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Antibody Isotypes for Tumor Immunotherapy
Transfusion Medicine and Hemotherapy, 2017 Compared to the evolutionary diversity of antibody isotypes, the spectrum of currently approved therapeutic antibodies is biased to the human IgG1 isotype. Detailed studies into the different structures and functions of human isotypes have suggested that
Thomas Valerius +2 more
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Isotype Determination of Antibodies
Current Protocols in Immunology, 1992AbstractOn identifying a new monoclonal antibody, or in characterizing antibodies in sera evoked by disease or immunization, it is particularly informative to determine the serological class of the antibodies. The serological class of the protein is determined by the structure of the antibody constant region.
Peter, Hornbeck +2 more
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Molecular Immunology, 1986
In 1974 Jerne proposed that the immune system functions as a network of interacting antibody combining sites (paratopes); each paratope reacts with determinants (idiotopes) borne by V regions of immunoglobulins (Ig)* and expresses idiotopes which are recognized by paratopes of other Ig (Jerne, 1974).
W H, Fridman +4 more
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In 1974 Jerne proposed that the immune system functions as a network of interacting antibody combining sites (paratopes); each paratope reacts with determinants (idiotopes) borne by V regions of immunoglobulins (Ig)* and expresses idiotopes which are recognized by paratopes of other Ig (Jerne, 1974).
W H, Fridman +4 more
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Regulation of isotype switching
Current Opinion in Immunology, 1992In the past year, our understanding of the mechanisms that regulate isotype switching has significantly progressed. Activation of germ line transcription by isotype-specific cytokines is emerging as a crucial mechanism for increasing the accessibility of a particular switch region, and targeting switch recombination.
D, Vercelli, R S, Geha
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Evolution of isotype switching
Seminars in Immunology, 2004This review discusses evolution of the process of Ig heavy chain class switching, relating it to the first appearance of somatic hypermutation (SHM) of variable region genes. First, we discuss recent findings on the mechanism of class switch recombination (CSR) in mice and humans, and then review the mechanisms of expression of Ig heavy chain isotypes ...
Stavnezer, Janet, Amemiya, Chris T.
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Immunoglobulin Isotype Expression
1978Many different kinds of observations suggest that during development of the B cell line, individual V H genes determining the antibody specificity of an immunoglobulin molecule can be expressed with multiple C H genes. Thus each clone of B cells, defined by expression of a variable-region gene for the light and heavy chains of the immunoglobulin ...
J F, Kearney, E R, Abney
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Information Design Journal, 1981
Isotype has been a purely historical phenomenon for about ten years. It proposed a system for presenting information in visual form; but how can designers now learn from this work ? It is argued that Isotype cannot be fully articulated as method, and that it should be understood rather as approach.
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Isotype has been a purely historical phenomenon for about ten years. It proposed a system for presenting information in visual form; but how can designers now learn from this work ? It is argued that Isotype cannot be fully articulated as method, and that it should be understood rather as approach.
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TAXON, 1969
SummaryThe term isopleths is proposed as a general term for specimens bearing the same collector's or collection number. Examples are given of isopleths of holotypes which are not isotypes, i.e. which were not seen by the original author of the name in question.
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SummaryThe term isopleths is proposed as a general term for specimens bearing the same collector's or collection number. Examples are given of isopleths of holotypes which are not isotypes, i.e. which were not seen by the original author of the name in question.
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Juni : Magazin für Literatur und Kultur, 2019
Der Beitrag untersucht die politischen Implikationen von Otto Neuraths visueller ...
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Der Beitrag untersucht die politischen Implikationen von Otto Neuraths visueller ...
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