Results 91 to 100 of about 509,621 (191)

Methotrexate Is a JAK/STAT Pathway Inhibitor [PDF]

, 2015
Background: The JAK/STAT pathway transduces signals from multiple cytokines and controls haematopoiesis, immunity and inflammation. In addition, pathological activation is seen in multiple malignancies including the myeloproliferative neoplasms (MPNs ...
Martin P Zeidler, Sarah J. Danson (764117), Fisher, K.H., Stephen Brown, Katherine H. Fisher (764116), Danson, S.J., Stephen Brown (636639), John A Snowden, John A. Snowden (562909), Sarah J Danson, Thomas, S., Sally Thomas, Martin P. Zeidler (583629), Katherine H Fisher, Sally Thomas (764115), Brown, S., Snowden, J.A., Zeidler, M.P.   +17 more
core   +2 more sources

SnapShot: Jak-STAT Signaling II

, 2020
The JAK-STAT pathway is an evolutionarily conserved signal transduction paradigm, providing mechanisms for rapid receptor-to-nucleus communication and transcription control.
Villarino, Alejandro V, Kanno, Yuka, Gadina, Massimo, O'Shea, John J   +3 more
core   +1 more source

A JAK/STAT invasion

The Journal of Cell Biology, 2002
![Graphic][1] Border cells (arrowhead) don't migrate when the JAK/STAT pathway is not activated (right). Montell/ElsevierAsignalingpathway that is critical in fly eggs might be a key to understanding cancer cell metastasis, according to Debra Silver and Denise Montell (Johns ...
openaire   +2 more sources

Research Advances of JAK/STAT Signaling Pathway in Lung Cancer

Chinese Journal of Lung Cancer, 2019
Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is one of the downstream pathways of cytokine signaling transduction. It regulates cell development, differentiation, proliferation, apoptosis and so on.
Xin YANG, Zhe TANG, Peng ZHANG, Li ZHANG
doaj   +1 more source

Rare germline JAK/STAT variants in a Korean cohort amplify innate immune responses to vaccination

iScience
Summary: The JAK/STAT signaling pathway regulates cytokine-driven responses. Here we investigated the biological impact of germline single nucleotide variants in JAK kinases and STAT transcription factors in vaccine response.
Hye Kyung Lee, Gyuhyeok Cho, Jin Won Huh, Priscilla A. Furth, Jungwook Kim, Lothar Hennighausen   +5 more
doaj   +1 more source

JAK-STAT pathway activation compromises nephrocyte function in a Drosophila high-fat diet model of chronic kidney disease

eLife
Chronic kidney disease is a major health issue and is gaining prevalence. Using a Drosophila model for chronic kidney disease, we show that a high-fat diet (HFD) disrupts the slit diaphragm filtration structure in nephrocytes, the fly functional ...
Yunpo Zhao, Jianli Duan, Hannah Seah, Joyce van de Leemput, Zhe Han   +4 more
doaj   +1 more source

JAK-STAT signaling in asthma [PDF]

Journal of Clinical Investigation, 2002
Alessandra B, Pernis, Paul B, Rothman
openaire   +2 more sources

Scheme of the JAK-STAT pathway.

, 2013
Scheme of the JAK-STAT pathway.
Xiaodian Sun (375829), Momiao Xiong (86978), Li Jin (40265)   +2 more
core   +1 more source

JAK/STAT pathway dysregulation in tumors:a Drosophila perspective

, 2014
Sustained activation of the JAK/STAT pathway is causal to human cancers. This pathway is less complex in Drosophila, and its dysregulation has been linked to several tumor models in this organism.
Amoyel, Marc, Bach, Erika A, Anderson, Abigail M   +2 more
core   +1 more source

Effect of silibinin on GAS6/sAXL and JAK/STAT pathways in human cholangiocarcinoma cell line

Türk Biyokimya Dergisi
Cholangiocarcinoma (CCA) is a highly heterogeneous biliary malignant tumor. Studies have demonstrated that JAK/STAT signaling is activated in many types of cancer. In addition, JAK/STAT is activated downstream of AXL, and the AXL receptor is activated by
Caliskan Zehra Nur, Ozel Yetkin Merve, Baskol Mevlut, Baskol Gulden   +3 more
doaj   +1 more source