Modulation of Cell Components and Specific Isoforms of Antioxidant Enzymes in Safflower Under Water Stress and Recovery [PDF]
Journal of Stress Physiology & Biochemistry, 2021 Drought tolerance represents a growing threat to crop productivity. Safflower is one of the major oilseed crop enriched with various nourishing elements.
Thippeswamy M. +3 more
doaj
Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents. [PDF]
, 2008 Following our previous research on anti-inflammatory drugs (NSAIDs), we report here the synthesis of chiral 1,5-diarylpyrroles derivatives that were characterized for their in vitro inhibitory effects toward cyclooxygenase (COX) isozymes.
ANZELLOTTI P. +20 more
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Variabilidade Genética em Populações Naturais de Cassia grandis L. f.
Floresta e Ambiente, 2018 RESUMO O delineamento de estratégias para a conservação genética de uma espécie requer o conhecimento de aspectos ecológicos e genéticos de suas populações.
Itamara Bomfim Gois +2 more
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Design and synthesis of diazine-based panobinostat analogues for HDAC8 inhibition
Beilstein Journal of Organic Chemistry, 2020 Guided by computational analysis, herein we report the design, synthesis and evaluation of four novel diazine-based histone deacetylase inhibitors (HDACis). The targets of interest (TOI) are analogues of panobinostat, one of the most potent and versatile
Sivaraman Balasubramaniam +8 more
doaj +1 more source
Limitation of F1 hybrids uniformity law [PDF]
, 2011 Using isozymes as markers, data indicative of polymorphisms in the progeny produced from crossing two beet plants, homozygous on contrastive alleles of enzyme loci, were ...
Evgenii Levites
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DADA Enhances CD8+ T Cell Stemness to Improve Anti‐Tumor Immunity and Immunotherapy Efficacy
Advanced Science, EarlyView.Diisopropylamine dichloroacetate (DADA) enhances CD8+ T cell stemness by improving OXPHOS and mitochondrial fitness in a PDK1‐depenpendent manner. This metabolic shift strengthens CD8+ T cell anti‐tumor immunity, improves responses to PD‐1 blockade, and endows CAR‐T cells with prolonged persistence and resistance to terminal exhaustion, highlighting a ...
Mingyue Bi +12 more
wiley +1 more source
Distinct forebrain and cerebellar isozymes of type II Ca^(2+)/calmodulin-dependent protein kinase associate differently with the postsynaptic density fraction [PDF]
, 1985 Forebrain and cerebellar Type II Ca2+/calmodulin-dependent protein kinases have different subunit compositions. The forebrain holoenzyme, characterized in our laboratory, is a 650-kDa holoenzyme composed of 50-kDa alpha-subunits and 60-kDa beta-subunits ...
Kennedy, Mary B., Miller, Stephen G.
core
Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Gαs/Gαq-mediated protein kinases A/C. [PDF]
, 2013 VLGR1 (very large G protein-coupled receptor 1), also known as MASS1 (monogenic audiogenic seizure susceptible 1), is an orphan G protein-coupled receptor that contains a large extracellular N terminus with 35 calcium-binding domains.
Fu, Ying-Hui +3 more
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Advanced Science, EarlyView.After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng +9 more
wiley +1 more source
Memorias do Instituto Oswaldo Cruz, 2005 Anopheles (Anopheles) intermedius and Anopheles (Ano.) mattogrossensis are Brazilian anopheline species belonging to the scarcely studied Anopheles subgenus. Few studies have been done on the genetic differentiation of these species.
Joselita Maria Mendes dos Santos +3 more
doaj +1 more source