Results 161 to 170 of about 1,834 (212)

Photochemistry of condensed isoxazolines

Monatshefte für Chemie Chemical Monthly, 1994
The condensed bridged isoxazolines4 are rearranged on irradiation with a low-pressure mercury lamp exclusively into condensed derivatives of tetrahydropyridine5. The selectivity of the rearrangement is due to a stabilization of the biradical8 by the overlap of the radical-electrons with π-electrons of the C=C double bond and the heterocyclic ring ...
V. Ondruš, L'. Fišera, N. Prónayová
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2‐Isoxazolines: A Synthetic and Medicinal Overview

ChemMedChem, 2020
AbstractIsoxazolines are nitrogen‐ and oxygen‐containing five‐membered heterocyclic scaffolds with extensive biological activities. This framework can be readily obtained in good to excellent yields through 1,3‐dipolar cycloaddition between nitrones with alkynes or allenes, aryl/alkyl halides, alkynes, and oxaziridines under mild conditions.
Gulshan Kumar, Ravi Shankar
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Isoxazolines and isoxazoles as factor Xa inhibitors

Bioorganic & Medicinal Chemistry Letters, 2000
3,4,5-Trisubstituted isoxazolines (2) and isoxazoles (3) were prepared and evaluated for their in vitro and in vivo antithrombotic efficacy. They were compared to 3,5,5-trisubstituted isoxazolines (1) for Factor Xa selectivity and potency. They were also compared in an arterio-venous (A-V) shunt model of thrombosis.
J R, Pruitt, D J, Pinto, M J, Estrella, L L, Bostrom, R M, Knabb, P C, Wong, M R, Wright, R R, Wexler   +7 more
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Asymmetric synthesis of chiral spiro bis(isoxazoline) and spiro (isoxazole–isoxazoline) ligands

Tetrahedron: Asymmetry, 2010
Abstract Asymmetric synthesis of novel chiral ligands, bis(isoxazoline) on a spiro[4.4]nonane scaffold and isoxazole–isoxazoline on a spiro[4.5]decane scaffold, has been achieved by utilizing an enantiomerically pure alcohol as the starting material.
Kazuhiro Takenaka, Toyohiro Nagano, Shinobu Takizawa, Hiroaki Sasai   +3 more
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Synthesis of isoxazoline analogs of stellettins

Organic & Biomolecular Chemistry
(±)-Stellettin analogs featuring an isoxazoline ring were synthesized. Pharmacological evaluation of the analogs revealed that the α,β-unsaturated ketone structures in stellettins might be important to their cytotoxic activity.
Yuan Wang, Zhe Wang, Miao Zhuang, Xinyi Deng, Xiaoyu Liu, Xiaozhen Jiao, Ping Xie   +6 more
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2‐Isoxazoline derivatives. Part I. A base‐promoted fragmentation of 2‐isoxazolines

Journal of Heterocyclic Chemistry, 1968
AbstractThe action of bases on 3‐aryl (or alkyl)‐5‐acyl‐2‐isoxazolines has been shown to give rise to the corresponding aromatic (or aliphatic) nitriles and α‐diketones by cleavage of the O‐N and C3C4 bonds of the heterocyclic ring. This fragmentation reaction has been extended to other 2‐isoxazolines substituted in the 5‐position with electron ...
Giorgio Bianchi, Remo Gandolfi, Paolo Grünanger   +2 more
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Unusual transformations of 2-isoxazolines

Russian Chemical Reviews, 1997
The data on unusual transformations of 2-isoxazolines observed in both their preparation by traditional methods and various reactions, mostly with nucleophilic reagents, are considered systematically. Possible mechanisms of these reactions are discussed.
Elena V Koroleva, Fedor A Lakhvich
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Structure and stability of isoxazoline compounds

Russian Journal of General Chemistry, 2013
Structure of isoxazoline compounds formed via the reaction of alkyl-substituted benzonitrile oxides with ethylene was determined by X-ray diffraction method. Isoxazoline ring is flattened, the bond lengths in it depend slightly on the nature of substituents (CH3, C2H5) and their position in the benzene ring and the angle of rotation relative to the ...
T. K. Goncharov, V. V. Dubikhin, E. L. Ignat’eva, G. M. Nazin, Z. G. Aliev, S. M. Aldoshin   +5 more
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Isoxazoline: A Privileged Scaffold for Agrochemical Discovery

Journal of Agricultural and Food Chemistry
Isoxazolines are an important class of nitrogen- and oxygen-containing heterocycles that belong to the azole family. Recently, it has gained great attention in the field of agrochemical development. However, systematic reviews on the advancements of isoxazolines containing bioactive molecules are relatively lacking. To provide insight into advancements
Li Xiong, Rui Zhang, Kai-Long Zhang, Baohui Qi   +3 more
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Isoxazoline: An Emerging Scaffold in Pesticide Discovery

Journal of Agricultural and Food Chemistry
Isoxazolines are five-membered heterocycle compounds with a wide range of pharmacological and pesticidal activities. Numerous marketed pesticides contain an isoxazoline motif as a key skeleton. Isoxazoline compounds have relatively simple syntheses and wide biological activities against various weeds, bacteria, and other pests.
Ling-Jie Kong, Xin-Yu Cao, Na-Bo Sun, Li-Jing Min, Stephen O. Duke, Hong-Ke Wu, Li-Qin Zhang, Xing-Hai Liu   +7 more
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