Results 221 to 230 of about 20,504 (258)

Recent Advances in the Domino Annulation Reaction of Quinone Imines. [PDF]

Molecules
Wang ZH, Fu XH, Li Q, You Y, Yang L, Zhao JQ, Zhang YP, Yuan WC.   +7 more
europepmc   +1 more source

Efficacy of oral afoxolaner against Amblyomma maculatum infestations in dogs. [PDF]

Parasite
Tielemans E, Dumont P, Rautenbach C, Viljoen A, Prullage J.   +4 more
europepmc   +1 more source

The ability of an oral combination of afoxolaner, moxidectin and pyrantel to protect dogs from Borrelia burgdorferi infections transmitted by Ixodes scapularis. [PDF]

Parasit Vectors
Prullage J, Dumont P, Nair A, Liu M, DiCosty U, Süssenberger R.   +5 more
europepmc   +1 more source

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Tunable Key [3 + 2] and [2 + 1] Cycloaddition of Enaminones and α-Diazo Compounds for the Synthesis of Isomeric Isoxazoles: Metal-Controlled Selectivity.

Organic Letters, 2023
The three-component reactions of enaminones, α-diazo esters/ketones, and t-butyl nitrite (TBN) for the switchable synthesis of isomeric isoxazoles have been realized.
Wenli Song, Yunyun Liu, Nan Yan, Jie‐Ping Wan   +3 more
semanticscholar   +1 more source

Synthesis of (4-Trifluoromethyl)isoxazoles through a Tandem Trifluoromethyloximation/Cyclization/Elimination Reaction of α,β-Unsaturated Carbonyls.

Journal of Organic Chemistry, 2023
We disclose a metal-free, cascade regio- and stereoselective trifluormethyloximation, cyclization, and elimination strategy with readily available α,β-unsaturated carbonyl compounds to access a wide variety of pharmaceutically potential heteroaromatics ...
Paramita Pattanayak, T. Chatterjee
semanticscholar   +1 more source

Synthesis of Isoxazoles via One-Pot Oxidation/Cyclization Sequence from Propargylamines.

Journal of Organic Chemistry, 2022
A facile strategy for the synthesis of isoxazoles has been efficaciously developed, which involves oxidation of propargylamines to the corresponding oximes followed by CuCl-mediated intramolecular cyclization of the latter.
Mengyan Duan, G. Hou, Yabiao Zhao, Congjun Zhu, Chuanjun Song   +4 more
semanticscholar   +1 more source

Ring-Opening Fluorination of Isoxazoles.

Organic Letters, 2022
A ring-opening fluorination of isoxazoles has been developed. Upon treatment of isoxazoles with an electrophilic fluorinating agent (Selectfluor), fluorination followed by deprotonation leads to tertiary fluorinated carbonyl compounds.
Masaaki Komatsuda, Hugo Ohki, Hiroki Kondo, A. Suto, Junichiro Yamaguchi   +4 more
semanticscholar   +1 more source

Copper-Catalyzed Reductive Ring-Cleavage of Isoxazoles: Synthesis of Fluoroalkylated Enaminones and Application for the Preparation of Celecoxib, Deracoxib, and Mavacoxib.

Journal of Organic Chemistry, 2021
We have identified a new reactivity of copper/diamine catalysis for the reductive ring-cleavage of isoxazoles to yield fluoroalkylated enaminones.
C. Wan, Jian Pang, Wei-Qi Jiang, Xiao-Wei Zhang, Xiangguo Hu   +4 more
semanticscholar   +1 more source

Intermolecular [5 + 1]-Cycloaddition between Vinyl Diazo Compounds and tert-Butyl Nitrite to 1,2,3-Triazine 1-Oxides and Their Further Transformation to Isoxazoles.

Organic Letters, 2021
1,2,3-Triazine 1-oxides are formed by nitrosyl addition from tert-butyl nitrite to the vinylogous position of vinyl diazo compounds. This transformation, which is a formal intermolecular [5 + 1] cycloaddition, occurs under mild conditions, with high ...
Luca De Angelis, Haifeng Zheng, Matthew T Perz, Hadi D Arman, M. Doyle   +4 more
semanticscholar   +1 more source