source

Gleaning the Rocky Shore? 2500 Years of Coastal Resource Use at Red Bluff 1, GunaiKurnai Country, SE Australia

Archaeology in Oceania, EarlyView.
ABSTRACT Shell middens in Gippsland along the eastern half of Victoria's coastline have usually been characterised as small, short‐duration camp sites with relatively low shell densities and low taxonomic diversity. Here we present new excavation results from a dense, high‐diversity site at Red Bluff near the eastern end of GunaiKurnai Country, a ...
Patrick Faulkner, Bruno David, David M. Kennedy, Fiona Petchey, Joanna Fresløv, Ashleigh J. Rogers, Jillian Garvey, Rachel Kirby, Runjie Yuan, Russell Mullett, John Stanisic, Kyne Krusic‐Golub, V. Ruth Pullin, Matthew C. McDowell, Robert J. Skelly, Anthony Romano, Vanessa N. L. Wong, GunaiKurnai Land and Waters Aboriginal Corporation   +17 more
wiley   +1 more source

The E3 Ubiquitin Ligase UBE3B Regulates Synaptic Development and Cortical Network Activity

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication, abnormal social interactions, and restricted, repetitive behaviors. Pathogenic mutations in UBE3B result in neurodevelopmental disease, including intellectual disability, lack of speech, and ASD.
Shayal Vashisth, Aleya Shedd, Ariel Aiken, Solmi Cheon, Josh Bandopadhay, Kiran Kaur, Kimberly M. Huber, Maria H. Chahrour   +7 more
wiley   +1 more source

Stable isotope labeling kinetics of neurofilament lightin vitroandin vivo

Leckey CA, Giovannucci TA, Coulton JB, He Y, Sato C, Ghoshal N, Vignarajah T, Jaunmuktane Z, Barthélemy NR, Zetterberg H, Elbert DL, Mills K, Wray S, Bateman RJ, Paterson RW.   +14 more
europepmc   +1 more source

Effects of Renal and Hepatic Impairment on the Pharmacokinetics of Zilurgisertib

British Journal of Clinical Pharmacology, EarlyView.
Aim Small‐molecule activin receptor‐like kinase‐2 inhibitor zilurgisertib (INCB000928) is under investigation in a pivotal trial for the treatment of fibrodysplasia ossificans progressiva (FOP), an ultrarare genetic condition. This analysis assessed effects of renal and hepatic impairment on zilurgisertib pharmacokinetics.
Yan‐ou Yang, Yunlan Fang, Phillip Wang, Xiang Liu, Jay Getsy, Kevin Rockich   +5 more
wiley   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Effect of carbamazepine on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader, in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang, Jennifer A. Winton, Kyle T. Matschke, Alexandre Stouffs, Kimberly C. Lee, Yuanyuan Zhang, Wenlian Qiao, Weiwei Tan   +7 more
wiley   +1 more source

Correction to: Spatio-Temporal Study of Galactolipid Biosynthesis in Duckweed Using Mass Spectrometry Imaging and in vivo Isotope Labeling. [PDF]

Plant Cell Physiol
europepmc   +1 more source