Results 61 to 70 of about 321,959 (297)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Geodesy and Cartography, 2012 The paper analyzes the case of mathematical procedures. An appropriate minimizing function is used for solving optimization tasks. In some cases, for example dealing with tasks of topological transformation, the applied minimizing function has no point ...
Jonas Skeivalas
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Iteration and Iterative Roots of Fractional Polynomial Function [PDF]
International Journal of Mathematics and Mathematical Sciences, 2012 Iteration is involved in the fields of dynamical systems and numerical computation and so forth. The computation of iteration is difficult for general functions (even for some simple functions such as linear fractional functions). In this paper, we discuss fractional polynomial function and use the method of conjugate similitude to obtain its ...
openaire +3 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Identifying and evaluating parallel design activities using the design structure matrix [PDF]
, 2005 This paper describes an approach based upon the Design Structure Matrix (DSM) for identifying, evaluating and optimising one aspect of CE: activity parallelism.
Whitfield, R.I. +2 more
core +2 more sources
Positive solutions for singular three-point boundary-value problems
Electronic Journal of Differential Equations, 2007 In this paper, we present the Green's functions for a second-order linear differential equation with three-point boundary conditions. We give exact expressions of the solutions for the linear three-point boundary problems by the Green's functions.
Zengqin Zhao
doaj
Convergence of infinite products of matrices and inner-outer iteration schemes [PDF]
, 1994 Elsner L, Bru R, Neumann MM. Convergence of infinite products of matrices and inner-outer iteration schemes. Electronic Transactions on Numerical Analysis.
Elsner, Ludwig +5 more
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source