Results 21 to 30 of about 47,734 (283)
Intravitreal itraconazole inhibits laser-induced choroidal neovascularization in rats. [PDF]
PLoS ONE, 2017 Choroidal neovascularization (CNV) is a major cause of severe visual loss in patients with age-related macular degeneration (AMD). Recently, itraconazole has shown potent and dose-dependent inhibition of tumor-associated angiogenesis.
Jeong Hun Bae +7 more
doaj +1 more source
In vitro activity of itraconazole against SARS‐CoV‐2
bioRxiv, 2020 Background As long as there is no vaccine available, having access to inhibitors of SARS-CoV-2 will be of utmost importance. Antivirals against coronaviruses do not exist, hence global drug re-purposing efforts have been carried out to identify agents ...
E. Damme +10 more
semanticscholar +1 more source
Significant elevation of free itraconazole concentration at onset of adverse effects: A case report
Clinical Case Reports, 2021 Free itraconazole and hydroxyitraconazole concentrations were markedly elevated despite almost no changes in total concentrations when itraconazole was discontinued due to adverse effects.
Ryota Tanaka +10 more
doaj +1 more source
Iranian Journal of Allergy, Asthma and Immunology, 2023 The purpose of this study was to evaluate the effect of 8 months of treatment with itraconazole on airway wall thickness in patients with severe persistent asthma.
Farnaz Aligolighasemabadi +6 more
doaj +1 more source
The place for itraconazole in treatment [PDF]
Journal of Antimicrobial Chemotherapy, 2005 The incidence of systemic fungal infections has risen sharply in the last two decades, reflecting a rise in the number of patients who are predisposed to these diseases because they are immunosuppressed or immunocompromised. The growing use of intensive chemotherapy to treat cancer, highly immunosuppressive drug regimens (not only in transplant ...
Johan Maertens, Marc Boogaerts
openaire +3 more sources
Journal of Pharmaceutical Analysis, 2014 A highly sensitive, selective, and precise ultra-performance liquid chromatography tandem mass spectrometry method was developed and validated for simultaneous quantification of itraconazole and hydroxy itraconazole in human plasma by a single liquidâ ...
Ashish Dwivedi +4 more
doaj +1 more source
Effect of itraconazole on the cornea in a murine suture model and penetrating keratoplasty model [PDF]
International Journal of Ophthalmology, 2017 AIM: To investigate the anti-(lymph)angiogenic and/or anti-inflammatory effect of itraconazole in a corneal suture model and penetrating keratoplasty (PK) model.
Yang Kyung Cho +3 more
doaj +1 more source
PLoS ONE, 2020 BackgroundChronic pulmonary aspergillosis (CPA) requires prolonged treatment with itraconazole or voriconazole. However, adverse events (AEs) are common with the use of these agents, with the need to discontinue the offending drug in a significant ...
Ronald Olum +4 more
doaj +1 more source
Itraconazole-Induced Increases in Gilteritinib Exposure Are Mediated by CYP3A and OATP1B
Molecules, 2022 Gilteritinib, an FDA-approved tyrosine kinase inhibitor approved for the treatment of relapsed/refractory FLT3-mutated acute myeloid leukemia, is primarily eliminated via CYP3A4-mediated metabolism, a pathway that is sensitive to the co-administration of
Dominique A. Garrison +6 more
doaj +1 more source
Clinical Cancer Research, 2020 Purpose: Itraconazole has been repurposed as an anticancer therapeutic agent for multiple malignancies. In preclinical models, itraconazole has antiangiogenic properties and inhibits Hedgehog pathway activity.
D. Gerber +23 more
semanticscholar +1 more source