Results 11 to 20 of about 46,843 (269)
Variability of Hydroxy-Itraconazole in Relation to Itraconazole Bloodstream Concentrations [PDF]
Antimicrobial Agents and Chemotherapy, 2021 We analyzed the relationship between itraconazole (ITZ) and hydroxy-itraconazole (OH-ITZ) levels in 1,223 human samples. Overall, there was a statistically significant correlation between ITZ and OH-ITZ levels (Pearson’s r , 0.7838), and OH-ITZ levels were generally higher than ITZ levels (median OH-ITZ:ITZ ratio, 1.
Nathan P. Wiederhold +3 more
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Antifungal activity of itraconazole compared with hydroxy-itraconazole in vitro [PDF]
Journal of Antimicrobial Chemotherapy, 2000 Microbroth dilution tests in vitro showed the same IC(50) values for itraconazole and hydroxy-itraconazole, within a mode +/- one dilution range of experimental error, for 90% of 1481 isolates of pathogenic fungi, representing 48 genera. Some 10-15% of Candida glabrata and Trichophyton mentagrophytes isolates were more susceptible to itraconazole than ...
Frank C. Odds, H. Vanden Bossche
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Cardiotoxicity with Itraconazole [PDF]
BMJ Case Reports, 2017 Itraconazole is a commonly used antifungal drug. In addition to commonly described adverse effects, there have been few reports of heart failure with its use. We present two cases that developed acute systolic heart failure with Itraconazole use. A man in his early 30s was admitted with worsening leg swelling and dyspnoea on exertion.
Harsh Rawal, Vishesh Paul
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Pifu-xingbing zhenliaoxue zazhi, 2020 Objective: To evaluate virulence of itraconazole-resistant Sporothrix globosa and its sensitivity to itraconazole in Galleria mellonella. Methods: Itraconazole-resistant strain and itraconazole-sensitive strain of S.
Jing ZHANG +4 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Itraconazole is a triazole antifungal agent with highly variable pharmacokinetics, with not yet fully identified factors as the source of this variability.
Milijana N. Miljković +14 more
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Structural basis for itraconazole-mediated NPC1 inhibition
Nature Communications, 2020 Niemann-Pick C1 (NPC1), a lysosomal protein of 13 transmembrane helices (TMs) and three lumenal domains, exports low-density-lipoprotein (LDL)-derived cholesterol from lysosomes. TMs 3–7 of NPC1 comprise the Sterol-Sensing Domain (SSD).
T. Long +5 more
semanticscholar +1 more source
Cell Death and Disease, 2020 Itraconazole is as an antifungal medication used to treat systemic fungal infections. Recently, it has been reported to be effective in suppressing tumor growth by inhibiting the Hedgehog signaling pathway and angiogenesis.
Huiming Deng +5 more
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Intravitreal itraconazole inhibits laser-induced choroidal neovascularization in rats. [PDF]
PLoS ONE, 2017 Choroidal neovascularization (CNV) is a major cause of severe visual loss in patients with age-related macular degeneration (AMD). Recently, itraconazole has shown potent and dose-dependent inhibition of tumor-associated angiogenesis.
Jeong Hun Bae +7 more
doaj +1 more source
Iranian Journal of Allergy, Asthma and Immunology, 2023 The purpose of this study was to evaluate the effect of 8 months of treatment with itraconazole on airway wall thickness in patients with severe persistent asthma.
Farnaz Aligolighasemabadi +6 more
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In vitro activity of itraconazole against SARS‐CoV‐2
bioRxiv, 2020 Background As long as there is no vaccine available, having access to inhibitors of SARS-CoV-2 will be of utmost importance. Antivirals against coronaviruses do not exist, hence global drug re-purposing efforts have been carried out to identify agents ...
E. Damme +10 more
semanticscholar +1 more source