Genetics of isozymes in grasspea [PDF]
We studied the inheritance and linkage of ACO-1, ACO-2, AAT-1, AAT-2, EST-3, EST-6, FDH, LAP-1, PGD-2, SKDH, and TPI-1 in four F2 populations of grasspea (Lathyrus sativus L.) using horizontal starch-gel electrophoresis. Mendelian inheritance was observed for all of the isozymes studied.
MA Chowdhury, A. E. Slinkard
openaire +3 more sources
Potent Fluorescent Probe for Target‐Engagement Studies of Allosteric Pyruvate Kinase Modulators
LumiPK, a novel environment‐sensitive fluorescent tracer, enables direct monitoring of allosteric ligand engagement with pyruvate kinase fused with nanoluciferase (Nluc), focusing on the liver isoform (PKL). In NanoBRET, and fluorescence indicator displacement assays, LumiPK shows high affinity and validates known allosteric modulators of PKL.
Oscar Nilsson+9 more
wiley +2 more sources
A role for glyceraldehyde-3-phosphate dehydrogenase in the development of thermotolerance in Xenopus laevis embryos [PDF]
During heat shock, Xenopus laevis embryos exhibit an increase in the rate of accumulation of lactate and a loss of ATP relative to non-heat- shocked control embryos.
Browder, Leon W., Nickells, Robert W.
core +2 more sources
Genetic variation within and among naturally regenerating populations of alder (Alnus glutinosa)
To assess the inter- and intrapopulation genetic variation in the filial generation (F1) of alder (Alnus glutinosa (L.) Gaertn.), 11 naturally regenerated populations were analysed. Their parental populations (P), represent the whole Polish territory and
Leon Mejnartowicz
doaj +1 more source
Low Degree Metabolites Explain Essential Reactions and Enhance Modularity in Biological Networks [PDF]
Recently there has been a lot of interest in identifying modules at the level of genetic and metabolic networks of organisms, as well as in identifying single genes and reactions that are essential for the organism.
Giri, Varun+5 more
core +4 more sources
INHERITANCE OF ISOZYMES: DESCRIPTION OF NEW LOCI IN ONIONS ISOZYMES [PDF]
Horizontal starch gel electrophoresis was used to study the mode of inheritance of isozyme phenotypes of four enzyme systems (ADH, 6-PGDH, PGM, and SKDH) in Allium cepa L. and A. fistulosum L. by monitoring segregations in backcross and F2 progeny. Segregation for most of the polymorphisms fit the expected Mendelian ratios as tested by the chi-square ...
Paul D. Mangum, Ellen B. Peffley
openaire +2 more sources
Evocalcet is a novel calcimimetic agent for the treatment of secondary hyperparathyroidism (SHPT). This study evaluated the effects of evocalcet on inhibition and induction of cytochrome P450 (CYP) isozymes.
Kazuya Narushima+11 more
doaj +1 more source
Insulin Action on Polyunsaturated Phosphatidic Acid Formation in Rat Brain: An “In Vitro” Model with Synaptic Endings from Cerebral Cortex and Hippocampus [PDF]
The highly efficient formation of phosphatidic acid from exogenous 1-stearoyl-2-arachidonoyl-sn-glycerol (SAG) in rat brain synaptic nerve endings (synaptosomes) from cerebral cortex and hippocampus is reported.
Giusto, Norma Maria+2 more
core +1 more source
Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents. [PDF]
Following our previous research on anti-inflammatory drugs (NSAIDs), we report here the synthesis of chiral 1,5-diarylpyrroles derivatives that were characterized for their in vitro inhibitory effects toward cyclooxygenase (COX) isozymes.
ANZELLOTTI P.+20 more
core +1 more source
The genetic population structure of the pink snail Strombus gigas in the Yucatan Peninsula, Mexico, was determined by isozyme expression in polyacrylamide gels.
Jorge A Tello-Cetina+2 more
doaj +1 more source