Results 81 to 90 of about 12,425,968 (292)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

A Comparison of Classical Test Theory and Nonparametric Item Response Theory with Respect to the Effects of Testees’ Characteristics on Item Characteristics and vice versa [PDF]

فصلنامه نوآوری‌های آموزشی, 2006
This study aimed at comparing Classical Test Theory and Nonparametric Item Response Theory with respect to the effect of testees’ characteristics on item characteristics and vice versa. The research method was of the applied, descriptive type.
Ali delavar, Ali Moghaddamzadeh, Seyedeh Tayebeh Motiee Langroudi   +2 more
doaj  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Avaliação de desempenho logístico no serviço ao cliente baseada na teoria da resposta ao item [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Produção, Florianópolis, 2011A busca por alternativas para avaliar o desempenho logístico foi o que instigou esta pesquisa.
Vey, Ivan Henrique
core  

Using item response theory to explore the psychometric properties of extended matching questions examination in undergraduate medical education [PDF]

, 2005
BACKGROUND: As assessment has been shown to direct learning, it is critical that the examinations developed to test clinical competence in medical undergraduates are valid and reliable. The use of extended matching questions (EMQ) has been advocated to
Tennant, A., Mike Horton, Horton, M., Lawton, G., Tennant Alan, Gemma Lawton, David Andrich, Alan Tennant, Horton Mike, Bipin Bhakta, Lawton Gemma, Bhakta, B., Andrich, D., Bhakta Bipin, Andrich David   +14 more
core   +2 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

PENGEMBANGAN TES BERPIKIR KRITIS DENGAN PENDEKATAN ITEM RESPONSE THEORY

Jurnal Penelitian dan Evaluasi Pendidikan, 2016
Penelitian ini bertujuan untuk menghasilkan sebuah alat ukur (tes) berpikir kritis yang valid dan reliabel untuk digunakan, baik dalam lingkup pendidikan maupun kerja di Indonesia.
Fajrianthi Fajrianthi, Wiwin Hendriani, Berlian Gressy Septarini   +2 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Marginal Maximum Likelihood Estimation of Item Response Models in R [PDF]

Item response theory (IRT) models are a class of statistical models used by researchers to describe the response behaviors of individuals to a set of categorically scored items.
Matthew S. Johnson
core