Results 61 to 70 of about 46,843 (269)

The Rare Presentation of Deep Dermatophytosis‐Trichophyton in an Immunosuppressed Patient

JEADV Clinical Practice, EarlyView.
ABSTRACT Dermatophytes typically cause superficial skin infections characterized by an active border. However, they can present atypically invading deeper in immunocompromised patients. We present a case of a 72‐year‐old woman with bullous pemphigoid who had received oral prednisolone for 3 months and developed umbilicated papules.
Jidapa Triwatcharikorn, Nitina Yeesibsean, Jirapon Jesrichai, Chanat Kumtornrut   +3 more
wiley   +1 more source

Ultra-performance liquid chromatography electrospray ionization–tandem mass spectrometry method for the simultaneous determination of itraconazole and hydroxy itraconazole in human plasma

Journal of Pharmaceutical Analysis, 2014
A highly sensitive, selective, and precise ultra-performance liquid chromatography tandem mass spectrometry method was developed and validated for simultaneous quantification of itraconazole and hydroxy itraconazole in human plasma by a single liquidâ ...
Ashish Dwivedi, Bhupinder Singh, Sandeep Sharma, R.S. Lokhandae, Naveen Dubey   +4 more
doaj  

∆24-sterol methyltransferase plays an important role in the growth and development of Sporothrix schenckii and Sporothrix brasiliensis

Frontiers in Microbiology, 2016
Inhibition of ∆24-sterol methyltransferase (24-SMT) in Sporothrix schenckii sensu stricto and Sporothrix brasiliensis was investigated in vitro. The effects on fungal growth and sterol composition of the 24-SMT inhibitor 22-hydrazone-imidazolin-2-yl-chol-
Luana Pereira Borba-Santos, Gonzalo eVisbal, Gonzalo eVisbal, Thalita Gagini Braga, Anderson Messias Rodrigues, Zoilo Pires De Camargo, Leila Lopes Bezerra, Kelly eIshida, Wanderley eDe Souza, Sonia eRozental   +9 more
doaj   +1 more source

Dermatophytic infection and in vitro activities of antifungal drugs against dermatophytes in rural India

Microbiologia Medica, 2021
Background Increase in resistance to conventional antifungals renders the need for antifungal sensitivity testing in Dermatophytes.   The present study aimed at determining the prevalence of dermatophytic infections and their susceptibility ...
Dharmendra Singh, Ankita Sharma, Rajesh Verma, Sweta Kumar, Satender Saraswat   +4 more
doaj   +1 more source

Repurposing itraconazole as an anticancer agent.

Oncology Letters, 2017
Itraconazole, a common anti-fungal agent, has demonstrated potential anticancer activity, including reversing chemoresistance mediated by P-glycoprotein, modulating the signal transduction pathways of Hedgehog, mechanistic target of rapamycin and Wnt/β ...
H. Tsubamoto, T. Ueda, Kayo Inoue, K. Sakata, H. Shibahara, T. Sonoda   +5 more
semanticscholar   +1 more source

Study on pharmacokinetic interactions between SHR2554 and itraconazole in healthy subjects: A single‐center, open‐label phase I trial

Cancer Medicine, 2023
Background SHR2554, a novel oral Enhancer of Zeste Homolog 2 inhibitor, shows broad‐spectrum anti‐tumor efficacy in preclinical studies. As SHR2554 is mainly metabolized by CYP3A4, it is helpful to conduct research on the effects of itraconazole, a ...
Kunhong Deng, Yi Zou, Chan Zou, Hong Wang, Yuxia Xiang, Xiaoyan Yang, Shuang Yang, Chang Cui, Guoping Yang, Jie Huang   +9 more
doaj   +1 more source

Subcutaneous basidiobolomycosis treated successfully with oral itraconazole: A case report

Indian Dermatology Online Journal, 2022
Basidiobolomycosis is an opportunistic fungal infection with a high morbidity and mortality rate. It is known to cause invasive disease in immunocompromised persons but it may produce only cutaneous or subcutaneous infections in an immunocompetent ...
Dixit G Chaudhari, Ashish Jagati, Raju G Chaudhary, Malhar J Shah   +3 more
doaj   +1 more source

Population Pharmacokinetic Modeling of the Oral Calcitonin Gene‐Related Peptide Receptor Antagonist Rimegepant in Adults

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Rimegepant is a small‐molecule calcitonin gene‐related peptide receptor antagonist approved for acute and preventive migraine treatment in adults, administered as an orally disintegrating tablet (ODT). A population pharmacokinetic analysis was performed to describe rimegepant's plasma concentration‐time course and to estimate covariate effects
Craig M. Comisar, Jim H. Hughes, Jose Francis, Yorinao Chinda, Yamato Sano, Chieko Muto, Christine Neumar, Rajinder Bhardwaj, Richard Bertz, Jing Liu   +9 more
wiley   +1 more source

Effects of Food and Omeprazole on a Novel Formulation of Super Bioavailability Itraconazole in Healthy Subjects

Antimicrobial Agents and Chemotherapy, 2018
To address the limited bioavailability and intolerance of the conventional itraconazole (ITZ) formulations, a new formulation labeled super bioavailability (SUBA) itraconazole has been developed; however, the specific effects of food and gastric pH are ...
Julian Lindsay, Stuart Mudge, G. Thompson   +2 more
semanticscholar   +1 more source

Isavuconazole and Calcium Channel Blocker for Invasive Fungal Disease Accompanied With Hypertension: Evidence From the FAERS and PBPK/PD Model

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
Safety assessment of ISA in combination with CCBs. Disproportionality analysis through the FAERS database showed that ISA was not associated with drug‐induced hypertension and DDI‐caused hypotension, whereas CCBs (nifedipine and amlodipine) were the most common co‐medications for hypotension occurring in combination with TADs.
Jianxing Zhou, Bo Xiao, Zipeng Wei, Mengting Jia, Xin Luo, Huimin Wei, Xiaohan Zhang, Maobai Liu, Yifan Zhang, Xuemei Wu   +9 more
wiley   +1 more source