Results 131 to 140 of about 12,425,968 (292)
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Markov Chain Monte Carlo Estimation of Normal Ogive IRT Models in MATLAB [PDF]
Modeling the interaction between persons and items at the item level for binary response data, item response theory (IRT) models have been found useful in a wide variety of applications in various fields. This paper provides the requisite information and
Yanyan Sheng
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Item Response Data Analysis Using Stata Item Response Theory Package
, 2017 The purpose of this article is to introduce and review the capability and performance of the Stata item response theory ( irt) package that is available from Stata V.14, 2015.
Xiaying Zheng, Ji Seung Yang
core +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
A MATLAB Package for Markov Chain Monte Carlo with a Multi-Unidimensional IRT Model [PDF]
Unidimensional item response theory (IRT) models are useful when each item is designed to measure some facet of a unified latent trait. In practical applications, items are not necessarily measuring the same underlying trait, and hence the more general ...
Yanyan Sheng
core
Multidimensional item response theory /
, 2020 "Several decades of psychometric research have led to the development of sophisticated models for multidimensional test data, and in recent years, multidimensional item response theory (MIRT) has become a burgeoning topic in psychological and educational
Bonifay, Wesaut
core
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
, 2017 De wijzigingsvoorstellen voor Coördinatieverordening 883/2004 en de ex ante ...
ITEM, Montebovi, Saskia
core