Results 11 to 20 of about 56,596 (269)
Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trial
EBioMedicine, 2021 Background: The antifungal drug itraconazole exerts in vitro activity against SARS-CoV-2 in Vero and human Caco-2 cells. Preclinical and clinical studies are required to investigate if itraconazole is effective for the treatment and/or prevention of ...
Winston Chiu, Laurens Liesenborghs
exaly +4 more sources
Itraconazole induced ferroptosis in acute myeloid leukemia cells through TP53INP1 [PDF]
Frontiers in Molecular BiosciencesBackgroundItraconazole (ITRA) is a broad-spectrum antifungal agent approved by the Food and Drug Administration (FDA). It has been shown to inhibit cancer growth, but the underlying molecular mechanism of itraconazole-induced cell death in acute myeloid ...
Yan Qi +16 more
doaj +2 more sources
Clinical and Translational Science, 2020 The oral bioavailability of ibrutinib is low and variable, mainly due to extensive first‐pass metabolism by cytochrome P450 (CYP) 3A4. The unpredictable exposure can compromise its safe and effective dosing.
Tuija Tapaninen +7 more
doaj +2 more sources
Indian Dermatology Online Journal, 2021 Itraconazole, is the most commonly prescribed oral antifungal agent in India, and has a low minimum inhibitory concentration as compared to other oral antifungals, and in conjunction with the markedly high skin levels, the drug should have a predictably ...
Kabir Sardana, Sinu Rose Mathachan
doaj +2 more sources
Comparison of Efficacy and Safety between Super-bioavailable Itraconazole and Conventional Itraconazole in the Treatment of Tinea Infection of Glabrous Skin – A Randomised Observer-blinded Pilot Study [PDF]
Journal of Pure and Applied Microbiology, 2023 Itraconazole is now being used as the first line drug for dermatophytosis. Complete clinical and mycological cure are not achieved in some cases. The Super Bioavailable (SB) formulation is being marketed as a better formulation of drug in terms of ...
Liza Mohapatra +4 more
doaj +2 more sources
Journal of Experimental & Clinical Cancer Research, 2017 Background Itraconazole has been proved therapeutically effective against a variety of human cancers. This study assessed the effect of itraconazole on the Hedgehog (Hh) pathway and proliferation of human gastric cancer cells.
Qiang Hu +4 more
doaj +2 more sources
The anti-cancer effects of itraconazole in epithelial ovarian cancer
Scientific Reports, 2017 We assessed the anti-proliferative activity of itraconazole using an EOC cell line (SKOV3ip1) and endothelial cell lines (HUVEC & SVEC4-10). We also examined angiogenesis (VEGFR2, p-ERK, p-PLCr1/2), hedgehog (Gli1, Ptch1, SMO), and mTOR (pS6K1) signaling
Chel Hun Choi +12 more
doaj +2 more sources
Physiologically Based Pharmacokinetic Modeling to Assess Transporter-Mediated Drug-Drug Interactions in Support of Labeling Recommendations for Zavegepant Nasal Spray. [PDF]
Clin Pharmacol TherZavegepant nasal spray, a calcitonin gene‐related peptide receptor antagonist indicated for acute treatment of migraine with or without aura in adults, is a substrate for organic anion transporting polypeptide 1B3 (OATP1B3), Na+/taurocholate cotransporting polypeptide (NTCP), P‐glycoprotein (P‐gp), and cytochrome P450 3A4 (CYP3A4).
Ke A +8 more
europepmc +2 more sources
Itraconazole resistance in Aspergillus fumigatus
, 1997 Invasive aspergillosis is an increasingly frequent opportunistic infection in immunocompromised patients. Only two agents, amphotericin B and itraconazole, are licensed for therapy.
Manning, N. J. +7 more
core +10 more sources