Results 61 to 70 of about 47,734 (283)

Plinia cauliflora Leaf Extract Promotes Wound Healing Through Anti‐Inflammatory, Antioxidant, and Antibacterial Actions

Chemistry &Biodiversity, EarlyView.
ABSTRACT Plinia cauliflora (DC.) Kausel (jabuticaba) is traditionally used by Brazilian indigenous communities for therapeutic purposes, including the treatment of wounds and inflammation. This study investigated the phytochemical composition and biological activities of an ethanolic extract derived from P.
Priscila de Lima Paula, Mariana Hauck Vianna, Júlia Bertolini Fajardo, Ana Barbara Polo, Lara Melo Campos, Thayná Gomes Ferreira, Ari Sérgio de Oliveira Lemos, Thalita de Freitas Souza, Lívia Rodrigues Gamarano, Maria Clara Machado Resende Guedes, Samira Aparecida Coelho Souza, Ayrton Senna Pinheiro, Leandro De Santis Ferreira, José Maria Barbosa‐Filho, Elaine Soares Coimbra, Gilson Costa Macedo, Luciana Moreira Chedier, Rodrigo Luiz Fabri   +17 more
wiley   +1 more source

In vitro and in vivo antimicrobial effects of domiphen combined with itraconazole against Aspergillus fumigatus

Frontiers in Microbiology, 2023
Aspergillus fumigatus, a prevalent saprophytic fungus in the atmosphere, is known to rapidly induce severe invasive aspergillosis (IA) upon inhalation of its conidia by humans or animals. The mortality rate associated with IA exceeds 50%.
Huan Yang, Huan Yang, Yufan Gu, Yufan Gu, Zhiqiang He, Zhiqiang He, Jia-Nan Wu, Jia-Nan Wu, Chen Wu, Chen Wu, Yuhan Xie, Yuhan Xie, Yuxin You, Yuxin You, Yijia Yang, Yijia Yang, Xinyu Zhou, Xinyu Zhou, Yi Liu, Yi Liu, Wenlong Du, Wenlong Du   +21 more
doaj   +1 more source

A Review on Potentially Probiotic Yeasts From Traditional Fermented Products in Sub‐Saharan Africa for Sustainable Food Systems and Improved Health

Food Safety and Health, EarlyView.
This review focuses on the potential of sub‐Saharan African fermented food products as sources of probiotic yeasts for improved food security and health. ABSTRACT Research on probiotic yeasts from fermented products in sub‐Saharan Africa was limited in the past, but there is currently a surge in investigative efforts in this field.
Lethiwe Lynett Mbuyane
wiley   +1 more source

Exposure–Response Modeling and Simulation to Identify Optimal Mavacamten Posology When Coadministered with CYP3A4 and CYP2C19 Inhibitors in Patients with Obstructive HCM

The Journal of Clinical Pharmacology, EarlyView.
Abstract Mavacamten, a cardiac myosin inhibitor, is primarily metabolized by the cytochrome P450 (CYP) enzymes CYP2C19 and CYP3A4, and coadministration with strong CYP3A4 or CYP2C19 inhibitors was contraindicated in patients with obstructive hypertrophic cardiomyopathy (HCM) in the US Prescribing Information. This study assessed the safety and efficacy
Samira Merali, Haden Bunn, Caroline Sychterz, Manting Chiang, Shilpa Puli, Amy J. Sehnert, Bindu Murthy, Joga Gobburu   +7 more
wiley   +1 more source

∆24-sterol methyltransferase plays an important role in the growth and development of Sporothrix schenckii and Sporothrix brasiliensis

Frontiers in Microbiology, 2016
Inhibition of ∆24-sterol methyltransferase (24-SMT) in Sporothrix schenckii sensu stricto and Sporothrix brasiliensis was investigated in vitro. The effects on fungal growth and sterol composition of the 24-SMT inhibitor 22-hydrazone-imidazolin-2-yl-chol-
Luana Pereira Borba-Santos, Gonzalo eVisbal, Gonzalo eVisbal, Thalita Gagini Braga, Anderson Messias Rodrigues, Zoilo Pires De Camargo, Leila Lopes Bezerra, Kelly eIshida, Wanderley eDe Souza, Sonia eRozental   +9 more
doaj   +1 more source

