Results 31 to 40 of about 56,596 (269)
Frontiers in Pharmacology, 2022 Itraconazole is a triazole antifungal agent with highly variable pharmacokinetics, with not yet fully identified factors as the source of this variability.
Milijana N. Miljković +14 more
doaj +1 more source
Itraconazole exerts anti-liver cancer potential through the Wnt, PI3K/AKT/mTOR, and ROS pathways.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020 Hepatocellular carcinoma (HCC) is one of the most common cancers with the highest morbidity and mortality. It is necessary to develop new anti-liver cancer drugs.
Wen-Ping Wang +10 more
semanticscholar +1 more source
European Journal of Pharmaceutical Sciences, 2020 Considering the increased incidence of sporotrichosis and other fungal infections in rural and urban areas, and the limitations and adverse effects of oral itraconazole therapy, we studied nanostructured lipid carriers (NLC) as topical delivery systems ...
J. S. Passos +5 more
semanticscholar +1 more source
Significant elevation of free itraconazole concentration at onset of adverse effects: A case report
Clinical Case Reports, 2021 Free itraconazole and hydroxyitraconazole concentrations were markedly elevated despite almost no changes in total concentrations when itraconazole was discontinued due to adverse effects.
Ryota Tanaka +10 more
doaj +1 more source
Structural basis for itraconazole-mediated NPC1 inhibition
Nature Communications, 2020 Niemann-Pick C1 (NPC1), a lysosomal protein of 13 transmembrane helices (TMs) and three lumenal domains, exports low-density-lipoprotein (LDL)-derived cholesterol from lysosomes. TMs 3–7 of NPC1 comprise the Sterol-Sensing Domain (SSD).
T. Long +5 more
semanticscholar +1 more source
Intravitreal itraconazole inhibits laser-induced choroidal neovascularization in rats. [PDF]
PLoS ONE, 2017 Choroidal neovascularization (CNV) is a major cause of severe visual loss in patients with age-related macular degeneration (AMD). Recently, itraconazole has shown potent and dose-dependent inhibition of tumor-associated angiogenesis.
Jeong Hun Bae +7 more
doaj +1 more source
Solubilization of Itraconazole by Surfactants and Phospholipid-Surfactant Mixtures: Interplay of Amphiphile Structure, pH and Electrostatic Interactions [PDF]
, 2020 Although surfactants are frequently used in enabling formulations of poorly water-soluble drugs, the link between their structure and drug solubilization capacity is still unclear.
Nikola, Burdzhiev +3 more
core +2 more sources
Journal of Pharmaceutical Analysis, 2014 A highly sensitive, selective, and precise ultra-performance liquid chromatography tandem mass spectrometry method was developed and validated for simultaneous quantification of itraconazole and hydroxy itraconazole in human plasma by a single liquidâ ...
Ashish Dwivedi +4 more
doaj +1 more source
Cell Death and Disease, 2020 Itraconazole is as an antifungal medication used to treat systemic fungal infections. Recently, it has been reported to be effective in suppressing tumor growth by inhibiting the Hedgehog signaling pathway and angiogenesis.
Huiming Deng +5 more
semanticscholar +1 more source
Determination of itraconazole and hydroxyitraconazole in plasma by use of liquid chromatography-tandem mass spectrometry with on-line solid-phase extraction [PDF]
, 2003 In this paper a method for the simultaneous quantification of the anti-fungal drug itraconazole and its co-active metabolite hydroxyitraconazole in plasma employing liquid chromatography tandem-mass spectrometry and automated solid-phase extraction is ...
Spöhrer, Ute +2 more
core +1 more source