Results 11 to 20 of about 1,053 (204)

The Use of DeepQSAR Models for the Discovery of Peptides With Enhanced Antimicrobial and Antibiofilm Potential. [PDF]

Mol Inform
A DeepQSAR framework integrating a feed‐forward neural network and a recurrent neural network (RNN) was developed to identify antimicrobial peptides with enhanced antibiofilm and antimicrobial activity. The feed‐forward model was trained on in‐house antibiofilm IC50 data to capture quantitative structure–activity relationships, and its learned features
You J, Mslati H, Haney EF, Akhoundsadegh N, Hancock REW, Cherkasov A.   +5 more
europepmc   +2 more sources

The oncofetal J28 epitope involves fucosylated O-linked oligosaccharide structures of the fetoacinar pancreatic protein [PDF]

Glycobiology, 1997
The fetoacinar pancreatic protein (FAP), characterized by the mAb J28, is an oncofetal form of bile salt dependent lipase (BSDL), the expression of which is related to pancreatic differentiation and neoplastic processes. Because the J28 epitope, recognized by mAb J28, is suggested to be dependent upon carbohydrates, we have attempted to gain ...
Jean-Claude Michalski, M J Escribano, Dominique Lombardo   +2 more
exaly   +3 more sources

Glycoengineering of αGal xenoantigen on recombinant peptide bearing the J28 pancreatic oncofetal glycotope [PDF]

Glycobiology, 2007
In human pancreatic adenocarcinoma, alterations of glycosylation processes leads to the expression of tumor-associated carbohydrate antigens, representing potential targets for cancer immunotherapy. Among these pancreatic tumor-associated carbohydrate antigens, the J28 glycotope located within the O-glycosylated mucin-like C-terminal domain of the ...
Dominique Lombardo, Eric Mas, Lombardo Dominique   +2 more
exaly   +3 more sources

Routine Monitoring of CAR-T-Cells Expansion and Persistence in Patients With Aggressive Large B-Cell Lymphoma by Flow Cytometry: A Single-Center Experience. [PDF]

Hematol Oncol
ABSTRACT This retrospective, single‐center study evaluated routine flow cytometry (FC) monitoring of CAR‐T‐cells in 45 patients with aggressive large B‐cell lymphoma (LBCL). CAR‐T‐cells expansion was assessed from Day 0 to Month 12. Peak expansion occurred on Day 7 after axi‐cel (median 39.3% of total lymphocytes; 87 cells/mm3) and Day 10 for tisa‐cel (
Zduniak A, Martinet J, Lévêque E, Becker S, Tonnelet D, Santos ED, Leroy C, Alani M, Rouvet J, Brousseau M, Giverne C, Cuffel A, Jacquot S, Roucheux A, Veuiller A, Lecornu N, Norbert ME, Boyer O, Tilly H, Jardin F, Latouche JB, Camus V.   +21 more
europepmc   +2 more sources

Comparative efficacy and safety of ilunocitinib and oclacitinib for the control of pruritus and associated skin lesions in dogs with atopic dermatitis. [PDF]

Vet Dermatol
Background – Janus kinase inhibitors (JAKi) have been shown to reduce pruritus and improve associated inflammatory skin lesions in canine atopic dermatitis (cAD). Objective – To evaluate the efficacy and safety of ilunocitinib, in comparison to oclacitinib, for the control of cAD in a randomised, blinded trial.
Forster S, Boegel A, Despa S, Trout C, King S.   +4 more
europepmc   +2 more sources

The formation of the oncofetal J28 glycotope involves core-2  6-N-acetylglucosaminyltransferase and a3/4-fucosyltransferase activities [PDF]

Glycobiology, 1999
The feto-acinar pancreatic protein or FAPP, the oncofetal glycoisoform of bile salt-dependent lipase (BSDL), is characterized by the presence of the J28 glycotope recognized by mAbJ28. This fucosylated epitope is carried out by the O-linked glycans of the C-terminal mucin-like region of BSDL.
Eric Pasqualini, Dominique Lombardo
exaly   +3 more sources

Extracorporeal membrane oxygenation for prevention of barotrauma in patients with respiratory failure: A scoping review. [PDF]

Artif Organs
Visual abstract presenting main article structure, objective, research methodology, and results. Abstract Background Barotrauma is a frequent complication in patients with severe respiratory failure and is associated with poor outcomes. Extracorporeal membrane oxygenation (ECMO) implantation allows to introduce lung‐protective ventilation strategies ...
Belletti A, D'Andria Ursoleo J, Piazza E, Mongardini E, Paternoster G, Guarracino F, Palumbo D, Monti G, Marmiere M, Calabrò MG, Landoni G, Zangrillo A.   +11 more
europepmc   +2 more sources

Effect of black bean supplemented with wheat bran sourdough fermentation by Pediococcus acidilactici or Pediococcus pentosaceus on baking quality and staling characteristics of wheat composite bread

Applied Food Research
The effects of black bean supplemented with wheat bran sourdough fermented by phytase and β-glucosidase producing Pediococcus acidilactici (L19) and Pediococcus pentosaceus (J28), respectively, on baking quality and staling characteristics of wheat ...
Jing Huang, Jacob Ojobi Omedi, Chengye Huang, Cheng Chen, Li Liang, Jianxian Zheng, Yongqing Zeng, Yan Xu, Weining Huang   +8 more
doaj   +2 more sources

Identification and genetic study of lactic acid bacteria from intestine of domestic chickens (Gallus gallus domesticus)

Indonesian Journal of Biotechnology
The gastrointestinal tract is one of the habitats of lactic acid bacteria (LAB). This research aims to identify the LAB isolated from the intestines of domestic chickens (Gallus gallus domesticus) based on phenotypic and genotypic characteristics.
Ixora Sartika Mercuriani, Heru Nurcahyo, Bernadetta Octavia, Astuti Astuti, Adinda Yuslia Rukmanandita, Fita Nilasari   +5 more
doaj   +2 more sources

Machine Learning–Assisted Metabolic Characteristics for Revealing the Key Functionality of Wholemeal Sourdough Bread

International Journal of Food Science
This study employed metabolomic profiling, in vitro cell models, and transcriptomic analysis to investigate the protective effects and mechanisms of metabolites from lactic acid bacteria (LAB)–fermented wholemeal sourdough bread against ...
Cheng Chen, Anqi Wang, Xinyu Guo, Bowen Diao, Haotian Wu, Ming Ning, Peng Yu, Weining Huang, Ning Li, Chris Blanchard, Bing Wang, Zhongkai Zhou   +11 more
doaj   +2 more sources