Results 31 to 40 of about 1,762 (180)

4IR integration of information technology best practice framework in operational technology

Journal of Industrial Engineering and Management, 2021
Purpose: Since inception in the 1970s, Operational Technology (OT) systems were designed to operate in isolation from Information Technology (IT) systems mainly due to differences in objectives relating to Confidentiality, Integrity, Security and ...
Musa Shilenge, Arnesh Telukdarie
doaj   +1 more source

Regulation of Immune Checkpoints: From Molecular Mechanisms to Clinical Therapies

MedComm, Volume 7, Issue 6, June 2026.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by unleashing antitumor immunity. This review comprehensively examines the molecular mechanisms underlying key immune checkpoints—including PD‐1/PD‐L1, CTLA‐4, and TIM‐3—and their clinical applications.
Qintao Ge, Liu Yu, Jiahe Lu, Aihetaimujiang Anwaier, Xiyue Xiao, Yonghao Chen, Dingwei Ye, Hailiang Zhang, Wenhao Xu, Wenbin Dai   +9 more
wiley   +1 more source

МЕТРИКИ ОЦІНКИ ЯКОСТІ РОБОТИ СИСТЕМИ ОБРОБКИ ЗВЕРНЕНЬ ДО СЛУЖБИ ТЕХНІЧНОЇ ПІДТРИМКИ

Автоматизация технологических и бизнес-процессов
Анотація. В цьому дослідженні розглядається питання оцінки якості роботи підрозділу технічної підтримки за допомогою дослідження ряду показників якості - метрик.
Максим Ігорович Дьяченко, Андрій Анатолійович Роскладка   +1 more
doaj   +1 more source

Protein tyrosine phosphatases as emerging targets for cancer immunotherapy

British Journal of Pharmacology, Volume 183, Issue 6, Page 1233-1249, March 2026.
Abstract Contemporary strategies in cancer immunotherapy, despite remarkable success, remain constrained by inherent limitations such as suboptimal patient responses, the emergence of drug resistance, and the manifestation of pronounced adverse effects. Consequently, the need for alternative strategies for immunotherapy becomes clear.
Zihan Qu, Jiajun Dong, Zhong‐Yin Zhang
wiley   +1 more source

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, Volume 183, Issue 6, Page 1250-1270, March 2026.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

How small and medium enterprises can begin their implementation of ITIL?

Revista Facultad de Ingeniería Universidad de Antioquia, 2015
La secuenciación de los procesos de la Biblioteca de Infraestructura de Tecnologías de Información (ITIL) en cuanto a su orden de implementación es un aspecto no abordado en sus libros.
Jose Antonio Calvo-Manzano, Lohana Lema-Moreta, Magdalena Arcilla-Cobián, Juan Luis Rubio-Sánchez   +3 more
doaj  

Performance of RAP-Based HRS-WC Mixtures Using Natural Rubber as Rejuvenator

Jurnal Ilmiah Telsinas
The growing demand for road pavement materials has encouraged the use of Reclaimed Asphalt Pavement (RAP) as a sustainable alternative. However, binder aging in RAP increases mixture stiffness, requiring rejuvenating agents to restore asphalt properties.
I Made Agus Ariawan, Andre Wisnu kusuma, I Nyoman Arya Thanaya   +2 more
doaj   +1 more source

نموذج مقترح للمحاسبة عن كلف تقنية المعلومات )ITSM( على وفق متطلبات إطار إدارة خدمات تقنية المعلومات

Tikrit Journal of Administrative and Economic Sciences, 2022
يناقش البحث الحالي العلاقة بين إطار ادارة خدمات تقنية المعلومات المستخدمة في المحاسبة عن كلف خدمات تقنية المعلومات مستعرضا تأثير التوجه بالخدمات في على نماذج التكاليف التقليدية وقصور هذه النماذج )ITSM( إطار ادارة خدمات تقنية المعلومات عن تلبية متطلبات ...
Khalid Gazi A. Al-Temi, Muthana Falih bader   +1 more
doaj   +1 more source

T‐cell exhaustion from a multiomics perspective: Differentiation mechanisms and regulatory networks in the journey from progenitor‐Exhausted T cells to terminally exhausted T cells

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
(1) Core Process: Persistent antigen, from TDLNs to TME, drives Tpex → Tex‐int → Tex‐term differentiation. (2) Multiomics Regulation: This fate transition is orchestrated by a co‐ordinated, multi‐layered molecular network. (3) Functional Outcome: Dysregulated signalling and surging co‐inhibitory receptors lock in proliferative arrest and functional ...
Tong Zhu, Xiaoyu Teng, Qinlian Jiao, Yidan Ren, Yunshan Wang, Maoxiao Feng   +5 more
wiley   +1 more source

T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Hepatocellular carcinoma (HCC), accounting for over 90% of primary liver cancers, remains a major global challenge for healthcare professionals. While immunotherapy has transformed the landscape of cancer treatment, its success is often limited by immune resistance, particularly through T cell exhaustion which remains a major barrier to ...
Kosar Nouri, Negar Asadollahei, Yasamin Haghir‐Sharif‐Zamini, Homeyra Seydi, Mahsa Salehi, Mehrnaz Mesdaghi, Mustapha Najimi, Massoud Vosough   +7 more
wiley   +1 more source