Results 51 to 60 of about 35,897 (231)

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo   +5 more
wiley   +1 more source

Characterization of potato genotypes using molecular markers Caracterização de genótipos de batata por marcadores moleculares

open access: yesPesquisa Agropecuária Brasileira, 2004
The objective of this work was to characterize 27 potato genotypes, using molecular markers. Polyacrylamide gel electrophoresis, RAPD techniques and isozymes of esterase, phosphoglucomutase and soluble proteins were analyzed in tubers, and isocitrate ...
Eliana Antonia Silveira Collares   +2 more
doaj   +1 more source

Identification of genetic characteristics of maize (Zea mays L) using genetic markers [PDF]

open access: yesZbornik Matice Srpske za Prirodne Nauke, 2002
Different genetic markers are used for estimation of breeding material, its characteristics and potential for ultimate aim - heterosis of hybrids. They also point out to the qualitative seed traits at the level of linkage with genes responsible for ...
Zlokolica Marija Ž.   +3 more
doaj   +1 more source

Organelle- and Organ-Specific Isozymes of Euglena Gracilis and Catfish [PDF]

open access: yes, 1974
Two distinct compartmentalized isozymes of aldolase and triosephosphate isomerase were examined in the photoautotrophically and heterotrophically grown green alga Euglena gracilis.
Mo, Yeh-Chun
core  

Percent activity observed with different DNMT isozymes.

open access: yes, 2019
Percent activity observed with different DNMT isozymes.
Rebecca L. Switzer (6954794)   +3 more
core   +1 more source

A new branch of mammalian vitamin B6 metabolism: AKR1C‐mediated conversion of pyridoxal to pyridoxine and 4‐pyridoxolactone

open access: yesThe FEBS Journal, EarlyView.
Pyridoxal 5′‐phosphate (PLP) homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and dehydrogenase activities.
Nayu Kito   +8 more
wiley   +1 more source

Phospholipase A(2) isozymes in pregnancy and parturition

open access: yes, 2004
Mammalian cells contain several structurally different phospholipase (PLA(2)) enzymes that exhibit distinct localisation, function and mechanisms of regulation.
G.E Rice   +3 more
core   +1 more source

ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis

open access: yesThe FEBS Journal, EarlyView.
The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati   +4 more
wiley   +1 more source

Immunological Properties of Lactate Dehydrogenase Isozymes in Trout

open access: yes, 1978
Evolutionary and immunological relationships among the different genes specifying synthesis of rainbow trout (Salmo gairdneri) LDH subunits were demonstrated.
Braune, M. O., Heckman, J. R.
core   +1 more source

Protein electrophoresis AIDS cereal variety identification

open access: yesCalifornia Agriculture, 1973
Enzyme proteins obtained from seedling plants show distinct patterns (isozymes) after migration in an electric field. Crop varieties differ in isozymes, and these differences open new possibilities for “fingerprinting” varieties for identification ...
J Menke, R Singh, C Qualset, S Jain
doaj  

Home - About - Disclaimer - Privacy