Results 121 to 130 of about 22,686,556 (351)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A Study on J-Integral as a Fracture Criterion

Journal of the Society of Naval Architects of Japan, 1975
The J-integral has been proposed as an engineering fracture criterion for elastic-plastic behavior in metals.The J-integral, as is defined, has several advantages over some other currently used fracture parameters. But the experimental evidence so far obtained to show its practical usefulness have been limited.Using an ordinary ship steel, the authors ...
Takeshi Kanazawa, Susumu Machida, Shigehiro Kaneda, Masakazu Onozuka   +3 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A proposed approach to the application of nonlinear irreversible thermodynamics to fracture in composite materials [PDF]

The fracture criteria upon which most fracture mechanics is based involves an energy balance that is not appropriate for the fracture mechanics of viscoelastic materials such as polymer matrix composites.
Lindenmeyer, P. H.
core   +1 more source

Experimental investigation on possible dependence of plastic zone size on specimen geometry [PDF]

, 2009
In this investigation the extent of the plastic zone size ahead of a crack-tip in single edge notched tension (SENT), compact tension (CT) specimens has been examined experimentally by micro-hardness technique and by elastic-plastic finite element ...
B. Maiti, K. K. Ray, S. K. Kudari
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

R curve obtained by a round bar with a circumferential crack and its effectiveness for a fracture toughness test (For a material with medium fracture toughness)

Nihon Kikai Gakkai ronbunshu
A non-standard circumferentially cracked round bar (CRB) specimen has been examined for replacement of the standard fracture toughness CT specimen since 1981.
Koichi KASABA, Shinichiro MORISHITA, Tatsuya SUGITANI   +2 more
doaj   +1 more source

Analysis of stevia extract and compare active functional group with other artificial sweetener; aspartame and sucralose [PDF]

, 2020
Sugar is very important for everyday use especially for humans as food and drinks as additives. Among all types of sweeteners; sucrose, aspartame and sucralose are widely used in foods and beverage industries.
Ismail, Siti Nur Bahirah, Makminin, Suhaimi, Mohd Yusuf, Siti Maisarah, Othman, Sabariah   +3 more
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source