Results 51 to 60 of about 56,596 (269)

Evaluation of Itraconazole and in Combination in the Treatment of Resistant and Recurrent Tinea Corporis and Cruris (Comparative Study) [PDF]

Al-Azhar International Medical Journal
Background: One of the most prevalent dermatological disorders in the world is tinea infection. Itraconazole is still a crucial medication for treating and preventing fungal infections. Because of its wide range of action, terbinafine (TBF) is frequently
Mohammed Ewaiss, Mohamed El-khalawany, Hamed Abdo   +2 more
doaj   +1 more source

Concentration-dependent early anti-vascular and anti-tumor effects of itraconazole in non-small cell lung cancer

Clinical Cancer Research, 2020
Purpose: Itraconazole has been repurposed as an anticancer therapeutic agent for multiple malignancies. In preclinical models, itraconazole has antiangiogenic properties and inhibits Hedgehog pathway activity.
D. Gerber, W. Putnam, F. Fattah, K. Kernstine, R. Brekken, I. Pedrosa, R. Skelton, Jessica M. Saltarski, R. Lenkinski, R. Leff, C. Ahn, Chyndhri Padmanabhan, Vaidehi Chembukar, S. Kasiri, R. Kallem, Indhumathy Subramaniyan, Qing Yuan, Q. Do, Y. Xi, S. Reznik, L. Pelosof, B. Faubert, R. DeBerardinis, James Kim   +23 more
semanticscholar   +1 more source

Repurposing antifungals: population pharmacokinetics of itraconazole and hydroxy-itraconazole following administration of a nanocrystal formulation. [PDF]

, 2023
OBJECTIVES: To describe itraconazole and hydroxy-itraconazole pharmacokinetics following intravenous (IV) administration of a previously developed nanocrystal formulation (NCF) in haematopoietic cell transplant (HCT) recipients for prophylaxis of ...
Donnelly, J.P., Jansen, A.M.E., Heine, R. ter, Blijlevens, N.M.A., Bruggemann, R.J.M.   +4 more
core  

The Synergistic Effect of Tacrolimus (FK506) or Everolimus and Azoles Against Scedosporium and Lomentospora Species In Vivo and In Vitro

Frontiers in Cellular and Infection Microbiology, 2022
Scedosporium and Lomentospora infections in humans are generally chronic and stubborn. The use of azoles alone cannot usually inhibit the growth of these fungi.
Zikuo Wang, Mei Liu, Luyao Liu, Linyun Li, Lihua Tan, Yi Sun   +5 more
doaj   +1 more source

Combining derivative and synchronous approaches for simultaneous spectrofluorimetric determination of terbinafine and itraconazole [PDF]

Royal Society Open Science, 2020
In this study, determination of terbinafine and itraconazole down to biological concentration level has been carried out. The determination is based on increasing the selectivity of the spectrofluorimetric technique by combining both derivative and ...
Heba Elmansi, Aya Roshdy, Shereen Shalan, Amina El-Brashy   +3 more
doaj   +1 more source

Variability of Hydroxy-Itraconazole in Relation to Itraconazole Bloodstream Concentrations. [PDF]

, 2021
We analyzed the relationship between itraconazole (ITZ) and hydroxy-itraconazole (OH-ITZ) levels in 1,223 human samples. Overall, there was a statistically significant correlation between ITZ and OH-ITZ levels (Pearson's r, 0.7838), and OH-ITZ levels ...
Patterson, Thomas F, Schwartz, Ilan S, Wiederhold, Nathan P, Thompson, George R   +3 more
core   +1 more source

Effect of itraconazole on the quality of life in patients with moderate to severe seborrheic dermatitis: a randomized, placebo-controlled trial

Dermatology Practical & Conceptual, 2016
Background: Few studies have examined the effect of seborrheic dermatitis (SD) and/or its consequent therapy on a patient’s quality of life. Itraconazole has been suggested as an effective therapy for severe SD but its impact on Quality of Life (QoL) in ...
Zaheer Abbas, Seyede Zahra Ghodsi, Robabeh Abedeni   +2 more
doaj   +1 more source

Efficacy of oral terbinafine versus itraconazole in treatment of dermatophytic infection of skin – A prospective, randomized comparative study

Indian Journal of Pharmacology, 2019
OBJECTIVES: Dermatophytic infections are the common fungal infections aggravated by hot and humid climate. Terbinafine and itraconazole are commonly used oral antifungal agents for the same.
A. Bhatia, B. Kanish, D. Badyal, Prajakta Kate, Swati Choudhary   +4 more
semanticscholar   +1 more source

Effects of Cytochrome P450 Inhibitors on Itraconazole and Fluconazole Induced Cytotoxicity in Hepatocytes

Journal of Toxicology, 2009
Itraconazole and fluconazole have been reported to induce hepatotoxicity in patients. The present study was designed to investigate the role of cytochrome P450 inhibitors, SKF 525A, and curcumin pretreatment on the cytotoxicity of antifungal drugs ...
Nhareet Somchit, Chong Sock Ngee, Azhar Yaakob, Zuraini Ahmad, Zainul Amiruddin Zakaria   +4 more
doaj   +1 more source

Itraconazole in dermatology

Journal of Dermatological Treatment, 1992
Itraconazole is a triazole analogue with a broad spectrum of antifungal activity, which covers yeasts and moulds. It is active against dermatophytes, candidal and pityrosporum yeasts, as well as a number of fungi which cause subcutaneous and systemic infection. It is well absorbed and has significantly fewer side-effects than systemic imidazoles. It is
openaire   +2 more sources