Results 41 to 50 of about 37,692 (229)
Indian Journal of Dermatology, 2022 Background: An increasing number of dermatophytosis is seen now in daily clinical practice, with unusual presentations, running a chronic recurrent course and seems to be more resistant to systemic and topical conventional treatments, which necessitate ...
Dooha K Alhamdi, Khalil I Alhamdi
doaj +1 more source
, 2023 We describe a married couple who both presented with hypertension and hypokalaemia. Both patients were diagnosed with pseudohyperaldosteronism triggered by the widely used antifungal drug itraconazole.
Serup, Jørgen +3 more
core +1 more source
CYP3A5 genetic variability influences sildenafil and metabolite in pulmonary hypertension
British Journal of Clinical Pharmacology, EarlyView.Aim Interindividual variability in sildenafil response among pulmonary hypertension patients (PH) may be influenced by CYP3A5 polymorphisms. CYP3A5*3 allele reduces CYP3A5 activity and affects sildenafil metabolism. This study investigated the associations between CYP3A5 genotype and plasma concentrations of sildenafil and N‐desmethyl sildenafil, as ...
Pranisa Wongwien +7 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Clinical significance of acute kidney injury in idiosyncratic drug‐induced liver injury: a multicentric propensity scores matched study. Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug‐induced liver injury (DILI) is still scarce.
José María Pinazo‐Bandera +15 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Clinical pharmacology and pharmacometrics teams are now being encouraged to implement the ICH M15 framework in drug development to support model‐informed decisions in regulatory submissions. Although model performance is an important component of model evaluation, regulatory confidence also depends on the intended context of use (CoU) and the ...
Karen Rowland Yeo +6 more
wiley +1 more source
Antifungal Susceptibility Pattern of Non - Dermatophytic Fungi Causing Onychomycosis
Nepal Journal of Dermatology, Venereology & Leprology, 2020 Introduction: Non-dermatophytic molds (NDM) are filamentous fungi or yeast, commonly found in nature as saprophytes and plant pathogens. The incidence of onychomycosis due to NDM is 1.45 – 16.6%.
Apurva Kaushal +5 more
doaj +3 more sources
Frontiers in Oncology, 2020 Oral Squamous Cell Carcinoma (OSCC) presents an important challenge for the health systems worldwide. Thus, unraveling the biological mechanisms involved in OSCC pathogenesis is essential to the discovery of new drugs with anticancer potential.
Raíza Dias Freitas +20 more
doaj +1 more source
Cakradonya Dental Journal, 2019 Itraconazole merupakan salah satu obat sintetik yang memiliki keterbatasan dalam menghambat pertumbuhan Candida albicans (C. albicans). Kulit buah durian (Durio zibethinus L.) merupakan salah satu tanaman yang memiliki efek antifungal karena mengandung ...
Siti Rusdiana Puspa Dewi +2 more
doaj +1 more source
Indian Dermatology Online Journal, 2021 Itraconazole, is the most commonly prescribed oral antifungal agent in India, and has a low minimum inhibitory concentration as compared to other oral antifungals, and in conjunction with the markedly high skin levels, the drug should have a predictably ...
Kabir Sardana, Sinu Rose Mathachan
doaj +1 more source
Deep Dermatophytosis Associated With Inherited CARD9 Deficiency: Efficacy of Topical 1% Voriconazole
JEADV Clinical Practice, EarlyView.ABSTRACT Deep dermatophytosis (DD) is a rare, life‐threatening fungal infection associated with autosomal recessive CARD9 deficiency. Management remains challenging, as systemic antifungals often fail to achieve lasting control. A 54‐year‐old man with a 20‐year history of ulcerative skin lesions and confirmed CARD9 deficiency (Q289X/Q289X) presented ...
Sarah Milesi +6 more
wiley +1 more source