Results 51 to 60 of about 509,621 (191)

Mutual repression between JNK/AP-1 and JAK/STAT stratifies senescent and proliferative cell behaviors during tissue regeneration.

PLoS Biology, 2023
Epithelial repair relies on the activation of stress signaling pathways to coordinate tissue repair. Their deregulation is implicated in chronic wound and cancer pathologies. Using TNF-α/Eiger-mediated inflammatory damage to Drosophila imaginal discs, we
Janhvi Jaiswal, Janine Egert, Raphael Engesser, Andrea Armengol Peyrotón, Liyne Nogay, Vanessa Weichselberger, Carlo Crucianelli, Isabelle Grass, Clemens Kreutz, Jens Timmer, Anne-Kathrin Classen   +10 more
doaj   +1 more source

Inhibidores de JAK: usos en dermatología. Parte 1: generalidades, aplicaciones en vitíligo y en alopecia areata

Actas Dermo-Sifiliográficas, 2021
Resumen: La vía de señalización de citocinas Janus cinasa/transductor de señal y activador de transcripción (JAK/STAT) es un área de interés emergente en dermatología, con evidencia creciente del papel clave en la patogénesis de las enfermedades ...
C. Garcia-Melendo, X. Cubiró, L. Puig
doaj   +1 more source

Expressionsanalyse ausgewählter Gene des JAK-STAT-Signalweges in Trophoblastzelllinien nach Stimulation mit GM-CSF, LIF und Oncostatin M [PDF]

, 2016
Phoblastzellen sind embryonale Plazentazellen, die invasiv in mütterliches Gewebe vordringen. Aufgrund dieser Eigenschaft werden sie oft mit Tumorzellen verglichen.
Beckus, Juliane
core   +1 more source

Integrating Immunologic Signaling Networks: The JAK/STAT Pathway in Colitis and Colitis-Associated Cancer

Vaccines, 2016
Cytokines are believed to be crucial mediators of chronic intestinal inflammation in inflammatory bowel diseases (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC).
Sebastian Zundler, Markus F. Neurath
doaj   +1 more source

JAK–STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review

Frontiers in Immunology, 2022
Atopic dermatitis (AD) is a chronic, inflammatory, pruritic form of dermatosis with heterogeneous manifestations that can substantially affect patients' quality of life. AD has a complex pathogenesis, making treatment challenging for dermatologists.
I-Hsin Huang, I-Hsin Huang, I-Hsin Huang, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Po-Chien Wu, Po-Chien Wu, Po-Chien Wu, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen   +27 more
doaj   +1 more source

F8 causes hypophosphorylation in JAK/STAT pathway.

, 2023
Human Phosphorylation Kinase Array C55 was conducted on the CCRF-CEM cell line and treated with 2X CC50 (5.78 μM). This assay was used to determine the phosphorylation status of MAPK and JAK-STAT membranes to gauge phosphorylation.
Armando Varela-Ramirez (456144), Denisse A. Gutierrez (5931755), Risa Mia Swain (17691698), Renato J. Aguilera (456143), Anahi Sanchez (15292082)   +4 more
core   +1 more source

microRNA-34 mediates a negative feedback loop in the JAK-STAT pathway to attenuate immune overactivation in an invertebrate

Cell Communication and Signaling
The JAK-STAT pathway is an essential signaling mechanism that initiates immune responses against pathogen infections. The intrinsic homeostatic regulation of JAK-STAT signaling is critical for maintaining immune homeostasis.
Hongliang Zuo, Alian Liao, Sihui Shen, Youxi Wang, Xiya Yang, Shaoping Weng, Jianguo He, Xiaopeng Xu   +7 more
doaj   +1 more source

The potential roles of JAK/STAT signaling in the progression of osteoarthritis

Frontiers in Endocrinology, 2022
Osteoarthritis (OA) is an age-related chronic progressive degenerative disease that induces persistent pain and disabilities. The development of OA is a complex process, and the risk factors are various, including aging, genetics, trauma and altered ...
Qingluo Zhou, Qun Ren, Linhui Jiao, Jishang Huang, Jun Yi, Jincai Chen, Jinliang Lai, Guanglin Ji, Tiansheng Zheng   +8 more
doaj   +1 more source

JAKs, Stats, and CK2? [PDF]

Blood, 2011
Activating mutations in JAK2, a tyrosine kinase that serves as a critical signaling protein for multiple cytokines, are associated with BCR-ABL1 –negative myeloproliferative neoplasms. In this issue of Blood , Zheng and colleagues report that the constitutively activated kinase CK2 binds to ...
Christin, Carter-Su, Lawrence S, Argetsinger   +1 more
openaire   +2 more sources

Systematic Review: JAK-STAT Regulation and Its Impact on Inflammation Response in ARDS from COVID-19

Immuno
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has had a global impact and resulted in millions of deaths worldwide. The course of the Janus kinase signaling transducers and activators (JAK-STAT) pathway is an important molecular ...
Irasema Rodriguez, Kate J. F. Carnevale
doaj   +1 more source