Results 121 to 130 of about 22,962,330 (351)
Double noding technique for mixed mode crack propagation studies [PDF]
A simple dynamic finite element algorithm for analyzing a propagating mixed mode crack tip is presented. A double noding technique, which can be easily incorporated into existing dynamic finite element codes, is used together with a corrected J integral ...
Emergy, A. F. +2 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Visualizing the crack driving force through fluid analogy
Journal of the Mechanical Behavior of Materials, 2019 It is shown that the crack driving force for a fundamental antiplane crack problem is analogous to the limiting case of the force acting on an ideal fluid on free streamlines that form at the ends of flow around two parallel plates.
Unger David J.
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Calculation and Analysis of Crack Stress Intensity Factor and
Jixie chuandong, 2020 The distribution of stress intensity factor and J integral of helical gear with three-dimensional crack under different initial crack parameters is studied. The finite element software is used to analyze the helical gear with initial crack.
Guangyao Sun +2 more
doaj
Experimental evaluation of contour J integral and energy dissipated in the fracture process zone
, 2014 The fracture mechanics of ductile thin wall is different from that of thick wall materials which is standardly used in fracture mechanics testing. An appropriate determination of the fracture toughness of thin wall materials can be provided by the direct
D. Vavřík, I. Jandejsek
semanticscholar +1 more source
Modelling the double cantilever beam test with bending moments by using bilinear discontinuous cohesive laws [PDF]
, 2015 A theoretical model of the double cantilever beam tests with bending moments (DCB-UBM) is presented. The specimen is modelled as the assemblage of two laminated beams connected by a cohesive interface.
Sørensen, Bent F. +2 more
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source