Results 71 to 80 of about 47,734 (283)

The Rare Presentation of Deep Dermatophytosis‐Trichophyton in an Immunosuppressed Patient

JEADV Clinical Practice, EarlyView.
ABSTRACT Dermatophytes typically cause superficial skin infections characterized by an active border. However, they can present atypically invading deeper in immunocompromised patients. We present a case of a 72‐year‐old woman with bullous pemphigoid who had received oral prednisolone for 3 months and developed umbilicated papules.
Jidapa Triwatcharikorn, Nitina Yeesibsean, Jirapon Jesrichai, Chanat Kumtornrut   +3 more
wiley   +1 more source

Effects of Food and Omeprazole on a Novel Formulation of Super Bioavailability Itraconazole in Healthy Subjects

Antimicrobial Agents and Chemotherapy, 2018
To address the limited bioavailability and intolerance of the conventional itraconazole (ITZ) formulations, a new formulation labeled super bioavailability (SUBA) itraconazole has been developed; however, the specific effects of food and gastric pH are ...
Julian Lindsay, Stuart Mudge, G. Thompson   +2 more
semanticscholar   +1 more source

Treatment of sporotrichosis with itraconazole [PDF]

The American Journal of Medicine, 1993
Abstract purpose: To describe the clinical presentation and outcomes of treatment with itraconazole in patients with sporotrichosis. methods: A culture for Sporothrix schenckii or compatible histopathology was required for inclusion in the study. Patients with both cutaneous and systemic sporotrichosis were treated.
Sharkey-Mathis, Patricia Kay, Kauffman, Carol A., Graybill, John R., Stevens, David A., Hostetler, John S., Cloud, Gretchen A., Dismukes, William E.   +6 more
openaire   +3 more sources

Study on pharmacokinetic interactions between SHR2554 and itraconazole in healthy subjects: A single‐center, open‐label phase I trial

Cancer Medicine, 2023
Background SHR2554, a novel oral Enhancer of Zeste Homolog 2 inhibitor, shows broad‐spectrum anti‐tumor efficacy in preclinical studies. As SHR2554 is mainly metabolized by CYP3A4, it is helpful to conduct research on the effects of itraconazole, a ...
Kunhong Deng, Yi Zou, Chan Zou, Hong Wang, Yuxia Xiang, Xiaoyan Yang, Shuang Yang, Chang Cui, Guoping Yang, Jie Huang   +9 more
doaj   +1 more source

Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis.

ACS Chemical Biology, 2017
The antifungal drug itraconazole was recently found to exhibit potent antiangiogenic activity and has since been repurposed as an investigational anticancer agent. Itraconazole has been shown to exert its antiangiogenic activity through inhibition of the
S. Head, W. Shi, E. Yang, Benjamin A. Nacev, S. Y. Hong, K. Pasunooti, Ruo-Jing Li, J. Shim, Jun O. Liu   +8 more
semanticscholar   +1 more source

Itraconazole associated quadriparesis and edema: a case report

Journal of Medical Case Reports, 2011
Introduction Itraconazole is an anti-fungal agent widely used to treat various forms of mycosis. It is particularly useful in allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization. Side effects are uncommon and usually mild.
Denning David W, Kellett Mark, Gow David, Karadi Rangaprasad L, O'Driscoll Ronan B   +4 more
doaj   +1 more source

Health‐Related Quality of Life in Stevens‐Johnson Syndrome and Toxic Epidermal Necrolysis: A Qualitative Study

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Epidermal necrolysis (EN), including Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), are severe cutaneous drug reactions with high morbidity. However, the quality of life (QoL) impact during acute hospitalization is not well understood.
Jacob McFeeters, Allison Yan, Cole Veliky, Matthew Gallardo, Kelsey Nusbaum, Rachel Kirven, Kristopher Fisher, Abraham Korman, Hyoshin Kim, Benjamin H. Kaffenberger   +9 more
wiley   +1 more source

Cardiac arrest provoked by itraconazole and amiodarone interaction: a case report

Journal of Medical Case Reports, 2011
Introduction Azoles, and specifically itraconazole, are often prescribed for the treatment of fungal diseases or empirically for persistent sepsis in patients who are neutropenic or in intensive care.
Betrosian Alex, Andrianakis Ilias, Tsimogianni Angeliki M, Douzinas Emmanouil   +3 more
doaj   +1 more source

Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways

OncoTarget, 2017
Malignant melanoma is the deadliest form of all skin cancers. Itraconazole, a commonly used systemic antifungal drug, has been tested for its anti-tumor effects on basal cell carcinoma, prostate cancer, and non-small cell lung cancer.
Guanzhao Liang, Musang Liu, Qiong Wang, Yong-nian Shen, Huan Mei, Dongmei Li, Weida Liu   +6 more
semanticscholar   +1 more source

An Unusual Case Report of Iatrogenic Metrorrhagia and Hematochezia Following Itraconazole

Clinical Dermatology Review
Itraconazole is an effective triazole antimycotic drug that has a desirable pharmacokinetic profile to combat various fungal pathogens. It acts by inhibiting ergosterol biosynthesis in fungal cell membranes.
Yashaswi Rai
doaj   +1 more source