Results 71 to 80 of about 1,038,246 (291)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Ensuring the quality of multiple-choice exams administered to small cohorts: A cautionary tale

Perspectives on Medical Education, 2017
Introduction Multiple-choice questions (MCQs) are a cornerstone of assessment in medical education. Monitoring item properties (difficulty and discrimination) are important means of investigating examination quality.
Meredith Young, Beth-Ann Cummings, Christina St-Onge   +2 more
doaj   +1 more source

Introducing a framework to assess newly created questions with Natural Language Processing

, 2020
Statistical models such as those derived from Item Response Theory (IRT) enable the assessment of students on a specific subject, which can be useful for several purposes (e.g., learning path customization, drop-out prediction).
A Abyaa, CD Manning, GH Mc Laughlin, J Bergstra, J Verhagen, R Flesch, RC Atkinson, RK Hambleton, X Wang, Y Mao, Z Huang   +10 more
core   +1 more source

Standard setting in Australian medical schools [PDF]

, 2018
Background: Standard setting of assessment is critical in quality assurance of medical programs. The aims of this study were to identify and compare the impact of methods used to establish the passing standard by the 13 medical schools who participated ...
Chiavaroli, Neville, Fraser, James, Mansfield, Kylie, O\u27Mara, Deborah, Starmer, Darren, Surmon, Laura, Veysey, Martin, Ward, Helena   +7 more
core   +5 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Item Response Theory for trait assessment in randomized item pool for computer based test

Scientific African
The rapid adoption of computer-based examinations (CBE) has raised concerns regarding fairness and reliability in assessing student performance. This study examines randomized test item fairness to test takers’ traits in CBE through the application of ...
Rhydal Esi Eghan, Edward Osei-Sarpong, Gaston Edem Awashie, Reindorf Nartey Borkor, Evans Yaokumah, Aditta Abigail N’ganomah   +5 more
doaj   +1 more source

Reengineering the Glaucoma Quality of Life-15 Questionnaire with Rasch Analysis [PDF]

, 2011
This article is made available with the permission of the publisher, Association for Research in Vision and OphthalmologyPurpose.: To investigate, using Rasch analysis, whether the 15-item Glaucoma Quality of Life-15 (GQL-15) forms a valid scale and to ...
Hirneiss, C, Kernt, M, Khadka, Jyoti, McAlinden, Colm, Pesudovs, Konrad, Vogel, M   +5 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Difficulties in Writing News Item Experienced by Students of A Vocational High School in Cirebon

IJET (Indonesian Journal of English Teaching), 2017
This study was qualitative research that used descriptive analysis.The present study aimed at investigating out the students’ difficulties in writing news item and find out the most dominant difficulty in writing news item made by the eleventh graders of
Syahfitri Anugerah Dewi, Misdi Misdi
doaj   +1 more source

TEST ITEM ANALYSIS PROGRAM DEVELOPMENT WITH RASCH MODEL ONE PARAMETER FOR TESTING THE ITEM DIFFICULTY LEVEL OF MULTIPLE-CHOICE TEST USING BLOODSHED DEV C ++ APPLICATIONS [PDF]

, 2014
This article was made in Item Response Theory lecture to improve the ability of students to learn the application of the theory of grain analyst using the model of Rasch model.
Dadan, Rosana, Otok, Ewi Amsirta
core