Results 121 to 130 of about 25,829,571 (300)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

ABCR Item Analysis.

open access: yes, 2015
Note. SD = Standard Deviation, PCC = Polyserial Correlation CoefficientABCR Item Analysis.
Yasushi Abe (780661)   +4 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Mensuração de conforto e desconforto em poltrona de aeronave pela teoria da resposta ao item [PDF]

open access: yes, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Produção, Florianópolis, 2013.Este estudo desenvolveu instrumentos de medida de conforto edesconforto em poltrona de aeronave com ...
Menegon, Lizandra da Silva
core  

Item selection from Rasch analysis.

open access: yes, 2018
Item selection from Rasch analysis.
Katsuyoshi Tanaka (4173133)   +5 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Rasch analysis GSS item statistics.

open access: yes, 2019
Rasch analysis GSS item statistics.
Miroslav Stamenkovic (6714572)   +6 more
core   +1 more source

Comparison of Item Difficulty Analyses of Exams Used in Teaching Turkish as a Foreign Language with Instructors’ Perceptions of Item Difficulty

open access: yesSakarya University Journal of Education
In numerous studies focusing on assessment and evaluation of teaching Turkish as a foreign language, researchers have frequently identified issues related to the standardization and low validity and reliability of exams.
Seçil Alaca, Funda Keskin
doaj   +1 more source

Home - About - Disclaimer - Privacy