The Efficacy and Safety of Miconazole Nitrate Mucoadhesive Tablets versus Itraconazole Capsules in the Treatment of Oral Candidiasis: An Open-Label, Randomized, Multicenter Trial. [PDF]

PLoS ONE, 2016
Oral candidiasis (OC) is a common oral fungal infection. Recently, miconazole mucoadhesive tablets have been gaining attention for OC treatment. Despite trials in patients with human immunodeficiency virus and cancer, evidence of its application in the ...
Zhimin Yan, Xiaosong Liu, Yang Liu, Ying Han, Mei Lin, Wenmei Wang, Xiaobing Guan, Shengrong Zhu, Handong Zhang, Qintao Wang, Lihong Chou, Xinghao Zhu, Hong Hua   +12 more
doaj   +1 more source

Repurposing itraconazole as an anticancer agent.

Oncology Letters, 2017
Itraconazole, a common anti-fungal agent, has demonstrated potential anticancer activity, including reversing chemoresistance mediated by P-glycoprotein, modulating the signal transduction pathways of Hedgehog, mechanistic target of rapamycin and Wnt/β ...
H. Tsubamoto, T. Ueda, Kayo Inoue, K. Sakata, H. Shibahara, T. Sonoda   +5 more
semanticscholar   +1 more source

Osimertinib Cost Minimization in Non‐Small Cell Lung Cancer (NSCLC) Treatment: Hypothesis Generation for a Population Pharmacokinetic Approach for Equivalent Dose Optimization of Osimertinib in Combination With Cobicistat

The Journal of Clinical Pharmacology, EarlyView.
Abstract Pharmacokinetic boosting can be a strategy to enhance osimertinib exposure and reduce treatment associated costs. The OSIBOOST trial demonstrated that it was feasible to boost low osimertinib plasma trough levels with cobicistat. The current study aims to establish the equivalent dose of cobicistat boosted osimertinib compared to osimertinib ...
Niels Westra, Paul D. Kruithof, Sander Croes, Robin M. J. M. van Geel, Lizza E. L. Hendriks, Daan J. Touw, Jos G. W. Kosterink, Jasper Stevens, Thijs H. Oude Munnink, Paola Mian   +9 more
wiley   +1 more source

Lack of Functional Trehalase Activity in Candida parapsilosis Increases Susceptibility to Itraconazole

Journal of Fungi, 2022
Central metabolic pathways may play a major role in the virulence of pathogenic fungi. Here, we have investigated the susceptibility of a Candida parapsilosis mutant deficient in trehalase activity (atc1Δ/ntc1Δ strain) to the azolic compounds fluconazole
Ruth Sánchez-Fresneda, María Luz Muñoz-Megías, Genoveva Yagüe, Francisco Solano, Sergi Maicas, Juan Carlos Argüelles   +5 more
doaj   +1 more source

Population Pharmacokinetics of Valemetostat and Exposure–Response Analyses of Efficacy and Safety in Patients with Relapsed/Refractory Peripheral T–Cell Lymphoma

The Journal of Clinical Pharmacology, EarlyView.
Abstract Valemetostat is a dual inhibitor of EZH2/1 approved in Japan for the treatment of relapsed/refractory (R/R) adult T–cell lymphoma/leukemia (ATLL) and R/R peripheral T–cell lymphoma (PTCL). It is administered orally once daily (QD) at 200 mg. Here, we present comprehensive population pharmacokinetic (PPK) and exposure–response (ER) analyses of ...
Hiroyuki Inoue, Xiaoning Wang, Ramon Garcia, Brian Reilly, Masaya Tachibana, YoungJun Yoo, Yvonne Lau, Yang Chen   +7 more
wiley   +1 more source