Results 61 to 70 of about 135,785 (350)

TRPV1 activity and substance P release are required for corneal cold nociception

Nature Communications, 2019
The eye shows protective responses to noxious stimuli including cold. Here, the authors show that TRPV1, found co-expressed on TRPM8 + fibres in the cornea, is necessary for cold nociception in the eye.
Fengxian Li, Weishan Yang, Haowu Jiang, Changxiong Guo, Andrew J. W. Huang, Hongzhen Hu, Qin Liu   +6 more
doaj   +1 more source

A Narrative Review of Placebo and Nocebo Effects on Itch [PDF]

, 2023
Jessica A. Dietz, Alisha Halver, Kimberly Hammer, Natasha Petry, Sara Westall, Tze Shien Lo   +5 more
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Activation of NPY2R-expressing amygdala neurons inhibits itch behavior in mice without lateralization

Scientific Reports
The central amygdala (CeA) is a crucial hub in the processing of affective itch, containing a diverse array of neuronal populations. Among these components, Neuropeptide Y (NPY) and its receptors, such as NPY2R, affect various physiological and ...
Darya Pavlenko, Zeynep Gizem Todurga-Seven, Kristen Sanders, Anika Markan, Rebecca Verpile, Hirotake Ishida, Dylan Costo, Tasuku Akiyama   +7 more
doaj   +1 more source

Aquarium dermatitis: Cercarial dermatitis in an aquarist [PDF]

, 1998
A 33-year-old man presented with very itchy red papules on the back of his hands and forearms. These papules appeared about 90 min after he had cleaned his aquarium in which he kept native fish and watersnails.
Bastert, J., Korting, Hans Christian, Sing, A., Wollenberg, A.   +3 more
core   +1 more source

BNP facilitates NMB-mediated histaminergic itch via NPRC-NMBR crosstalk [PDF]

, 2021
Qingtao Meng, Xianyu Liu, Xue-Ting Liu, Devin M. Barry, Hua Jin, Yu Sun, Qianyi Yang, Li Wan, Jinhua Jin, Kai‐Feng Shen, Admire Munanairi, W. Ray Kim, Jun Yin, Ailin Tao, Zhou‐Feng Chen   +14 more
openalex   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Decreased Responsiveness to Chemical Itch in Old Mice

Cells
Aging is associated with altered itch perception, potentially due to changes in neuronal function and pruriceptive signaling. The underlying mechanisms, however, remain unclear.
Qiaofeng Zhao, Mitsutoshi Tominaga, Sumika Toyama, Kotaro Honda, Eriko Komiya, Yayoi Kamata, Hang Ma, Kenji Takamori   +7 more
doaj   +1 more source

Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons [PDF]

, 2014
The peripheral terminals of primary sensory neurons detect histamine and non-histamine itch-provoking ligands through molecularly distinct transduction mechanisms.
Bean, Bruce P., Binshtok, Alexander M., Blasl, Felix, Duan, Bo, Gudes, Sagi, Ma, Qiufu, Oh, Seog Bae, Patoski, Haley A. W., Roberson, David P., Robson, Victoria K., Sprague, Jared M., Woolf, Clifford J.   +11 more
core   +1 more source