Results 81 to 90 of about 2,443,182 (340)

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Exploring differential item functioning in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)

BMC Musculoskeletal Disorders, 2012
Background The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) is a widely used patient reported outcome in osteoarthritis. An important, but frequently overlooked, aspect of validating health outcome measures is to establish if ...
Pollard Beth, Johnston Marie, Dixon Diane   +2 more
doaj   +1 more source

The efficacy and safety of telerehabilitation for patients following total knee arthroplasty: a overviews of systematic reviews

BioMedical Engineering OnLine, 2023
Background Studies evaluating the effectiveness and safety of telerehabilitation in patients undergoing total knee arthroplasty (TKA) have increased. However, the study quality and results differ, systematic reviews are limited.
Danli Pang, Aiping Sun, Fei Wang, Jingyu Lu, Yaorui Guo, Wen Ding   +5 more
doaj   +1 more source

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Unbiased Analysis of Item-Specific Multi-Voxel Activation Patterns Across Learning

Frontiers in Neuroscience, 2018
Recent work has highlighted that multi-voxel pattern analysis (MVPA) can be severely biased when BOLD response estimation involves systematic imbalance in model regressor correlations.
Hannes Ruge, Eric Legler, Theo A. J. Schäfer, Katharina Zwosta, Uta Wolfensteller, Holger Mohr   +5 more
doaj   +1 more source

Effects of Initial Values and Convergence Criterion in the Two-Parameter Logistic Model When Estimating the Latent Distribution in BILOG-MG 3. [PDF]

PLoS ONE, 2015
Parameters of the two-parameter logistic model are generally estimated via the expectation-maximization algorithm, which improves initial values for all parameters iteratively until convergence is reached.
Ingo W Nader, Ulrich S Tran, Martin Voracek   +2 more
doaj   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Studi Tentang Dampak Dari Multidimensionalitas Butir Soal Terhadap Estimasi True Skor Dengan Pendekatan Model Bifaktor

Jurnal Pengukuran Psikologi dan Pendidikan Indonesia, 2019
Penelitian ini merupakan penelitian simulasi dimana yang menjadi fokus dalam penelitian ini adalah banyaknya faktor, item dan responden dengan replikasi 50 kali.
Nursakinah Oktaviana Sasmita
doaj   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Invariance and item bias of the Mental Health Continuum Short-Form for South African university first-year students

African Journal of Psychological Assessment
Over the last decade, higher education institutions (HEIs) have become increasingly interested in student well-being. However, since the student population is very diverse in South Africa, questionnaires measuring the well-being of students must be ...
Karina Mostert, Leon de Beer, Ronalda de Beer   +2 more
doaj   +1 more source