Results 151 to 160 of about 1,160,716 (327)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

A preliminary study for refinement of Equity Preference Questionnaire: Application of Item response theory(IRT)

, 2016
SeungRib Park, Yongwon Suh
openalex   +2 more sources

Linking Pain Items from Two Studies Onto a Common Scale Using Item Response Theory [PDF]

, 2009
Wen-Hung Chen, Dennis A. Revicki, Jin‐Shei Lai, Karon F. Cook, Dagmar Amtmann   +4 more
openalex   +1 more source

Fluctuations of Ability Estimates in Testing in Item Response Theory

, 2023
Hideo Hirose
openalex   +2 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Estimating meaningful thresholds for multi-item questionnaires using item response theory [PDF]

, 2023
Berend Terluin, Jaimy E. Koopman, Lisa Hoogendam, Pip Griffiths, Caroline B. Terwee, Jakob Bue Bjørner   +5 more
openalex   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Development of a neuro-psychological diagnostic test for dementia based on working memory theory (TKW test) : Construction of specific concise versions for diagnosis of severity and etiology of dementia in terms of item response theory

, 2005
Yasue Yonekura, Yukito Shinohara, Masahiro Yamamoto, Hiroshi Namiki   +3 more
openalex   +2 more sources

Measuring the ICF components of impairment, activity limitation and participation restriction: an item analysis using classical test theory and item response theory [PDF]

, 2009
Beth Pollard, Diane Dixon, Paul Dieppe, Marie Johnston   +3 more
openalex   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source