Results 11 to 20 of about 26,822 (186)

Intravitreal itraconazole inhibits laser-induced choroidal neovascularization in rats. [PDF]

PLoS ONE, 2017
Choroidal neovascularization (CNV) is a major cause of severe visual loss in patients with age-related macular degeneration (AMD). Recently, itraconazole has shown potent and dose-dependent inhibition of tumor-associated angiogenesis.
Jeong Hun Bae, Ah Reum Hwang, Chan Yun Kim, Hyeong Gon Yu, Hyoung Jun Koh, Woo Ick Yang, Hae Ran Chang, Sung Chul Lee   +7 more
doaj   +1 more source

Ultra-performance liquid chromatography electrospray ionization–tandem mass spectrometry method for the simultaneous determination of itraconazole and hydroxy itraconazole in human plasma

Journal of Pharmaceutical Analysis, 2014
A highly sensitive, selective, and precise ultra-performance liquid chromatography tandem mass spectrometry method was developed and validated for simultaneous quantification of itraconazole and hydroxy itraconazole in human plasma by a single liquidâ ...
Ashish Dwivedi, Bhupinder Singh, Sandeep Sharma, R.S. Lokhandae, Naveen Dubey   +4 more
doaj   +1 more source

Itraconazole Improved Bronchial Wall Thickness in Severe Persistent Asthma: A Double-blind Placebo-controlled Randomized Clinical Trial

Iranian Journal of Allergy, Asthma and Immunology, 2023
The purpose of this study was to evaluate the effect of 8 months of treatment with itraconazole on airway wall thickness in patients with severe persistent asthma.
Farnaz Aligolighasemabadi, Majid Mirsadraee, Mohammadamin Sadeghdoust, Shadi Ghaffari, Mohammad Sarafraz Yazdi, Saeed Naghibi, Amirhossein Hashemi Attar   +6 more
doaj   +1 more source

Itraconazole Increases Ibrutinib Exposure 10‐Fold and Reduces Interindividual Variation—A Potentially Beneficial Drug‐Drug Interaction

Clinical and Translational Science, 2020
The oral bioavailability of ibrutinib is low and variable, mainly due to extensive first‐pass metabolism by cytochrome P450 (CYP) 3A4. The unpredictable exposure can compromise its safe and effective dosing.
Tuija Tapaninen, Aleksi M. Olkkola, Aleksi Tornio, Mikko Neuvonen, Erkki Elonen, Pertti J. Neuvonen, Mikko Niemi, Janne T. Backman   +7 more
doaj   +1 more source

Effect of itraconazole on the cornea in a murine suture model and penetrating keratoplasty model [PDF]

International Journal of Ophthalmology, 2017
AIM: To investigate the anti-(lymph)angiogenic and/or anti-inflammatory effect of itraconazole in a corneal suture model and penetrating keratoplasty (PK) model.
Yang Kyung Cho, Eun Young Shin, Hironori Uehara, Balamurali Ambati   +3 more
doaj   +1 more source

Tolerability of oral itraconazole and voriconazole for the treatment of chronic pulmonary aspergillosis: A systematic review and meta-analysis.

PLoS ONE, 2020
BackgroundChronic pulmonary aspergillosis (CPA) requires prolonged treatment with itraconazole or voriconazole. However, adverse events (AEs) are common with the use of these agents, with the need to discontinue the offending drug in a significant ...
Ronald Olum, Joseph Baruch Baluku, Andrew Kazibwe, Laura Russell, Felix Bongomin   +4 more
doaj   +1 more source

Itraconazole induces apoptosis and cell cycle arrest via inhibiting Hedgehog signaling in gastric cancer cells

Journal of Experimental & Clinical Cancer Research, 2017
Background Itraconazole has been proved therapeutically effective against a variety of human cancers. This study assessed the effect of itraconazole on the Hedgehog (Hh) pathway and proliferation of human gastric cancer cells.
Qiang Hu, Yi-Chao Hou, Jiao Huang, Jing-Yuan Fang, Hua Xiong   +4 more
doaj   +1 more source

Itraconazole-Induced Increases in Gilteritinib Exposure Are Mediated by CYP3A and OATP1B

Molecules, 2022
Gilteritinib, an FDA-approved tyrosine kinase inhibitor approved for the treatment of relapsed/refractory FLT3-mutated acute myeloid leukemia, is primarily eliminated via CYP3A4-mediated metabolism, a pathway that is sensitive to the co-administration of
Dominique A. Garrison, Yan Jin, Zahra Talebi, Shuiying Hu, Alex Sparreboom, Sharyn D. Baker, Eric D. Eisenmann   +6 more
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

The Synergistic Effect of Tacrolimus (FK506) or Everolimus and Azoles Against Scedosporium and Lomentospora Species In Vivo and In Vitro

Frontiers in Cellular and Infection Microbiology, 2022
Scedosporium and Lomentospora infections in humans are generally chronic and stubborn. The use of azoles alone cannot usually inhibit the growth of these fungi.
Zikuo Wang, Mei Liu, Luyao Liu, Linyun Li, Lihua Tan, Yi Sun   +5 more
doaj   +1 more source