Results 81 to 90 of about 509,621 (191)

Mining for JAK-STAT mutations in cancer.

, 2008
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway mediates signaling by cytokines, which control survival, proliferation and differentiation of several cell types.
Girardot, Michaël, Constantinescu, Stefan N., Pecquet, Christian   +2 more
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JAK-STAT Signaling and Inhibition in Immunological Diseases [PDF]

, 2022
Janus kinaasi (JAK) – signaalinvälittäjä ja transkriptioaktivaattori (STAT) reitti on yksi keskeisimmistä signaalinvälitysreiteistä kehoissamme.
Palmroth, Maaria
core  

Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway

Frontiers in Immunology
Ulcerative colitis (UC) is an autoimmune disease with an incompletely understood pathogenesis. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway plays a key role in immune response and inflammation. More and
Dan Long, Chenhan Mao, Wei Zhang, Ying Zhu, Yin Xu   +4 more
doaj   +1 more source

JAK/STAT signaling in renal diseases [PDF]

, 2010
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is a pleiotropic cascade essential to cytokine and growth hormone receptor signaling.
John C. He, Chuang, Peter Y., He, John C., Peter Y. Chuang   +3 more
core   +1 more source

JAK-STAT signaling and myocardial glucose metabolism

, 2013
JAK-STAT signaling occurs in virtually every tissue of the body, and so does glucose metabolism. In this review, we summarize the regulation of glucose metabolism in the myocardium and ponder whether JAK-STAT signaling participates in this regulation ...
Frias, Miguel, Montessuit, Christophe Albert   +1 more
core   +1 more source

Protein phosphatase 2A inhibits interferon signaling through the Jak STAT pathway and promotes hepatitis C viral replication [PDF]

, 2014
The first part of the work demonstrate the role of PP2A in IFN-α induced Jak-STAT1 signaling and HCV replication. We show here that PP2Ac activity is not required for IFN-α induced tyrosine phosphorylation of Jak1/Tyk2 and STAT1.
Shanker, Vijay
core   +1 more source

Transient JAK/STAT pathway inhibition prevents natural occurring B-ALL development in genetically predisposed Pax5+/- mice

, 2022
Preventing development of childhood B-cell acute lymphoblastic leukemia (B-ALL), a disease with devastating effects, is a longstanding and unsolved challenge.
Isidro-Hernández, Marta, Alemán-Artega, Silvia, Mayado, Andrea, Prieto-Matos, Pablo, Criado, Francisco Javier García, Cobaleda, César, Orfao, Alberto, Yang, Jun J, Oak, Ninad, Riesco, Susana, Alonso-López, Diego, Weiss, Andreas, Nichols, Kim E, Sánchez-García, Isidro, Vicente-Dueñas, Carolina, Cenador, María Begoña García, Buhles, Alexandra, Mann-Ran, Christine, Radimerski, Thomas, De Las Rivas, Javier, Raboso-Gallego, Javier, Sterker, Dario, Casado-García, Ana, Blanco, Oscar, Ramírez-Orellana, Manuel   +24 more
core   +1 more source

Insect dome receptor directly recognizes viral envelopes to activate JAK/STAT signaling and induce conserved antiviral viperin expression

Cell Reports
Summary: Insect Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway plays a crucial role in antiviral defense, yet how arboviruses activate this pathway remains unclear.
Siyu Chen, Yupeng Tang, Chunyu Zhang, You Li, Dongsheng Jia, Taiyun Wei   +5 more
doaj   +1 more source

Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation [PDF]

, 2017
Constitutive JAK-STAT signaling drives the proliferation of most myeloproliferative neoplasms (MPN) and a subset of acute myeloid leukemia (AML), but persistence emerges with chronic exposure to JAK inhibitors.
Madeleine E. Lemieux, Qiang Jeremy Wen, Levine, Ross L, Shair, Matthew D, Sara C. Meyer, Shair, Matthew, John D. Crispino, Nitulescu, Ioana I, Lemieux, Madeleine E, Ross L. Levine, Henry E. Pelish, Pelish, Henry E, Lemieux, Madeleine E., Ioana I. Nitulescu, Levine, Ross L., Crispino, John D, Wen, Qiang Jeremy, Meyer, Sara C., Pelish, Henry E., Crispino, John D., Nitulescu, Ioana I., Matthew D. Shair   +21 more
core   +2 more sources

Mutacje genów JAK i STAT a aktywacja szlaku JAK–STAT w nowotworach limfo- i mieloproliferacyjnych

, 2022
Nowotwory limfo- oraz mieloproliferacyjne są heterogenną grupą chorób komórki macierzystej szpiku (HSC). Wykazano, że w większości z nich transformacja nowotworowa jest wynikiem nabycia przez HSC defektów molekularnych, prowadzących do zaburzeń ...
Kuczyńska, Martyna, Andrzejewska, Dominika, Grochowska, Wiktoria, Grygier, Joanna, Lewandowski, Krzysztof; Katedra i Klinika Hematologii i Transplantacji Szpiku, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Poland, Gulaczyk, Hanna, Łączak, Michał   +6 more
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