Results 21 to 30 of about 56,596 (269)
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022 Understanding cancer biology and the development of novel agents for cancer treatment has always been the goal of cancer researchers. However, the research and development of new drugs is hindered by its long development time, exorbitant cost, high ...
Chun-Lan Li +5 more
semanticscholar +1 more source
Itraconazole Inhibits the Growth of Cutaneous Squamous Cell Carcinoma by Targeting HMGCS1/ACSL4 Axis
Frontiers in Pharmacology, 2022 Background: Cutaneous squamous cell carcinoma (cSCC) is a common cutaneous cancer with increasing incidence. Itraconazole has been identified as a potential anticancer drug candidate. However, the role of itraconazole in cSCC was still unclear.
Congcong Xu +3 more
doaj +1 more source
Open Forum Infectious Diseases, 2022 Background Itraconazole is first-line treatment for mild-moderate blastomycosis and consolidation of moderate-severe disease. Itraconazole is metabolized to 3 metabolites, including an active metabolite hydroxy-itraconazole.
Danielle Hess +7 more
semanticscholar +1 more source
Gender differences in concentration of itraconazole and hydroxyitraconazole [PDF]
Halo 194, 2021 Introduction: Itraconazole is an antifungal drug belonging to the triazole group. After oral application, it is rapidly absorbed, but its bioavailability is reduced due to an intensive first-pass through the liver metabolism effect.
Stanojković Tijana +4 more
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Frontiers in Veterinary Science, 2021 Candida krusei (C. krusei) has been recently recognized as an important pathogen involved in mycotic mastitis of cows. The phenotypic and molecular characteristics of 15 C.
Jun Du +11 more
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Cardiotoxicity with Itraconazole [PDF]
BMJ Case Reports, 2017 Itraconazole is a commonly used antifungal drug. In addition to commonly described adverse effects, there have been few reports of heart failure with its use. We present two cases that developed acute systolic heart failure with Itraconazole use. A man in his early 30s was admitted with worsening leg swelling and dyspnoea on exertion.
Vishesh, Paul, Harsh, Rawal
openaire +2 more sources
Overexpression of Both ERG11 and ABC2 Genes Might Be Responsible for Itraconazole Resistance in Clinical Isolates of Candida krusei. [PDF]
PLoS ONE, 2015 To study the main molecular mechanisms responsible for itraconazole resistance in clinical isolates of Candida krusei.The 14α-demethylases encoded by ERG11 gene in the 16 C.krusei clinical isolates were amplified by polymerase chain reaction (PCR), and ...
Xiaoyuan He +13 more
doaj +1 more source
Heliyon, 2023 Infantile hemangioma (IH) is among the most prevalent benign vascular tumours in infants. The pathogenesis of IH mainly involves abnormal proliferation of vascular endothelial cells and the formation of new vessels. Itraconazole was shown to be effective
Jianyong Dong +4 more
doaj +1 more source
Pifu-xingbing zhenliaoxue zazhi, 2020 Objective: To evaluate virulence of itraconazole-resistant Sporothrix globosa and its sensitivity to itraconazole in Galleria mellonella. Methods: Itraconazole-resistant strain and itraconazole-sensitive strain of S.
Jing ZHANG +4 more
doaj +1 more source
Molecular Cancer Therapeutics, 2021 Itraconazole, an FDA-approved antifungal, has antitumor activity against a variety of cancers. We sought to determine the effects of itraconazole on esophageal cancer and elucidate its mechanism of action.
Wei Zhang +23 more
semanticscholar +1 more source