Results 61 to 70 of about 37,692 (229)

Pancreatitis associated with the use of itraconazole

, 2010
BACKGROUND: We call attention to the assumed association between itraconazole and pancreatitis by presentation of four Dutch case reports.METHODS AND RESULTS: The Netherlands Pharmacovigilance Centre Lareb received four reports of pancreatitis associated
van Puijenbroek, E P; id_orcid, van Grootheest, A C, Passier, J L M, Jonkers, G J P M   +3 more
core   +2 more sources

Onychogryposis Secondary to Underlying Phalangeal Non‐Union

JEADV Clinical Practice, EarlyView.
Sunil Jaiswal, Shraddha Uprety, Pratichya Thapa, Smarika Upadhyaya, Aditi Joshi, Prakriti Lamichhane   +5 more
wiley   +1 more source

An Unusual Case Report of Iatrogenic Metrorrhagia and Hematochezia Following Itraconazole

Clinical Dermatology Review
Itraconazole is an effective triazole antimycotic drug that has a desirable pharmacokinetic profile to combat various fungal pathogens. It acts by inhibiting ergosterol biosynthesis in fungal cell membranes.
Yashaswi Rai
doaj   +1 more source

A Verrucous Plaque After Traumatic Inoculation

JEADV Clinical Practice, EarlyView.
Juan Felipe Ochoa‐Bermudez, Paula Andrea Hernández‐Arias, Maria Valentina Oliver‐Hernández, Samuel Morales, ÁlvaroTovar Cock   +4 more
wiley   +1 more source

Eosinophilia and Hypereosinophilia: A Practical Approach to Navigating a Broad Differential Diagnosis

European Journal of Haematology, EarlyView.
ABSTRACT Eosinophilia, defined as an absolute eosinophil count (AEC) of ≥ 0.5 × 109/L, is a frequently encountered finding with a vast spectrum of potential underlying etiologies. Hypereosinophilia (HE) is defined as AEC > 1.5 × 109/L and may become life‐threatening when eosinophil‐induced organ damage occurs, defining the hypereosinophilic syndrome ...
Stijn Wigerinck, Peter Vandenberghe
wiley   +1 more source

Population pharmacokinetics of itraconazole and its active metabolite hydroxy-itraconazole in paediatric cystic fibrosis and bone marrow transplant patients

, 2006
Objective: The objective of the study was to characterise the population pharmacokinetic properties of itraconazole and its active metabolite hydroxyitraconazole in a representative paediatric population of cystic fibrosis and bone marrow transplant (BMT)
Wainwright, C. E., Charles, B. G., Bell, S. C., Hennig, S., Friberg, L. E., Miller, H., Bell, Scott C., Miller, Hugh, Charles, Bruce G., Wainwright, Claire E., Hennig, Stefanie, Friberg, Lena E.,   +11 more
core   +1 more source

Mitochondrial iron homeostasis is required for azole tolerance in Candida albicans

The FEBS Journal, EarlyView.
In Candida albicans, the deletion of MRS4, which encodes a mitochondrial iron importer, abolishes fluconazole tolerance and increases cidality during cotreatment with the iron chelator BPS, without altering MIC or synergy. Fluconazole‐treated mutants exhibit increased mitochondrial depolarisation, fragmentation and reduced mitochondrial density.
Wouter Van Genechten, Gauthier Cornips, Martine De Jonge, Rudy Vergauwen, Patrick Van Dijck   +4 more
wiley   +1 more source

A Novel Approach to Reducing Chemoresistance in Advanced Ovarian Cancer: The Effect of Itraconazole—A Single-Institution Randomized Placebo-Controlled Trial

Current Oncology
Background: The five-year survival rate of patients with ovarian cancer remains less than 50%, secondary to chemotherapy resistance. Purpose: This study aims to evaluate the effects of itraconazole as a supplementary treatment with paclitaxel and ...
Ahmed E. S. Besheir, Sahar M. El-Hagar, Hesham A. Tawfik, Tarek M. Mostafa   +3 more
doaj   +1 more source

Treatment of systemic fungal infections with Itraconazole preparations

, 2006
イトラコナゾールは，non-albicans Candidaを含めたカンジダ属やアスペルギルス属に対しても強い抗真菌活性を示すトリアゾール系抗真菌薬である。日本ではカプセル薬のみしか市販されていないが，hydroxypropyl-β-cyclodextrin（HP-β-CD）に可溶化させることで内用液と注射薬がようやく日本でも開発された。内用液はカプセル薬に比べ消化管からの吸収性が改善され，注射薬は2日間のLoading dose（400 mg分2/日）により ...
河野, 茂
core  

Feasibility and clinical outcomes of routine point‐of‐care screening for opportunistic infections among people with advanced HIV disease in Guyana

HIV Medicine, EarlyView.
Abstract Objectives We evaluated the feasibility and outcomes of implementing comprehensive Point‐of‐care (POC) opportunistic infections (OIs) screening among people with Advanced HIV disease (AHD) in Guyana. Methods We conducted a prospective multicentre cohort study across seven sites between February 2024 and March 2025.
Antonio Camiro‐Zúñiga, Tariq Jagnarine, Divya Shivdas, Lakshmi Narain, Kwesi Vanccoten, Kampta Prashad, Abiola Jacobs, Quacy Grant, Mallika Mootoo, Narissa Lawerence, Suzanne Siebs, Escalada Rainier, Omar Sued, Freddy Perez   +13 more
wiley   +1 more source