Results 71 to 80 of about 509,621 (191)
JAKs, STATs and Src kinases in hematopoiesis [PDF]
Oncogene, 2002 Hematopoiesis is the cumulative result of intricately regulated signal transduction cascades that are mediated by cytokines and their cognate receptors. Proper culmination of these diverse signaling pathways forms the basis for an orderly generation of different cell types and aberrations in these pathways is an underlying cause for diseases such as ...
Sushil G, Rane, E Premkumar, Reddy
openaire +2 more sources
G3: Genes, Genomes, Genetics, 2019 The Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) and epidermal growth factor receptor (EGFR) signaling pathways are conserved regulators of tissue patterning, morphogenesis, and other cell biological processes.
Julia Wittes, Trudi Schüpbach
doaj +1 more source
, 2022 reservedLa via JAK/STAT è un meccanismo di segnalazione evolutivamente conservato ed è attivato da diverse citochine, interferoni, fattori di crescita e molecole correlate. Questa via rappresenta uno straordinario meccanismo dove fattori extracellulari
LA TORRE, FEDERICO
core
The roles of the Drosophila JAK/STAT pathway [PDF]
Oncogene, 2000 The JAK/STAT signal transduction pathway has been conserved throughout evolution such that true structural and functional homologues of components originally identified in vertebrate systems are also present in the model genetic system Drosophila melanogaster.
M P, Zeidler, E A, Bach, N, Perrimon
openaire +2 more sources
Investigating the role of the JAK/STAT and MAPK pathways in ischaemia/reperfusion injury and inflammation [PDF]
, 2009 The signal transducer and activator of transcription (STAT) proteins are a family of transcription factors which transduce extracellular signals from cytokines, growth factors and G-proteins to the nucleus.
Barry, S.P.
core
JAK/STAT-dependent gene regulation by cytokines
, 2005 The Janus kinase-signal transducer and activator of transcription (Jak-STAT) pathway is essential for the signal transduction of many cytokines. Dysregulation of Jak-STAT signaling is associated with various human diseases.
Duschl, A. +2 more
core +1 more source
Revisiting Janus kinases as molecular drug targets for rheumatic diseases
Frontiers in MedicineJanus kinase (JAK) family members, as upstream regulators, phosphorylate not only themselves but also cytokine receptors and signal transducer and activator of transcription (STAT) proteins in the JAK-STAT signaling pathway.
Sunghark Kwon, Sunghark Kwon
doaj +1 more source
Wheezing and itching: The requirement for STAT proteins in allergic inflammation
, 2012 The development of allergic inflammation requires the orchestration of gene expression from the inflamed tissue and from the infiltrating immune cells.
Bruns, Heather A. +2 more
core +1 more source
JAK/STAT in leukemia: a clinical update
Molecular CancerOver the past three decades, considerable efforts have been expended on understanding the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway in leukemia, following the identification of the JAK2V617F mutation in ...
Dong Liang +7 more
doaj +1 more source
Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy
Cells, 2020 Cancer is a prevalent cause of mortality around the world. Aberrated activation of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway promotes tumorigenesis.
Sankhadip Bose +6 more
doaj +1 more source