Journal of Pharmaceutical Analysis, 2014 A highly sensitive, selective, and precise ultra-performance liquid chromatography tandem mass spectrometry method was developed and validated for simultaneous quantification of itraconazole and hydroxy itraconazole in human plasma by a single liquidâ ...
Ashish Dwivedi +4 more
doaj +2 more sources
Comparison of Efficacy and Safety between Super-bioavailable Itraconazole and Conventional Itraconazole in the Treatment of Tinea Infection of Glabrous Skin – A Randomised Observer-blinded Pilot Study [PDF]
Journal of Pure and Applied Microbiology, 2023 Itraconazole is now being used as the first line drug for dermatophytosis. Complete clinical and mycological cure are not achieved in some cases. The Super Bioavailable (SB) formulation is being marketed as a better formulation of drug in terms of ...
Liza Mohapatra +4 more
doaj +2 more sources
The anti-cancer effects of itraconazole in epithelial ovarian cancer
Scientific Reports, 2017 We assessed the anti-proliferative activity of itraconazole using an EOC cell line (SKOV3ip1) and endothelial cell lines (HUVEC & SVEC4-10). We also examined angiogenesis (VEGFR2, p-ERK, p-PLCr1/2), hedgehog (Gli1, Ptch1, SMO), and mTOR (pS6K1) signaling
Chel Hun Choi +12 more
doaj +2 more sources
Medical Mycology Case ReportsChronic cavitary pulmonary histoplasmosis requires prolonged treatment with itraconazole. However, hypersensitivity reactions to itraconazole, though rare, pose a challenge due to limited data on the efficacy and cross-reactivity of the newer azoles.
Miguel E. Cervera-Hernandez +1 more
doaj +2 more sources
Physiologically Based Pharmacokinetic Modeling to Assess Transporter-Mediated Drug-Drug Interactions in Support of Labeling Recommendations for Zavegepant Nasal Spray. [PDF]
Clin Pharmacol TherZavegepant nasal spray, a calcitonin gene‐related peptide receptor antagonist indicated for acute treatment of migraine with or without aura in adults, is a substrate for organic anion transporting polypeptide 1B3 (OATP1B3), Na+/taurocholate cotransporting polypeptide (NTCP), P‐glycoprotein (P‐gp), and cytochrome P450 3A4 (CYP3A4).
Ke A +8 more
europepmc +2 more sources
Itraconazole resistance in Aspergillus fumigatus
, 1997 Invasive aspergillosis is an increasingly frequent opportunistic infection in immunocompromised patients. Only two agents, amphotericin B and itraconazole, are licensed for therapy.
Manning, N. J. +7 more
core +5 more sources
Manuka Honey Sinus Irrigation Versus Systemic Itraconazole in Allergic Fungal Rhinosinusitis: Randomised Clinical Trial for Efficacy and Safety. [PDF]
Clin OtolaryngolABSTRACT Background Allergic fungal rhinosinusitis (AFRS) is a persistent sinus condition caused by fungal allergies. Endoscopic sinus surgery (ESS) and postoperative systematic and local medical therapies are the most common treatment protocols. Although oral antifungals such as itraconazole are frequently utilised postoperatively, there is increasing
Hamead K +4 more
europepmc +2 more sources
Significant elevation of free itraconazole concentration at onset of adverse effects: A case report
Clinical Case Reports, 2021 Free itraconazole and hydroxyitraconazole concentrations were markedly elevated despite almost no changes in total concentrations when itraconazole was discontinued due to adverse effects.
Ryota Tanaka +10 more
doaj +1 more source
, 2023 Plasma concentrations of itraconazole and hydroxy-itraconazole following oral administration of 200 mg itraconazole once daily or reference itraconazole (PK analysis set).
M. Bhrushundi (14614849) +11 more
core +1 more source
Variability of Hydroxy-Itraconazole in Relation to Itraconazole Bloodstream Concentrations. [PDF]
, 2021 We analyzed the relationship between itraconazole (ITZ) and hydroxy-itraconazole (OH-ITZ) levels in 1,223 human samples. Overall, there was a statistically significant correlation between ITZ and OH-ITZ levels (Pearson's r, 0.7838), and OH-ITZ levels ...
Patterson, Thomas F +7 more
core +1 more source