Results 51 to 60 of about 1,166,070 (278)
Cambridge Prisms: Global Mental Health, 2020 BackgroundThere is a need for accurate and efficient assessment tools that cover a range of mental health and psychosocial problems. Existing, lengthy self-report assessments may reduce accuracy due to respondent fatigue.
Emily E. Haroz +5 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Modeling Composite Assessment Data Using Item Response Theory
CPT: Pharmacometrics & Systems Pharmacology, 2018 Composite assessments aim to combine different aspects of a disease in a single score and are utilized in a variety of therapeutic areas. The data arising from these evaluations are inherently discrete with distinct statistical properties.
Sebastian Ueckert
doaj +1 more source
Advances in item response theory and applications: an introduction [PDF]
, 1982 Test theories can be divided roughly into two categories. The first is classical test theory, which dates back to Spearman’s conception of the observed test score as a composite of true and error components, and which was introduced to psychologists at ...
Hambleton, Ronald K. +1 more
core +3 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Marker effects and examination reliability: a comparative exploration from the perspectives of generalizability theory, Rasch modelling and multilevel modelling [PDF]
, 2013 This study looked at how three different analysis methods could help us to understand rater effects on exam reliability. The techniques we looked at were: generalizability theory (G-theory) item response theory (IRT): in particular the Many-Facets ...
Baird, Jo-Anne +4 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
On the complementarity of classical test theory and item response models: item difficulty estimates and computerized adaptive testing [PDF]
, 2014 This study aims to provide statistical evidence of the complementarity between classical test theory and item response models for certain educational assessment purposes.
DINIS MOTA DA COSTA PATRICIA +1 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source