Glycoengineering of αGal xenoantigen on recombinant peptide bearing the J28 pancreatic oncofetal glycotope [PDF]
In human pancreatic adenocarcinoma, alterations of glycosylation processes leads to the expression of tumor-associated carbohydrate antigens, representing potential targets for cancer immunotherapy. Among these pancreatic tumor-associated carbohydrate antigens, the J28 glycotope located within the O-glycosylated mucin-like C-terminal domain of the ...
Muriel Aubert+6 more
openaire +4 more sources
The formation of the oncofetal J28 glycotope involves core-2 6-N-acetylglucosaminyltransferase and a3/4-fucosyltransferase activities [PDF]
The feto-acinar pancreatic protein or FAPP, the oncofetal glycoisoform of bile salt-dependent lipase (BSDL), is characterized by the presence of the J28 glycotope recognized by mAbJ28. This fucosylated epitope is carried out by the O-linked glycans of the C-terminal mucin-like region of BSDL.
Marie-Odile Sadoulet+6 more
openaire +4 more sources
The oncofetal J28 epitope involves fucosylated O-linked oligosaccharide structures of the fetoacinar pancreatic protein [PDF]
The fetoacinar pancreatic protein (FAP), characterized by the mAb J28, is an oncofetal form of bile salt dependent lipase (BSDL), the expression of which is related to pancreatic differentiation and neoplastic processes. Because the J28 epitope, recognized by mAb J28, is suggested to be dependent upon carbohydrates, we have attempted to gain ...
Dominique Lecestre+6 more
openaire +5 more sources
Comparative efficacy and safety of ilunocitinib and oclacitinib for the control of pruritus and associated skin lesions in dogs with atopic dermatitis. [PDF]
Background – Janus kinase inhibitors (JAKi) have been shown to reduce pruritus and improve associated inflammatory skin lesions in canine atopic dermatitis (cAD). Objective – To evaluate the efficacy and safety of ilunocitinib, in comparison to oclacitinib, for the control of cAD in a randomised, blinded trial.
Forster S+4 more
europepmc +2 more sources
Extracorporeal membrane oxygenation for prevention of barotrauma in patients with respiratory failure: A scoping review. [PDF]
Visual abstract presenting main article structure, objective, research methodology, and results. Abstract Background Barotrauma is a frequent complication in patients with severe respiratory failure and is associated with poor outcomes. Extracorporeal membrane oxygenation (ECMO) implantation allows to introduce lung‐protective ventilation strategies ...
Belletti A+11 more
europepmc +2 more sources
Ranking of management factors for safe maintenance system based on Grey Systems Theory
The maintenance system is a key system that provides continuity and safety of the operation of production systems and that affects the safety of people working in these systems.
Tabor Joanna
doaj +1 more source
Implications of Emotional Intelligence in Human Resource Management
This article reflects an applied theoretical study that addresses the relationship between emotional intelligence, occupational stress, motivation and job satisfaction in the employees of a machine tool manufacturer.Emotional intelligence is very ...
Dâmbean Camelia Angelica+1 more
doaj +1 more source
Editorial: Italy’s “Charter of Workers’ Rights” turns fifty
This short editorial introduces the contributions to a special issue celebrating the fiftieth anniversary of the Italian Statuto dei lavoratori (Charter of Workers’ Rights).
Carlo D'Ippoliti
doaj +1 more source
Abstract Amid a global war for accounting talent, this paper extends our understanding of early career accountants’ (ECAs) career values and the alignment between their career expectations and experiences when entering the profession. Drawing on survey data from 305 ECAs and 165 managers/recruiters of ECAs in Australia, the paper uses social cognitive ...
Denise Jackson+3 more
wiley +1 more source
Background – Pruritus is one of the most common reasons for dermatological consultations in the veterinary clinic. Treatment is normally multimodal and requires continuous monitoring and reassessment. New therapies are needed to broaden the therapeutic arsenal.
Xavier Serra Fabregat+5 more
wiley +1 more source