Results 71 to 80 of about 46,843 (269)

Evaluation of the Drug–Drug Interaction Potential of the GlyT1 Inhibitor Iclepertin (BI 425809): A Physiologically Based Pharmacokinetic (PBPK) Modeling Approach

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Despite predicting poor functional outcomes and being a significant patient burden, there are no approved pharmacotherapies to treat symptoms of cognitive impairment associated with schizophrenia (CIAS). Iclepertin (BI 425809) is a potent and selective inhibitor of glycine transporter‐1 (GlyT1) that was in Phase III development for the ...
Elin M. Matsson, Michael Desch, Valerie Nock, Nina Hanke   +3 more
wiley   +1 more source

Enhancing the in vitro and in vivo activity of itraconazole against breast cancer using miltefosine-modified lipid nanocapsules

Drug Delivery, 2021
Itraconazole (ITC), a well-tolerated antifungal drug, exerts multiple anticancer effects which justified its preclinical and clinical investigation as potential anti-cancer agent with reduced side effects.
Nabila A. El-Sheridy, Riham M. El-Moslemany, Alyaa A. Ramadan, Maged W. Helmy, Labiba K. El-Khordagui   +4 more
doaj   +1 more source

Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis.

ACS Chemical Biology, 2017
The antifungal drug itraconazole was recently found to exhibit potent antiangiogenic activity and has since been repurposed as an investigational anticancer agent. Itraconazole has been shown to exert its antiangiogenic activity through inhibition of the
S. Head, W. Shi, E. Yang, Benjamin A. Nacev, S. Y. Hong, K. Pasunooti, Ruo-Jing Li, J. Shim, Jun O. Liu   +8 more
semanticscholar   +1 more source

PBPK Modeling to Predict Clinical Drug–Drug Interaction and Impact of Hepatic Impairment for an ADC With the Payload Auristatin F‐Hydroxypropylamide

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Upifitamab rilsodotin—an antibody drug conjugate (ADC)—comprises a NaPi2b‐targeted antibody conjugated to an auristatin‐based payload (auristatin F‐hydroxypropylamide [AF‐HPA]). AF‐HPA is metabolized by cytochrome P450 3A4 (CYP3A4) and, to a lower extent, by CYP3A5 and demonstrates both reversible and time‐dependent inhibition of CYP3A4.
Niyanta Kumar, Vaishali Dixit, Howard Burt, Katherine L. Gill, Hannah M. Jones, Natalie Keirstead, Dian Su, Dorin Toader, Timothy B. Lowinger   +8 more
wiley   +1 more source

Itraconazole associated quadriparesis and edema: a case report

Journal of Medical Case Reports, 2011
Introduction Itraconazole is an anti-fungal agent widely used to treat various forms of mycosis. It is particularly useful in allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization. Side effects are uncommon and usually mild.
Denning David W, Kellett Mark, Gow David, Karadi Rangaprasad L, O'Driscoll Ronan B   +4 more
doaj   +1 more source

A Method for Processing Whole Blood for Heterologous Packed Red Blood Cell Transfusion for Use in a Green‐Winged Macaw (Ara chloropterus)

Zoo Biology, EarlyView.
Residual plasma and saline following blood component processing to produce a packed red blood cell unit for transfusion in an anemic green‐winged macaw (Ara cholopterus). ABSTRACT An 11‐year‐old male green‐winged macaw (Ara chloropterus) diagnosed with severe anemia required a packed red blood cell transfusion rather than whole blood based on ...
David J. Minich, Michelle C. Borsdorf, Chloe R. Dupleix, Eleanor Petree, Lily Parkinson   +4 more
wiley   +1 more source

Treatment of sporotrichosis with itraconazole [PDF]

The American Journal of Medicine, 1993
Abstract purpose: To describe the clinical presentation and outcomes of treatment with itraconazole in patients with sporotrichosis. methods: A culture for Sporothrix schenckii or compatible histopathology was required for inclusion in the study. Patients with both cutaneous and systemic sporotrichosis were treated.
Sharkey-Mathis, Patricia Kay, Kauffman, Carol A., Graybill, John R., Stevens, David A., Hostetler, John S., Cloud, Gretchen A., Dismukes, William E.   +6 more
openaire   +3 more sources

Cardiac arrest provoked by itraconazole and amiodarone interaction: a case report

Journal of Medical Case Reports, 2011
Introduction Azoles, and specifically itraconazole, are often prescribed for the treatment of fungal diseases or empirically for persistent sepsis in patients who are neutropenic or in intensive care.
Betrosian Alex, Andrianakis Ilias, Tsimogianni Angeliki M, Douzinas Emmanouil   +3 more
doaj   +1 more source

Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways

OncoTarget, 2017
Malignant melanoma is the deadliest form of all skin cancers. Itraconazole, a commonly used systemic antifungal drug, has been tested for its anti-tumor effects on basal cell carcinoma, prostate cancer, and non-small cell lung cancer.
Guanzhao Liang, Musang Liu, Qiong Wang, Yong-nian Shen, Huan Mei, Dongmei Li, Weida Liu   +6 more
semanticscholar   +1 more source

Emerging Terbinafine Resistant Trichophyton Dermatophytosis, Testing Options and Alternative Treatments: A Systematic Review

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Dermatophytosis is a common superficial fungal infection of the skin, most often caused by dermatophytes from the Trichophyton genus. Terbinafine, which inhibits squalene epoxidase (SQLE), is widely used as first line treatment. However, resistance to terbinafine is increasing globally, including recent reports in Australia, with origins ...
Thuvarahan Jegathees, Zachary P. Holmes, Catherine Martin, Cindy Kalai, Catherine Voutier, Denis Spelman, Gemma Robertson, Johannes S. Kern   +7 more
wiley   +1 more source