Results 51 to 60 of about 37,692 (229)

Effect of itraconazole and fluconazole on the pharmacokinetics of valemetostat: An open‐label, phase I study in healthy subjects

Clinical and Translational Science, 2023
Valemetostat tosylate (valemetostat) is an oral, potent, dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1 under investigation for the treatment of cancer, including non‐Hodgkin's lymphomas and solid tumors.
Masaya Tachibana, Shunji Matsuki, Yutaro Maekawa, Kana Kuroda, Takako Shimizu, Junko Tsutsumi, Hitoshi Ishizuka   +6 more
doaj   +1 more source

The Efficacy and Safety of Miconazole Nitrate Mucoadhesive Tablets versus Itraconazole Capsules in the Treatment of Oral Candidiasis: An Open-Label, Randomized, Multicenter Trial. [PDF]

PLoS ONE, 2016
Oral candidiasis (OC) is a common oral fungal infection. Recently, miconazole mucoadhesive tablets have been gaining attention for OC treatment. Despite trials in patients with human immunodeficiency virus and cancer, evidence of its application in the ...
Zhimin Yan, Xiaosong Liu, Yang Liu, Ying Han, Mei Lin, Wenmei Wang, Xiaobing Guan, Shengrong Zhu, Handong Zhang, Qintao Wang, Lihong Chou, Xinghao Zhu, Hong Hua   +12 more
doaj   +1 more source

Efficacy of Endoscopic Sinus Surgery for Allergic Fungal Rhinosinusitis: A Systematic Review With Meta‐analysis

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Endoscopic sinus surgery (ESS) plays a central role in the management of allergic fungal rhinosinusitis (AFRS); however, outcomes vary across studies. The goal of this study is to systematically review and synthesize evidence on the outcomes of ESS in patients with AFRS.
Amani Kais, Jad Kfouri, Ahmad R. Sedaghat, Charles Alex Riley, Chadi A. Makary   +4 more
wiley   +1 more source

Aspartic Protease Inhibition Induces Proteomic Remodeling in Paracoccidioides brasiliensis

PROTEOMICS, EarlyView.
ABSTRACT Paracoccidioidomycosis (PCM) is a major systemic mycosis in Latin America caused by Paracoccidioides brasiliensis, yet the contribution of aspartic proteases to fungal physiology and pathogenicity remains poorly understood. Here, we employed data‐independent acquisition (DIA)‐based quantitative proteomics to investigate the impact of pepstatin
Sarah Fernandes Lima, Wilson Dias Segura, Leonardo Brogliato de Moraes, Reinaldo Souza Oliveira, Pedro Henrique Corteletti Manfio, Alison Felipe Alencar Chaves, Wagner Luiz Batista   +6 more
wiley   +1 more source

Itraconazole associated quadriparesis and edema: a case report

Journal of Medical Case Reports, 2011
Introduction Itraconazole is an anti-fungal agent widely used to treat various forms of mycosis. It is particularly useful in allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization. Side effects are uncommon and usually mild.
Denning David W, Kellett Mark, Gow David, Karadi Rangaprasad L, O'Driscoll Ronan B   +4 more
doaj   +1 more source

Paediatric Tinea Capitis in New Zealand: A Case Series

Australasian Journal of Dermatology, EarlyView.
ABSTRACT We reviewed 41 children referred to a New Zealand regional dermatology service between 2016 and 2026 with scalp alopecia suspected to be tinea capitis. Microsporum canis accounted for 17 of the 24 dermatophytes isolated (71%), a distribution consistent with New Zealand series over the past seven decades and unlike the shift towards ...
Karen Koch
wiley   +1 more source

Ocular and cutaneous infection due to Curvularia pseudobrachyspora in an immunosuppressed dog: Case report and in vitro antimycotic susceptibilities

Australian Veterinary Journal, EarlyView.
A 3‐year‐old male Border Collie diagnosed with immune‐mediated dermatopathy, managed with tapering prednisolone and cyclosporine, developed rapidly progressive ocular signs and additional cutaneous lesions. Histopathology, mycological culture, polymerase chain reaction and sequencing confirmed intraocular and cutaneous infection due to Curvularia ...
T Brasil‐Ervedosa, R Clark, J Granados‐Soler, C Palmieri, V Gonzalez‐Astudillo   +4 more
wiley   +1 more source

∆24-sterol methyltransferase plays an important role in the growth and development of Sporothrix schenckii and Sporothrix brasiliensis

Frontiers in Microbiology, 2016
Inhibition of ∆24-sterol methyltransferase (24-SMT) in Sporothrix schenckii sensu stricto and Sporothrix brasiliensis was investigated in vitro. The effects on fungal growth and sterol composition of the 24-SMT inhibitor 22-hydrazone-imidazolin-2-yl-chol-
Luana Pereira Borba-Santos, Gonzalo eVisbal, Gonzalo eVisbal, Thalita Gagini Braga, Anderson Messias Rodrigues, Zoilo Pires De Camargo, Leila Lopes Bezerra, Kelly eIshida, Wanderley eDe Souza, Sonia eRozental   +9 more
doaj   +1 more source

Emergence of Trichophyton indotineae in Switzerland (2014–2025): Clinical analysis and antifungal susceptibility

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Trichophyton indotineae is an emerging dermatophyte associated with chronic, recalcitrant dermatophytosis and terbinafine resistance due to squalene epoxidase (SQLE) mutations. We analyzed clinical characteristics, antifungal susceptibility profiles, SQLE mutations, and treatment outcomes of cases diagnosed in ...
Annabel H. Lechner, Dennis D. Arnold, Philipp P. Bosshard   +2 more
wiley   +1 more source

Treatment of sporotrichosis with itraconazole [PDF]

, 1993
To describe the clinical presentation and outcomes of treatment with itraconazole in patients with sporotrichosis. A culture for Sporothrix schenckii or compatible histopathology was required for inclusion in the study.
Stevens, David A., Graybill, John R., Kauffman, Carol A., Hostetler, John S., Cloud, Gretchen A., Sharkey-Mathis, Patricia Kay, Dismukes, William E.   +6 more
core   +1 more source