Results 101 to 110 of about 22,962,330 (351)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Experimental Determination and Numerical Calculation of Fracture Viscosity Criterion (J-integral)

open access: yesНаука и техника, 2005
The paper shows that it is necessary to accept energy J-integral criterion as a criterion of fracture viscosity under conditions when the zone of plasticity is rather large at crack top.
V. N. Kovalevsky   +3 more
doaj   +1 more source

Correlation between the pivot node concept and fatigue crack closure [PDF]

open access: yes, 2018
The study of fatigue crack growth has been commonly done by means of bi-dimensional models and assuming a homogeneous behaviour through the thickness. According to the specimen thickness, a state of plane stress or plane strain is presumed.
Camas, Daniel   +2 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Effect of shot peening on J-integral and crack propagation rate of semi-elliptic surface crack on Ti6Al4V

open access: yesCailiao gongcheng, 2019
Considering the residual stress, residual strain and residual strain energy, the influence of shot peening on the J-integral parameters of semi-elliptic surface crack front was quantitatively calculated and analyzed.
HOU Shuai   +3 more
doaj   +1 more source

Fracture mechanics analysis of damaged turbine rotor discs using finite element method [PDF]

open access: yes, 2014
This paper presents evaluation fracture mechanics parameters in low pressure turbine components. Critical locations such as keyway and dovetail area are experiencing stress concentration leading to crack initiation. Stress intensity factors were
Bakić Gordana M.   +5 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A proposed approach to the application of nonlinear irreversible thermodynamics to fracture in composite materials [PDF]

open access: yes
The fracture criteria upon which most fracture mechanics is based involves an energy balance that is not appropriate for the fracture mechanics of viscoelastic materials such as polymer matrix composites.
Lindenmeyer, P. H.
core   +1 more source

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