Results 121 to 130 of about 66,840 (318)

Ivermectin inhibits canine mammary tumor growth by regulating cell cycle progression and WNT signaling

BMC Veterinary Research, 2019
Background Mammary gland tumor is the most common spontaneous tumor in intact female dogs, and its poor prognosis remains a clinical challenge. Ivermectin, a well-known anti-parasitic agent, has been implicated as a potential anticancer agent in various ...
Hongxiu Diao, Nan Cheng, Ying Zhao, Huihao Xu, Haodi Dong, Douglas H. Thamm, Di Zhang, Degui Lin   +7 more
doaj   +1 more source

Lack of efficacy of standard doses of ivermectin in severe COVID-19 patients.

PLoS ONE, 2020
Ivermectin has recently shown efficacy against SARS-CoV-2 in-vitro. We retrospectively reviewed severe COVID-19 patients receiving standard doses of ivermectin and we compared clinical and microbiological outcomes with a similar group of patients not ...
Daniel Camprubí, Alex Almuedo-Riera, Helena Martí-Soler, Alex Soriano, Juan Carlos Hurtado, Carme Subirà, Berta Grau-Pujol, Alejandro Krolewiecki, Jose Muñoz   +8 more
doaj   +1 more source

The Prevalence of Scabies, Skin Infection and Rheumatic Heart Disease in a Cross‐Sectional Study of Tongan Primary School Children

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Background Scabies is a common health issue in the Pacific and may contribute to rheumatic heart disease (RHD). This study assessed the prevalence of scabies and other skin conditions among Tongan schoolchildren and examined the association between these conditions and RHD.
Simon Thornley, Toakase Fakakovikaetau, Mele Tilema Cama, Mele ‘Atuekaho Manu, Kalolaine Tahitua, Shunsuke Moritsuka, Richard J. Johnson, Viliami Puloka, Losana Vuki, Joseph Takai, Jacqui Williamson, Saptorshi Gupta, Arthur J. Morris, Gerhard Sundborn   +13 more
wiley   +1 more source

Structural model, functional modulation by ivermectin and tissue localization of Haemonchus contortus P-glycoprotein-13

International Journal for Parasitology: Drugs and Drug Resistance, 2018
Haemonchus contortus, one of the most economically important parasites of small ruminants, has become resistant to the anthelmintic ivermectin. Deciphering the role of P-glycoproteins in ivermectin resistance is desirable for understanding and overcoming
Marion David, Chantal Lebrun, Thomas Duguet, Franck Talmont, Robin Beech, Stéphane Orlowski, François André, Roger K. Prichard, Anne Lespine   +8 more
doaj   +1 more source

The macrofilaricidal efficacy of repeated doses of ivermectin for the treatment of river blindness [PDF]

, 2017
Background: Mass drug administration (MDA) with ivermectin is the cornerstone of efforts to eliminate human onchocerciasis by 2020 or 2025. The feasibility of elimination crucially depends on the effects of multiple ivermectin doses on Onchocerca ...
Basáñez, Maria-Gloria, Boussinesq, Michel, Chesnais, Cédric, Chippaux, Jean-Philippe, Ernould, Jean-Christophe, Fang, Hanwei, Garcia, André, Gardon, J., Kamgno, Joseph, Pion, Sébastien, Ranque, Stephane, Tchatchueng-Mbougua, Jules Brice, Walker, Martin   +12 more
core   +3 more sources

Comparison of Human and Canine P‐Glycoprotein Substrates at R, P, and H Binding Sites

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT P‐glycoprotein (P‐gp) greatly impacts substrate drug disposition, so much so that regulatory agencies recommend ascertaining the P‐gp status of active pharmaceutical ingredients (APIs) intended for human use. Arguably, the P‐gp status of drugs intended for canine patients is equally, if not more, important.
Neal S. Burke, Katrina L. Mealey
wiley   +1 more source

Development of an in vitro drug sensitivity assay for Trichuris muris first-stage larvae [PDF]

, 2013
Trichuriasis represents a major public health problem in the developing world and is regarded as a neglected disease. Albendazole and mebendazole, the two drugs of choice against trichuriasis display only moderate cure rates, hence alternative drugs are ...
Keiser, Jennifer, Tritten, Lucienne, Wimmersberger, David   +2 more
core   +2 more sources

Reading Nietzsche in an Age of Conspiracy Theories

Modern Theology, EarlyView.
Abstract This essay considers Friedrich Nietzsche's critique of Christian morality as a template for interpreting the epistemology of modern conspiracy theorists. The first section elucidates Nietzsche's notion of ressentiment as it can be applied to contemporary conspiracism. The effectiveness of this comparative assessment thus raises the question of
J.W. Olson
wiley   +1 more source

Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta [PDF]

, 2017
Preventive chemotherapy has long been practiced against nematode parasites of livestock, leading to widespread drug resistance, and is increasingly being adopted for eradication of human parasitic nematodes even though it is similarly likely to lead to ...
Bisset, Stewart A, Choi, Young-Jun, Doyle, Stephen R, Grant, Warwick N, Hallsworth-Pepin, Kymberlie, Martin, John, Mitreva, Makedonka   +6 more
core   +4 more sources

Drivers of Noncompliance With Vaccine Mandates—The Interplay Between Distrust, Rationality, Morality, and Social Motivation

Regulation &Governance, EarlyView.
ABSTRACT COVID‐19 amplified the issue of public resistance to government vaccination programs. Little attention has focused on people's moral reasons for noncompliance, which differ from—but often build upon—the epistemic claims they make about vaccine safety and efficacy, disease severity, and the trustworthiness of government. This study explores the
Katie Attwell, Hang Duong, Amy Morris, Leah Roberts, Mark Navin   +4 more
wiley   +1 more source