Results 221 to 230 of about 33,630 (280)

5′tRF‐GlyGCC Promotes Breast Cancer Progression via LDHA‐Mediated Glycolysis and Macrophage Polarization

open access: yesAdvanced Science, Volume 13, Issue 9, 13 February 2026.
5’tRF‐GlyGCC promotes breast cancer malignancy by binding to LDHA. This interaction, facilitated by FGFR1 and LDHA phosphorylation, enhances glycolysis. Additionally, 5’tRF‐GlyGCC/LDHA signaling recruits and polarizes macrophages into a pro‐tumor M2 state via CCL7, thus remodeling the tumor microenvironment.
Cheng Yi   +17 more
wiley   +1 more source

Neuroprotective Nanoplatform Integrating Antioxidant MXene Nanozymes and Ferroptosis Inhibitors for Targeted Therapy of Cerebral Ischemia‐Reperfusion Injury

open access: yesAdvanced Science, Volume 13, Issue 7, 3 February 2026.
Cerebral ischemia‐reperfusion injury (CIRI) is a key pathological process limiting the efficacy of stroke therapy. This study has developed an innovative, multifunctional, brain‐targeted nanoplatform (RFP) containing MXene nanoenzymes and ferroptosis inhibitors.
Lu Wang   +9 more
wiley   +1 more source

Quantitative Genetic Variation and Response for Harvest Body Weight in a Selection Program for Red Tilapia (Oreochromis spp.)

open access: yesAquaculture, Fish and Fisheries, Volume 6, Issue 1, February 2026.
ABSTRACT Genetic variation is indispensable for both natural and artificial selection, as well as evolution, adaptation, and the long‐term success of selective breeding programs. This study attempted to scrutinise genetic variations and responses within the breeding population of red tilapia across eight generations of selection (2016–2023).
Tran Huu Phuc   +7 more
wiley   +1 more source

Carbon dot-lipidoid nanocarriers for superiorly biocompatible nasal mRNA cancer vaccination. [PDF]

open access: yesJ Nanobiotechnology
Kim H   +7 more
europepmc   +1 more source

Large Language Models for Clinical Trial Protocol Assessments

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 393-402, February 2026.
The purpose was to evaluate the utility of large language models (LLMs) for reviewing the statistical analysis plan (SAP) and pharmacokinetics–pharmacodynamics (PK–PD) components of clinical trial protocols. Clinical trial protocols and SAPs were obtained from clinicaltrials.gov for a testbed of 15 small‐molecule drugs, biologics, and global antibiotic
Euibeom Shin   +2 more
wiley   +1 more source

Protective Effects of Myrtus communis Essential Oil Against Bisphenol A‐Induced Metabolic Dysfunction‐Associated Fatty Liver Disease in Wistar Rats

open access: yesFood Science &Nutrition, Volume 14, Issue 2, February 2026.
Exposure to bisphenol A (BPA) induced hepatic steatosis associated with metabolic dysfunction (MASLD) in Wistar rats, characterized by dyslipidemia, oxidative stress, and hepatic steatosis. Co‐treatment with essential oil of myrtus communis (EOMC) improved markers of liver function, lipid profile, and antioxidant status, with histological improvement ...
Mhimdi Mariem   +6 more
wiley   +1 more source

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