Results 51 to 60 of about 48,966 (221)

Comparison of Efficacy and Safety between Super-bioavailable Itraconazole and Conventional Itraconazole in the Treatment of Tinea Infection of Glabrous Skin – A Randomised Observer-blinded Pilot Study

Journal of Pure and Applied Microbiology, 2023
Itraconazole is now being used as the first line drug for dermatophytosis. Complete clinical and mycological cure are not achieved in some cases. The Super Bioavailable (SB) formulation is being marketed as a better formulation of drug in terms of ...
Liza Mohapatra, Nibedita Dixit, Ishan Agrawal, Bikash Ranjan Kar, Bhabani S.T.P. Singh   +4 more
doaj   +1 more source

Quantitative prediction of intravenous drug interactions caused by cytochromes P450 inhibitors and inducers

British Journal of Clinical Pharmacology, EarlyView.
Background Aims Pharmacokinetic interaction studies typically focus on oral administration, but intravenous (IV) administration bypasses intestinal degradation and hepatic first‐pass metabolism, leading to distinct drug–drug interaction (DDI) magnitude. This study aimed to develop a predictive model for DDIs involving IV‐administered drugs.
Vianney Tuloup, Michel Tod, Laurent Bourguignon   +2 more
wiley   +1 more source

In vitro and in vivo antimicrobial effects of domiphen combined with itraconazole against Aspergillus fumigatus

Frontiers in Microbiology, 2023
Aspergillus fumigatus, a prevalent saprophytic fungus in the atmosphere, is known to rapidly induce severe invasive aspergillosis (IA) upon inhalation of its conidia by humans or animals. The mortality rate associated with IA exceeds 50%.
Huan Yang, Huan Yang, Yufan Gu, Yufan Gu, Zhiqiang He, Zhiqiang He, Jia-Nan Wu, Jia-Nan Wu, Chen Wu, Chen Wu, Yuhan Xie, Yuhan Xie, Yuxin You, Yuxin You, Yijia Yang, Yijia Yang, Xinyu Zhou, Xinyu Zhou, Yi Liu, Yi Liu, Wenlong Du, Wenlong Du   +21 more
doaj   +1 more source

Population Pharmacokinetics of Ticagrelor during Veno‐Arterial ECMO in Acute Coronary Syndrome: Model‐Informed Dosing Simulations

Clinical Pharmacology &Therapeutics, EarlyView.
Although patients with acute coronary syndrome supported by veno‐arterial extracorporeal membrane oxygenation (VA‐ECMO) have a high risk of thrombosis and bleeding, antiplatelet pharmacology in this setting is not well defined. This prospective observational study investigated the population pharmacokinetics of ticagrelor and its active metabolite AR ...
Soyoung Kang, Kyoung Lok Min, Seungwon Yang, Jongsung Hahn, Dasohm Kim, Byung Hak Jin, Soon Uk Chae, Soo Kyung Bae, Jin Wi, Min Jung Chang   +9 more
wiley   +1 more source

The anti-cancer effects of itraconazole in epithelial ovarian cancer

Scientific Reports, 2017
We assessed the anti-proliferative activity of itraconazole using an EOC cell line (SKOV3ip1) and endothelial cell lines (HUVEC & SVEC4-10). We also examined angiogenesis (VEGFR2, p-ERK, p-PLCr1/2), hedgehog (Gli1, Ptch1, SMO), and mTOR (pS6K1) signaling
Chel Hun Choi, Ji-Yoon Ryu, Young-Jae Cho, Hye-Kyung Jeon, Jung-Joo Choi, Kris Ylaya, Yoo-Young Lee, Tae-Joong Kim, Joon-Yong Chung, Stephen M. Hewitt, Byoung-Gie Kim, Duk-Soo Bae, Jeong-Won Lee   +12 more
doaj   +1 more source

Itraconazole associated quadriparesis and edema: a case report

Journal of Medical Case Reports, 2011
Introduction Itraconazole is an anti-fungal agent widely used to treat various forms of mycosis. It is particularly useful in allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization. Side effects are uncommon and usually mild.
Denning David W, Kellett Mark, Gow David, Karadi Rangaprasad L, O'Driscoll Ronan B   +4 more
doaj   +1 more source

The Efficacy and Safety of Miconazole Nitrate Mucoadhesive Tablets versus Itraconazole Capsules in the Treatment of Oral Candidiasis: An Open-Label, Randomized, Multicenter Trial. [PDF]

PLoS ONE, 2016
Oral candidiasis (OC) is a common oral fungal infection. Recently, miconazole mucoadhesive tablets have been gaining attention for OC treatment. Despite trials in patients with human immunodeficiency virus and cancer, evidence of its application in the ...
Zhimin Yan, Xiaosong Liu, Yang Liu, Ying Han, Mei Lin, Wenmei Wang, Xiaobing Guan, Shengrong Zhu, Handong Zhang, Qintao Wang, Lihong Chou, Xinghao Zhu, Hong Hua   +12 more
doaj   +1 more source

Super bioavailable itraconazole and its place and relevance in recalcitrant dermatophytosis: Revisiting skin levels of itraconazole and minimum inhibitory concentration data

Indian Dermatology Online Journal, 2021
Itraconazole, is the most commonly prescribed oral antifungal agent in India, and has a low minimum inhibitory concentration as compared to other oral antifungals, and in conjunction with the markedly high skin levels, the drug should have a predictably ...
Kabir Sardana, Sinu Rose Mathachan
doaj   +1 more source

Is a Clinical Trial With a Non‐Bioequivalent Batch Necessary? The Critical Role of Intrasubject Variability in Olaparib Formulation Bridging by PBPK

Clinical Pharmacology &Therapeutics, EarlyView.
Although physiologically based pharmacokinetic (PBPK) modeling is increasingly being used to support oral drug formulation bridging, the acceptance by regulatory agencies is low. One of the primary concerns is the absence of clinical pharmacokinetic (PK) data from a non‐bioequivalent (non‐BE) batch during model validation.
Jin Dong, Andrea Moir, Xavier Pepin, Elizabeth Lowe, Sandy Hopkins, Weifeng Tang, Diansong Zhou   +6 more
wiley   +1 more source

Voriconazole treatment of Candida tropicalis meningitis: persistence of (1,3)-b-D-glucan in the cerebrospinal fluid is a marker of clinical and microbiological failure [PDF]

, 2016
Introduction: Infections are still the most common complications of cerebral shunt procedures. Even though fungal etiologies are considered to be rare, they are associated with significant morbidity and mortality.
Brunetti, Grazia, Ceccarelli, Giancarlo, Fallani, Stefania, Ghezzi, Maria Cristina, Marsiglia, Carolina, Novelli, Andrea, Raponi, Giammarco, Venditti, Mario   +7 more
core   +2 more sources