Results 61 to 70 of about 77,640 (305)

TRPV1 activity and substance P release are required for corneal cold nociception

Nature Communications, 2019
The eye shows protective responses to noxious stimuli including cold. Here, the authors show that TRPV1, found co-expressed on TRPM8 + fibres in the cornea, is necessary for cold nociception in the eye.
Fengxian Li, Weishan Yang, Haowu Jiang, Changxiong Guo, Andrew J. W. Huang, Hongzhen Hu, Qin Liu   +6 more
doaj   +1 more source

Face Mask-induced Itch: A Self-questionnaire Study of 2,315 Responders During the COVID-19 Pandemic

Acta Dermato-Venereologica, 2020
Little is known about itch related to the use of face masks. This internet survey study investigated the prevalence, intensity and clinical characteristics of itch related to the use of face masks by the general public during the COVID-19 pandemic.
J. Szepietowski, Ł. Matusiak, M. Szepietowska, P. Krajewski, Rafał BIAŁYNICKI-BIRULA   +4 more
semanticscholar   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Activation of NPY2R-expressing amygdala neurons inhibits itch behavior in mice without lateralization

Scientific Reports
The central amygdala (CeA) is a crucial hub in the processing of affective itch, containing a diverse array of neuronal populations. Among these components, Neuropeptide Y (NPY) and its receptors, such as NPY2R, affect various physiological and ...
Darya Pavlenko, Zeynep Gizem Todurga-Seven, Kristen Sanders, Anika Markan, Rebecca Verpile, Hirotake Ishida, Dylan Costo, Tasuku Akiyama   +7 more
doaj   +1 more source

Sex differences in itch perception and modulation by distraction--an FMRI pilot study in healthy volunteers.

PLoS ONE, 2013
BackgroundEven though itch is a common syndrome of many diseases there is only little knowledge about sex and gender differences in pruritus, especially in central itch perception and modulation.
Astrid Stumpf, Markus Burgmer, Gudrun Schneider, Gereon Heuft, Martin Schmelz, Ngoc Quan Phan, Sonja Ständer, Bettina Pfleiderer   +7 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Novel Topical Treatments for Itch

Dermatology and Therapy
The experience of itch often poses a burden on patient quality of life and has the capacity to inflict significant suffering. Topical therapies are a mainstay of treatment for many cutaneous and systemic diseases and afford patients the opportunity to ...
Rami H. Mahmoud, Omar Mahmoud, Georgia Biazus Soares, Gil Yosipovitch   +3 more
doaj   +1 more source

Central circuit mechanisms of itch

Nature Communications, 2020
Itch, in particular chronic forms, has been widely recognized as an important clinical problem, but much less is known about the mechanisms of itch in comparison with other sensory modalities such as pain. Recently, considerable progress has been made in
Xiao-Jun Chen, Yan-Gang Sun
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Decreased Responsiveness to Chemical Itch in Old Mice

Cells
Aging is associated with altered itch perception, potentially due to changes in neuronal function and pruriceptive signaling. The underlying mechanisms, however, remain unclear.
Qiaofeng Zhao, Mitsutoshi Tominaga, Sumika Toyama, Kotaro Honda, Eriko Komiya, Yayoi Kamata, Hang Ma, Kenji Takamori   +7 more
doaj   +1 more source